The following are health and medical definitions of terms that appear in the abciximab - injection, Reopro article.
Allergic reaction: The hypersensitive response of the immune system of an allergic individual to a substance.
Aneurysm: A localized widening (dilatation) of an artery, a vein, or the heart. At the point of an aneurysm, there is typically a bulge. The wall of the blood vessel or organ is weakened and may rupture.
Angioplasty: Procedure with a balloon-tipped catheter to enlarge a narrowing in a coronary artery. Also called Percutaneous Transluminal Coronary Angioplasty (PTCA).
Aspirin: Once the Bayer trademark for acetylsalicylic acid, now the common name for this anti-inflammatory pain reliever.
Balloon angioplasty: Coronary angioplasty is accomplished using a balloon-tipped catheter inserted through an artery in the groin or arm to enlarge a narrowing in a coronary artery. Coronary artery disease occurs when cholesterol plaque builds up (atherosclerosis) in the walls of the arteries to the heart. Angioplasty is successful in opening coronary arteries in 90% of patients. 40% of patients with successful coronary angioplasty will develop recurrent narrowing at the site of balloon inflation.
Bladder: A hollow organ in the lower abdomen that stores urine. The kidneys filter waste from the blood and produce urine, which enters the bladder through two tubes, called ureters. Urine leaves the bladder through another tube, the urethra. In women, the urethra is a short tube that opens just in front of the vagina. In men, it is longer, passing through the prostate gland and then the penis. Also known as urinary bladder and vesical.
Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".
Bowel: The small and large intestine.
Brain: The portion of the central nervous system that is located within the skull. It functions as a primary receiver, organizer, and distributor of information for the body. It has a right half and a left half, each of which is called a hemisphere.
Brain tumor: A benign or malignant growth in the brain. Primary brain tumors initially form in brain tissue. Secondary brain tumors are cancers that have spread (metastasized) to the brain tissue from tissue elsewhere in the body. Brain tumors can occur in people of any age.
Breast milk: Milk from the breast. Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system. Human milk also contains immunologic agents and other compounds that act against viruses, bacteria, and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction and then exhaled due to muscle relaxation.
Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart, and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum. Also known as thorax.
Chest pain: Pain in the chest that can be a result of many things, including angina, heart attack (coronary occlusion), and other important diseases. Chest pain is a warning to seek medical attention, so one should try not to ignore chest pain and 'work through it.'
Coughing up blood: see hemoptysis.
Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
Drain: A device for removing fluid from a cavity or wound. A drain is typically a tube or wick. As a verb, to allow fluid to be released from a confined area.
FDA: Food and Drug Administration.
Flush: (1) A redness of the skin, typically over the cheeks or neck. A flush is usually temporary and brought on by excitement, exercise, fever, or embarrassment. Flushing is an involuntary (uncontrollable) response of the nervous system leading to widening of the capillaries of the involved skin. Also referred to as a blush (or, as a verb, to blush). Flushing may also be caused by medications or other substances that cause widening of the capillaries, such as niacin. (2) Flush also means to wash out a wound or body area.
Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.
Groin: The area where the thigh meets the hip.
Heart: The muscle that pumps blood received from veins into arteries throughout the body. The heart is positioned in the chest behind the sternum (breastbone); in front of the trachea, esophagus, and aorta; and above the diaphragm. A normal heart is about the size of a closed fist and weighs about 298 grams or 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest, with the balance in the right side of the chest. The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an anatomically separate left atrium and ventricle. The blood flows from the systemic veins into the right atrium, thence to the right ventricle, from which it is pumped to the lungs and then returned into the left atrium, thence to the left ventricle, from which it is driven into the systemic arteries. The heart is thus functionally composed of two hearts: the right heart and the left heart. The right heart consists of the right atrium, which receives deoxygenated blood from the body, and the right ventricle, which pumps the deoxygenated blood to the lungs under low pressure; and the left heart, which consists of the left atrium, which receives oxygenated blood from the lung, and the left ventricle, which pumps the oxygenated blood out to the body under high pressure.
Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
Heparin: An anticoagulant (anti-clotting) medication. Heparin is useful in preventing thromboembolic complications (clots that travel from their site of origin through the blood stream to clog up another vessel). Heparin is also used in the early treatment of blood clots in the lungs (pulmonary embolisms).
Inflammation: A localized reaction that produces redness, warmth, swelling, and pain as a result of infection, irritation, or injury. Inflammation can be external or internal.
Inflammatory bowel disease: A group of chronic intestinal diseases characterized by inflammation of the bowel -- the large or small intestine. The most common types of inflammatory bowel disease (IBD) are ulcerative colitis and Crohn disease.
Laboratory: A place for doing tests and research procedures, and for preparing chemicals and some medications. Also known as lab.
Leg: In popular usage, the part of the body from the top of the thigh down to the foot, and in medical terminology, the portion of the lower extremity that runs from the knee to the ankle. The leg (in the medical sense) has two bones'the tibia (shinbone) and the fibula'both of which are known as long bones. The larger of the two is the tibia. The fibula runs alongside the tibia.
Limb: An arm or a leg.
Liver: The largest solid organ in the body, situated in the upper part of the abdomen on the right side. The liver has a multitude of important and complex functions, including to manufacture proteins, including albumin (to help maintain the volume of blood) and blood clotting factors; to synthesize, store, and process fats, including fatty acids (used for energy) and cholesterol; to metabolize and store carbohydrates (used as the source for the sugar in blood); to form and secrete bile that contains bile acids to aid in the intestinal absorption of fats and the fat-soluble vitamins A, D, E, and K; to eliminate, by metabolizing or secreting, the potentially harmful biochemical products produced by the body, such as bilirubin, from the breakdown of old red blood cells and ammonia from the breakdown of proteins; and to detoxify, by metabolizing and/or secreting, drugs, alcohol, and environmental toxins.
Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood.
Malformation: A structural defect in the body due to abnormal embryonic or fetal development. There are many types of malformations. For example, cleft lip and cleft palate. See also Congenital malformation.
Medical history: 1. In clinical medicine, the patient's past and present which may contain relevant information bearing on their health past, present, and future. The medical history, being an account of all medical events and problems a person has experienced is an important tool in the management of the patient.
Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.
Nosebleed: Bleeding from the blood vessels of the nose. The nose is rich in blood vessels and is situated in a vulnerable position on the face. As a result, any trauma to the face can cause bleeding, which may be profuse. Nosebleeds can also occur spontaneously when the nasal membranes dry out, crust, and crack, as is common in dry climates or during winter months, when the air is dry and warm from household heaters. People have increased susceptibility to nosebleeds if they are taking medications that prevent normal blood clotting, such as warfarin (brand name: Coumadin), aspirin, or any anti-inflammatory medication. Other predisposing factors include infection, trauma, allergic and nonallergic rhinitis, hypertension, alcohol abuse, and inherited bleeding problems. Also known as epistaxis.
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
Peptic ulcer: An ulcer in the lining of the stomach, duodenum, or esophagus. Peptic ulcers affect millions of people in the US yearly. Ulcer formation is related to Helicobacter pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Peptic ulcer pain may not correlate with the presence or severity of ulceration. Complications of peptic ulcers include bleeding, perforation, and blockage of the stomach (gastric obstruction). Diagnosis is made via barium X-ray or endoscopy. Treatment involves use of antibiotics to eradicate H. pylori, elimination of risk factors, and prevention of complications.
Percutaneous: Through the skin. For example, a percutaneous biopsy is a biopsy that is obtained by putting a needle through the skin in order to obtain tissue within the body for examination.
Pharmacist: A professional who fills prescriptions and, in the case of a compounding pharmacist, makes them. Pharmacists are very familiar with medication ingredients, interactions, and cautions.
Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.
Platelet count: The calculated number of platelets in a volume of blood, usually expressed as platelets per cubic millimeter (cmm) of whole blood. Platelets are the smallest cell-like structures in the blood and are important for blood clotting and plugging damaged blood vessels. Platelet counts are usually done by laboratory machines that also count other blood elements such as the white and red cells. They can also be counted by use of a microscope. Normal platelet counts are in the range of 150,000 to 400,000 per microliter (or 150 - 400 x 109 per liter). These values many vary slightly between different laboratories.
Poison: Any substance that can cause severe organ damage or death if ingested, breathed in, or absorbed through the skin. Many substances that normally cause no problems, including water and most vitamins, can be poisonous if taken in excessive quantity. Poison treatment depends on the 'substance.
Poison control center: A special information center set up to inform people about how to respond to potential poisoning. These centers maintain databases of poisons and appropriate emergency treatment. Local poison control centers should be listed with other community-service numbers in the front of the telephone book, and they can also be reached immediately through any telephone operator.
Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.
Proteins: Large molecules composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
Rash: Breaking out (eruption) of the skin. A rash can be caused by an underlying medical condition, hormonal cycles, allergies, or contact with irritating substances. Treatment depends on the underlying cause of the rash. Medically, a rash is referred to as an exanthem.
Stent: A tube designed to be inserted into a vessel or passageway to keep it open. Stents are inserted into narrowed coronary arteries to help keep them open after balloon angioplasty. The stent then allows the normal flow of blood and oxygen to the heart. Stents placed in narrowed carotid arteries (the vessels in the front of the neck that supply blood to the brain) appear useful in treating patients at elevated risk for stroke. Stents are also used in other structures such as the esophagus to treat a constriction, the ureters to maintain the drainage of urine from the kidneys, and the bile duct to keep it open.
Stool: The solid matter that is discharged in a bowel movement.
Stroke: The sudden death of brain cells due to lack of oxygen, caused by blockage of blood flow or rupture of an artery to the brain. Sudden loss of speech, weakness, or paralysis of one side of the body can be symptoms. A suspected stroke can be confirmed by scanning the brain with special X-ray tests, such as CAT scans. The death rate and level of disability resulting from strokes can be dramatically reduced by immediate and appropriate medical care. Prevention involves minimizing risk factors, such as controlling high blood pressure and diabetes. Abbreviated CVA. Also known as cerebrovascular accident.
Thrombocytopenia: : A low platelet count. Platelets are irregular, disc-shaped element in the blood that assists in blood clotting. thrombocytopenia can arise due to decreased production of platelets in the bone marrow or increased breakdown of platelets in the bloodstream, spleen, or liver. Thrombocytopenia is characterized by easy bruising and increased bleeding.
Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands).
Ulcer: A lesion that is eroding away the skin or mucous membrane. Ulcers can have various causes, depending on their location. Ulcers on the skin are usually due to irritation, as in the case of bedsores, and may become inflamed and/or infected as they grow. Ulcers in the gastrointestinal tract were once attributed to stress, but most are now believed to be due to infection with the bacterium Helicobacter pylori. GI ulcers, however, are often made worse by stress, smoking, and other noninfectious factors.
Urine: Liquid waste produced by the kidneys. Urine is a clear, transparent fluid that normally has an amber color. The average amount of urine excreted in 24 hours is between 5 to 8 cups or 40 and 60 ounces. Chemically, urine is mainly a watery solution of salt and substances called urea and uric acid. Normally, it contains about 960 parts water to 40 parts solid matter. Abnormally, it may contain sugar (in diabetes), albumin (a protein, as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.
Vasculitis: A general term for a group of uncommon diseases that feature inflammation of the blood vessels. Each of the vasculitis diseases is defined by characteristic distributions of blood vessel involvement, patterns of organ involvement, and laboratory test abnormalities. The actual causes of these vasculitis diseases are usually not known, but immune system abnormality is a common feature. Examples of vasculitis include Kawasaki disease, Behcet's disease, polyarteritis nodosa, Wegener's granulomatosis, Takayasu's arteritis, Churg-Strauss syndrome, giant cell arteritis (temporal arteritis), and Henoch-Schonlein purpura. Vasculitis can also accompany infections, such as hepatitis B; exposure to chemicals, such as amphetamines and cocaine; cancers, such as lymphomas and multiple myeloma; and rheumatic diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Laboratory testing in a patient with active vasculitis generally indicates inflammation in the body, and depending on the degree of organ involvement, a variety of organ function tests can be abnormal. The ultimate diagnosis for vasculitis is typically established after a biopsy of involved tissue demonstrates the pattern of blood vessel inflammation. Treatment depends on the type and severity of the illness and the organs involved. Treatments are generally directed toward stopping the inflammation and suppressing the immune system. Typically, cortisone-related medications, such as prednisone, are used, as are other immune-
Vein: A blood vessel that carries blood that is low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxy-hemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system, which returns blood to the heart. In contrast, an artery is a vessel that carries blood that is high in oxygen away from the heart to the body.
Vessel: A tube in the body that carries fluids. Examples of vessels are blood vessels and lymph vessels.
Vomit: Matter from the stomach that has come up into and may be ejected beyond the mouth, due to the act of vomiting.
Warfarin: An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks.
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