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Medications and Drugs

Brand Names: Acuflex, Ali-Flex, Alpain, BeFlex, BP Poly-650, Dologen, Dologesic, Dologesic DF, Flextra-DS, Hyflex-650, Hyflex-DS, Relagesic, RhinoFlex, RhinoFlex 650, Staflex, Vistra, Zgesic

Generic Name: acetaminophen and phenyltoloxamine (Pronunciation: a seet a MIN oh fen and FEN il toe LOX a meen)

What is acetaminophen and phenyltoloxamine (Acuflex, Ali-Flex, Alpain, BeFlex, BP Poly-650, Dologen, Dologesic, Dologesic DF, Flextra-DS, Hyflex-650, Hyflex-DS, Relagesic, RhinoFlex, RhinoFlex 650, Staflex, Vistra, Zgesic)?

Acetaminophen is a pain reliever and a fever reducer.

Phenyltoloxamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Acetaminophen and phenyltoloxamine is used to treat runny nose, sneezing, and pain or fever caused by the common cold, flu, or seasonal allergies.

Acetaminophen and phenyltoloxamine may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen and phenyltoloxamine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeat;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe dizziness, anxiety, restless feeling, nervousness;
  • urinating less than usual or not at all;
  • nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay colored stools, jaundice (yellowing of the skin or eyes); or
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms.

Less serious side effects may include:

  • dizziness, drowsiness;
  • blurred vision;
  • dry mouth, nose, or throat;
  • mild stomach pain, constipation; or
  • problems with memory or concentration.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen and phenyltoloxamine?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Do not use cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver or kidney disease, diabetes, glaucoma, urination problems, an enlarged prostate, heart disease, high blood pressure, a stomach ulcer, or an overactive thyroid.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Identifier Tool

Need help identifying pills and medications?
Use the pill finder tool on RxList.



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