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Acid Reflux Disease (GERD) (cont.)

Acid Reflux (GERD) Medications

These drugs use different mechanisms to reduce reflux.

Proton pump inhibitors (PPIs)

Coating agents

Sucralfate (Carafate) coats mucous membranes and sores to provide an additional protective barrier against stomach acid.

Promotility agents

  • Promotility agents include metoclopramide (Reglan, Clopra, Maxolon) and bethanechol (Duvoid, Urabeth, Urecholine).
  • They help tighten the lower esophageal sphincter and promote faster emptying of the stomach.
  • Health care professionals often are reluctant to prescribe these medications because they have fairly significant side effects.
  • Promotility agents also do not work as well as PPIs for most people.
  • One of these agents, cisapride (Propulsid), has been removed from the US market because of safety concerns related to lethal drug interactions.
Medically Reviewed by a Doctor on 2/13/2013
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Patient Comments & Reviews

The eMedicineHealth doctors ask about Acid Reflux (GERD):

GERD - Proton Pump Inhibitors

Heartburn symptoms caused by GERD are usually relieved by drugs called proton pump inhibitors (PPIs), such as Prilosec, Prevacid, Aciphex, Protonix, Nexium, Zegerid; however, sometimes they do not work well. Can you please describe your GERD symptoms that did not improve on PPIs? Did you find other treatments effective?

GERD - Symptoms and Signs

What were your GERD symptoms and signs?





Read What Your Physician is Reading on Medscape

Gastroesophageal Reflux Disease »

Gastroesophageal reflux is a normal physiological phenomenon experienced intermittently by most people, particularly after a meal.

Read More on Medscape Reference »


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