Hasnain M Khandwala, MD, FRCPC
Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS
Francisco Talavera, PharmD, PhD
George T Griffing, MD
IN THIS ARTICLE
Some adenomas are aggressive, growing quickly. In these cases, the signs and symptoms of acromegaly tend to develop fairly quickly. Others grow more slowly, causing very gradual onset of symptoms. In these cases, symptoms might appear several years before the disease is diagnosed.
Symptoms can be divided into 2 groups: those that are effects of the tumor pressing on surrounding tissues and those caused by excess growth hormone and IGF-1 in the blood.
Symptoms due to pressure on surrounding tissues depend on the size of the tumor.
Symptoms due to excess growth hormone or IGF-I vary widely.
Acromegaly that affects the heart or blood pressure or causes diabetes may have another set of symptoms. These do not occur in everyone with acromegaly.
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