Hasnain M Khandwala, MD, FRCPC
Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS
Francisco Talavera, PharmD, PhD
George T Griffing, MD
IN THIS ARTICLE
One goal of drug therapy in acromegaly is to normalize levels of growth hormone and IGF-1 in the bloodstream. Another is to shrink the tumor.
Growth hormone receptor blockers are the newest category of drugs used for acromegaly. These drugs work by blocking the site on the cell where growth hormone "docks." If the growth hormone can't dock, it can't cause abnormal growth.
Somatostatin analogues act like the hormone somatostatin. They work by stopping secretion of growth hormone, just as somatostatin does.
Dopamine agonists promote the activity of dopamine, a chemical in the brain. These drugs work by stopping secretion of growth hormone by some pituitary tumors.
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