Many of the symptoms result from the enlargement of tissues caused by excess growth hormone and IGF-1 in the blood.

• Arthritis, back pain, and curvature of the spine (kyphosis) - Due to enlargement of bones and cartilage in joints
  
  
• Swelling of the face, lips, and tongue
  
  
• Breathing problems during sleep - Due to narrowing of the airway resulting from swelling
  
  
• Tiredness during the day - Due to poor sleep
  
  
• Thickening of the skin
  
  
• Oily skin or acne
  
  
• Increased sweating
  
  
• Tingling or numbness in the fingers or toes - Due to entrapment of nerves by enlarging muscles  
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• Change in bite or chewing, or spreading out of teeth - Due to enlargement of jaw and other facial bones
  
  
• Large numbers of skin tags
  
  
• Vision loss, partial or complete
  
  
• Headaches

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