Addiction (cont.)

OTC and Prescription Drug Abuse Slideshow Pictures

Health Risks of Alcohol Abuse Slideshow Pictures

Medical Author:

Maureen C Nash, MD, MS

Coauthor:

Jessica B Johnson

Medical Editor:

Melissa Conrad Stöppler, MD, Chief Medical Editor

Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

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The essence of addiction is drug craving, seeking, and use, in the face of negative health or social consequences. This is the basis for how the Institute of Medicine, the American Psychiatric Association, and the American Medical Association define addiction. Some common characteristics of addictions include the following:

The substance or activity that triggers addiction must initially cause feelings of pleasure and changes in emotion or mood.

The body develops a physical tolerance to the substance or activity, so people with addictions must take larger and larger amounts of a substance to feel the same effects.

Removal of the drug or activity causes painful withdrawal symptoms.

More than physical tolerance, an addiction involves physical and psychological dependence separate from the need to avoid the pain of withdrawal.

Addiction always causes physiological, chemical, and anatomical changes in the brain along with behavioral changes.

Addiction develops after an initial exposure to the addicting substance or activity. That initial exposure must occur for addiction to develop, but the exposure does not always lead to addiction.