Adenosine

Are there any interactions with medications?

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Dipyridamole (Persantine)
Interaction Rating: Major Do not take this combination.

The body breaks down adenosine to get rid of it. Dipyridamole (Persantine) can decrease the break down of adenosine. Decreasing the breakdown of adenosine can cause heart problems. Do not take adenosine if you are taking dipyridamole (Persantine).

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Carbamazepine (Tegretol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Adenosine can slow down the heartbeat. Taking carbamazepine (Tegretol) with adenosine might cause the heart to beat too slowly. Do not take adenosine if you are taking carbamazepine (Tegretol).

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Medications for gout (Antigout drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Gout is caused by a build-up of uric acid crystals in the joints. Adenosine can increase uric acid in the body and might reduce the effectiveness of medications for gout.

Some medications for gout include allopurinol (Zyloprim), colchicine, probenecid (Benemid), and others.

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Methylxanthines
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Methylxanthines might block the effects of adenosine. Adenosine is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop drinking black tea or other caffeine containing products at least 24 hours before a cardiac stress test.

Methylxanthines include aminophylline, caffeine, and theophylline.

Dosing considerations for Adenosine.

The following doses have been studied in scientific research:

INTRAVENOUS:

• For certain types of irregular heartbeat and also for weight loss in people with advanced cancer: Healthcare providers give adenosine as a shot (by injection).

INTRAMUSCULAR:

• For treating wounds in the legs due to poor blood circulation: Healthcare providers give adenosine intramuscularly (by injection into the muscle).