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Medications and Drugs

Brand Names: Amevive

Generic Name: alefacept (Pronunciation: ah LEH fa cept)

What is alefacept (Amevive)?

Alefacept is a protein that reduces specific actions of the immune system that are involved in causing psoriasis.

Alefacept is used for the treatment of moderate to severe chronic plaque psoriasis in people who are candidates for systemic therapy or phototherapy.

Alefacept may also be used for purposes other than those listed here.

What are the possible side effects of alefacept (Amevive)?

Alefacept reduces levels of certain white blood cells in the body. If the level of these white blood cells falls too low, treatment with alefacept may need to be withheld temporarily or discontinued. Your doctor will monitor your white blood cell levels during treatment.

Alefacept may increase the risk of developing cancer. Do not use alefacept without first talking to your doctor if you have cancer or a history of cancer.

Alefacept reduces certain actions of the immune system and may increase the risk of developing a new infection or reactivating a chronic infection that has been latent (inactive). Contact your doctor immediately if you develop symptoms of an infection such as fever or chills, sore throat, coughing, or burning with urination.

Stop using alefacept and seek emergency medical attention if you develop symptoms of an allergic reaction such as difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives.

Other less serious side effects may be more likely to occur. Continue to use alefacept and talk to your doctor if you experience

  • sore throat or cough;
  • dizziness;
  • headache
  • nausea;
  • itching;
  • muscle aches;
  • chills; or
  • pain, discomfort, or inflammation at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about alefacept (Amevive)?

Patients with HIV should not take alefacept. Talk to your doctor before taking alefacept if you are HIV positive.

Alefacept reduces levels of certain white blood cells in the body. If the level of these white blood cells falls too low, treatment with alefacept may need to be withheld temporarily or discontinued. Your doctor will monitor your white blood cell levels during treatment.

Alefacept may increase the risk of developing cancer. Do not use alefacept without first talking to your doctor if you have cancer or a history of cancer.

Alefacept reduces certain actions of the immune system and may increase the risk of developing a new infection or reactivating a chronic infection that has been latent (inactive). Contact your doctor immediately if you develop symptoms of an infection such as fever or chills, sore throat, coughing, or burning with urination.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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