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Medications and Drugs

Brand Names: Etrafon Forte, Triavil

Generic Name: amitriptyline and perphenazine (Pronunciation: a mee TRIP ti leen and per FEN a zeen)

What is amitriptyline and perphenazine (Etrafon Forte, Triavil)?

Amitriptyline is in a group of drugs called tricyclic antidepressants. Amitriptyline affects chemicals in the brain that may become unbalanced.

Perphenazine is in a group of drugs called phenothiazines (feen-oh-THYE-a-zeens). Perphenazine affects chemicals in the brain that may become unbalanced and cause anxiety.

The combination of amitriptyline and perphenazine is used to treat depression, anxiety, and agitation.

Amitriptyline and perphenazine may also be used for purposes not listed in this medication guide.

Amitriptyline-Perphenazine 10 mg-2 mg-MYL

round, white, imprinted with 330, MYLAN

Amitriptyline-Perphenazine 10-4mg-MYL

round, blue, imprinted with 727, MYLAN

Amitriptyline-Perphenazine 25 mg-2 mg-MYL

round, purple, imprinted with 442, MYLAN

Amitriptyline-Perphenazine 25 mg-4 mg-MYL

round, orange, imprinted with 574, MYLAN

Amitriptyline-Perphenazine 50-4mg-MYL

round, purple, imprinted with 73, MYLAN

What are the possible side effects of amitriptyline and perphenazine (Etrafon Forte, Triavil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • tremor (uncontrolled shaking);
  • fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
  • feeling like you might pass out;
  • seizures (convulsions);
  • slow heart rate, chest pain or heavy feeling;
  • easy bruising or bleeding;
  • jaundice (yellowing of your skin or eyes);
  • painful or difficult urination; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • feeling dizzy, drowsy, or tired;
  • strange dreams or nightmares;
  • sleep problems (insomnia);
  • dry mouth, loss of appetite;
  • nausea, vomiting, diarrhea, constipation;
  • blurred vision;
  • breast changes; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amitriptyline and perphenazine (Etrafon Forte, Triavil)?

You should not take this medication if you are allergic to amitriptyline (Elavil, Vanatrip, Limbitrol) or perphenazine (Trilafon), or if you have liver damage, a weak immune system, a blood cell disorder (such as anemia), or if you have recently had a heart attack.

Do not use amitriptyline and perphenazine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not drink alcohol. Amitriptyline and perphenazine can increase the effects of alcohol, which could be dangerous.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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