Anatomy of the Central Nervous System

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Medical Author:

Fernando Dangond, MD

Medical Editor:

Melissa Conrad Stöppler, MD, Chief Medical Editor

Melissa Conrad Stöppler, MD, Chief Medical Editor

Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

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• Central Nervous System Overview
  • The Brain
  • The Spinal Cord
• Peripheral Nervous System
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• Synonyms and Keywords
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Central Nervous System Overview

The central nervous system consists of the brain and spinal cord (see Multimedia File 1).

• The brain plays a central role in the control of most bodily functions, including awareness, movements, sensations, thoughts, speech, and memory. Some reflex movements can occur via spinal cord pathways without the participation of brain structures. 



• The spinal cord is connected to a section of the brain called the brainstem and runs through the spinal canal. Cranial nerves exit the brainstem. Nerve roots exit the spinal cord to both sides of the body. The spinal cord carries signals (messages) back and forth between the brain and the peripheral nerves.

Cerebrospinal fluid surrounds the brain and the spinal cord and also circulates within the cavities (called ventricles) of the central nervous system. The leptomeninges surround the brain and the spinal cord. The cerebrospinal fluid circulates between 2 meningeal layers called the pia matter and the arachnoid (or pia-arachnoid membranes). The outer, thicker layer serves the role of a protective shield and is called the dura matter.

The basic unit of the central nervous system is the neuron (nerve cell). Billions of neurons allow the different parts of the body to communicate with each other via the brain and the spinal cord. A fatty material called myelin coats nerve cells to insulate them and to allow nerves to communicate quickly.