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Anatomy of the Endocrine System

Endocrine System Introduction

The endocrine system is made up of glands that produce and secrete hormones. These hormones regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function. The hormones are released into the bloodstream and may affect one or several organs throughout the body.

Hormones are chemical messengers created by the body. They transfer information from one set of cells to another to coordinate the functions of different parts of the body.

The major glands of the endocrine system are the hypothalamus, pituitary, thyroid, parathyroids, adrenals, pineal body, and the reproductive organs (ovaries and testes). The pancreas is also a part of this system; it has a role in hormone production as well as in digestion.

The endocrine system is regulated by feedback in much the same way that a thermostat regulates the temperature in a room. For the hormones that are regulated by the pituitary gland, a signal is sent from the hypothalamus to the pituitary gland in the form of a "releasing hormone," which stimulates the pituitary to secrete a "stimulating hormone" into the circulation. The stimulating hormone then signals the target gland to secrete its hormone. As the level of this hormone rises in the circulation, the hypothalamus and the pituitary gland shut down secretion of the releasing hormone and the stimulating hormone, which in turn slows the secretion by the target gland. This system results in stable blood concentrations of the hormones that are regulated by the pituitary gland.

Hormones Regulated by the Hypothalamic/Pituitary System

Hormone Pituitary Stimulating Hormone Hypothalamic Releasing Hormone
Thyroid hormones T4, T3 Thyroid-stimulating hormone (TSH) Thyrotropin-releasing hormone (TRH)
Cortisol Adrenocorticotropin hormone (ACTH) Corticotropin-releasing factor (CRF)
Estrogen or testosterone Follicle-stimulating hormone (FSH), luteinizing hormone (LH) Luteinizing hormone-releasing hormone (LHRH) or gonadotropin-releasing hormone (GnRH)
Insulinlike growth factor-I (IGF-I) Growth hormone Growth hormone-releasing hormone (GHRH)

Illustration of the Endocrine System
Illustration of the endocrine system.



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Anatomy of the Endocrine System

What is growth hormone deficiency?

Growth hormone deficiency is a disorder that involves the pituitary gland (a small gland located at the base of the brain). This gland produces growth hormone and other hormones (chemical messengers of the body). When it does not produce enough growth hormone, growth will be slower than normal. If other pituitary hormones are absent or present in inadequate amounts, the condition is called hypopituitarism.

Growth hormone deficiency can occur at any age. Growth hormone is necessary for normal growth and development in children. In adults, growth hormone is needed to maintain the proper amounts of body fat, muscle, and bone. In adults, low or absent growth hormone can also cause emotional symptoms, such as tiredness and lack of motivation.

What causes growth hormone deficiency?

Growth hormone deficiency is caused by low or absent secretion of growth hormone from the pituitary gland. This condition may be...

Read the Growth Hormone Deficiency FAQs article »



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