Medications

The goal of drug therapy is to control pain and decrease inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used medications. NSAIDs reduce pain and inflammation. No particular NSAID, such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn), has been shown to be clearly superior for treating AS. Sulfasalazine, corticosteroids, and other immunosuppressive agents are also used but are of limited benefit.

Recently, biologic agents have been found to be useful in treating AS. Antibodies to tumor necrosis factor, such as etanercept (Enbrel) and infliximab (Remicade), are now approved to treat AS. These target the disease process and may alter the disease process.

For more information, see Understanding Ankylosing Spondylitis Medications.