GENERIC NAME: ARSENIC TRIOXIDE - INJECTABLE (AR-sen-ik try-OX-ide)

BRAND NAME(S): Trisenox

Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert

WARNING: Arsenic trioxide is a potent medication that may cause serious, and in rare cases, fatal side effects. Only doctors familiar with treating cancer (oncologists) should give this drug. Infrequently, this medication may cause a serious syndrome called APL differentiation syndrome. Tell your doctor immediately if the following effects of this syndrome occur: unusual/unexplained fever, trouble breathing, and/or weight gain. Your doctor may also perform certain exams or tests (e.g., lung exam, x-rays) to determine if this syndrome has developed. Infrequently, this medication can also cause serious (sometimes fatal) heart problems (e.g., AV block, torsades de pointes-type arrhythmias). Tell your doctor if you have any medical history of heart problems (e.g., arrhythmia, heart failure), kidney problems, low levels of calcium, potassium, or magnesium in your blood; or if you take any medications that increase your risk for these heart problems (see DRUG INTERACTIONS section). Tell your doctor immediately if you develop any dizziness, fainting, or any fast or irregular heartbeat.

USES: Arsenic trioxide is used to treat a type of leukemia (acute promyelocytic leukemia-APL) with specific DNA characteristics (t(15;17) translocation) and who have not responded well to other types of cancer chemotherapy.

HOW TO USE: Follow all instructions for proper mixing and dilution with the correct IV fluids. If you have questions regarding the use of this medication, consult your pharmacist. Give this medication by vein (IV) over 1 to 2 hours mixed in a dextrose or saline solution (D5W or NS) once daily or as directed by your doctor. The dosage and length of treatment is based on your weight, medical condition, and response to therapy. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not mix arsenic trioxide with other medications. Do not save unused portions for later use. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.