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Medications for bedbug bites are usually not necessary. As noted above, over-the-counter antihistamine pills or creams (diphenhydramine) may be used for the itching. Corticosteroid creams (hydrocortisone) applied to the affected area may also be helpful for some individuals.
If a secondary bacterial skin infection develops, an antibiotic ointment or an oral antibiotic may be prescribed by your health-care provider.
Rarely, in cases of systemic allergic reactions, injections of epinephrine, antihistamines, and corticosteroids may be administered.
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