The following are health and medical definitions of terms that appear in the benazepril and hydrochlorothiazide, Lotensin HCT article.
Absorption: Uptake. For example, intestinal absorption is the uptake of food (or other substances) from the digestive tract.
Allergy: A misguided reaction to foreign substances by the immune system, the body system of defense against foreign invaders, particularly pathogens (the agents of infection). The allergic reaction is misguided in that these foreign substances are usually harmless. The substances that trigger allergy are called allergen. Examples include pollens, dust mite, molds, danders, and certain foods. People prone to allergies are said to be allergic or atopic.
Angiotensin: A family of peptides that constrict blood vessels. Narrowing the diameter of the blood vessels causes blood pressure to rise.
Angiotensin converting enzyme: Usually abbreviated ACE.
Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
Arthritis: Inflammation of a joint. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis. (see osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, pseudogout).
Aspirin: Once the Bayer trademark for acetylsalicylic acid, now the common name for this anti-inflammatory pain reliever.
Bilateral: Affecting both sides. For example, bilateral arthritis affects joints on both the left and right sides of the body.
Blood glucose: The main sugar that the body makes from the food in the diet. Glucose is carried through the bloodstream to provide energy to all cells in the body. Cells cannot use glucose without the help of insulin.
Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".
Breast milk: Milk from the breast. Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system. Human milk also contains immunologic agents and other compounds that act against viruses, bacteria, and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction and then exhaled due to muscle relaxation.
Cough: A rapid expulsion of air from the lungs, typically in order to clear the lung airways of fluids, mucus, or other material. Also known as tussis.
Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
Diuretic: Something that promotes the formation of urine by the kidney. All diuretics cause a person to 'lose water,' but they do so by diverse means, including inhibiting the kidney's ability to reabsorb sodium, thus enhancing the loss of sodium and consequently water in the urine (loop diuretic); enhancing the excretion of both sodium and chloride in the urine so that water is excreted with them (thiazide diuretic); or blocking the exchange of sodium for potassium, resulting in excretion of sodium and potassium but relatively little loss of potassium (potassium-sparing diuretic). Some diuretics work by yet other mechanisms, and some have other effects and uses, such as in treating hypertension. Also known as water pill. Substances in food and drinks, such as coffee, tea, and alcoholic beverages, may act as diuretics.
Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
Dysfunction: Difficult function or abnormal function.
Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist.
Eskalith: See: Lithium.
Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist.
FDA: Food and Drug Administration.
Fetus: An unborn offspring, from the embryo stage (the end of the eighth week after conception, when the major structures have formed) until birth.
Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines.
Gastrointestinal tract: The stomach and intestines. Abbreviated GI tract.
Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.
Glucose: The simple sugar that is the chief source of energy. Glucose is found in the blood and is the main sugar that the body manufactures. The body makes glucose from all three elements of food'protein, fats, and carbohydrates'but the largest amount of glucose derives from carbohydrates. Glucose serves as the major source of energy for living cells. However, cells cannot use glucose without the help of insulin. Also known as dextrose.
Heart: The muscle that pumps blood received from veins into arteries throughout the body. The heart is positioned in the chest behind the sternum (breastbone); in front of the trachea, esophagus, and aorta; and above the diaphragm. A normal heart is about the size of a closed fist and weighs about 298 grams or 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest, with the balance in the right side of the chest. The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an anatomically separate left atrium and ventricle. The blood flows from the systemic veins into the right atrium, thence to the right ventricle, from which it is pumped to the lungs and then returned into the left atrium, thence to the left ventricle, from which it is driven into the systemic arteries. The heart is thus functionally composed of two hearts: the right heart and the left heart. The right heart consists of the right atrium, which receives deoxygenated blood from the body, and the right ventricle, which pumps the deoxygenated blood to the lungs under low pressure; and the left heart, which consists of the left atrium, which receives oxygenated blood from the lung, and the left ventricle, which pumps the oxygenated blood out to the body under high pressure.
Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling (edema), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart.
High blood pressure: A repeatedly elevated blood pressure exceeding 140 over 90 mmHg. Chronic high blood pressure can stealthily cause blood vessel changes in the back of the eye (retina), abnormal thickening of the heart muscle, kidney failure, and brain damage. No specific cause for high blood pressure is found in 95 percent of patients. Treatment for high blood pressure involves dietary changes, regular aerobic exercise, and medication. There are many types of medications used to treat high blood pressure including diuretics, beta-blockers, blood vessel dilators, and others. Also known as hypertension.
Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
Hypotension: Any blood pressure that is below the normal expected for an individual in a given environment. Hypotension is the opposite of hypertension (abnormally high blood pressure).
Injury: Harm or hurt. To harm, hurt, or wound. The word injure may be in physical or emotional sense. From the Latin injuria meaning injury.
Jaundice: Yellow staining of the skin and sclerae (the whites of the eyes) by abnormally high blood levels of the bile pigment bilirubin. The yellowing extends to other tissues and body fluids. Jaundice was once called the "morbus regius" (the regal disease) in the belief that only the touch of a king could cure it.
Kidney: One of a pair of organs located in the right and left side of the abdomen. The kidneys remove waste products from the blood and produce urine. As blood flows through the kidneys, the kidneys filter waste products, chemicals, and unneeded water from the blood. Urine collects in the middle of each kidney, in an area called the renal pelvis. It then drains from the kidney through a long tube, the ureter, to the bladder, where it is stored until elimination. The kidneys also make substances that help control blood pressure and regulate the formation of red blood cells.
Lithium: A naturally occurring salt that, in purified form, is used to treat certain psychiatric disorders, especially bipolar disease The therapeutic level of lithium'the amount needed to treat bipolar disorders'is perilously close to the level that can cause toxicity, so monitoring of blood levels is required. Symptoms of lithium toxicity include diarrhea, vomiting, blurred vision, loss of coordination, and loss of motor control. Treatment of lithium toxicity involves immediately reducing or discontinuing lithium use under medical supervision.
Lithobid: See: Lithium.
Liver: The largest solid organ in the body, situated in the upper part of the abdomen on the right side. The liver has a multitude of important and complex functions, including to manufacture proteins, including albumin (to help maintain the volume of blood) and blood clotting factors; to synthesize, store, and process fats, including fatty acids (used for energy) and cholesterol; to metabolize and store carbohydrates (used as the source for the sugar in blood); to form and secrete bile that contains bile acids to aid in the intestinal absorption of fats and the fat-soluble vitamins A, D, E, and K; to eliminate, by metabolizing or secreting, the potentially harmful biochemical products produced by the body, such as bilirubin, from the breakdown of old red blood cells and ammonia from the breakdown of proteins; and to detoxify, by metabolizing and/or secreting, drugs, alcohol, and environmental toxins.
Low blood pressure: Any blood pressure that is below the normal expected for an individual in a given environment. Low blood pressure is also referred to as hypotension.
Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."
Naprelan: See: Naproxen.
Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.
Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.
Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
Pancreatitis: Inflammation of the pancreas. Of the many causes of pancreatitis, the most common are alcohol consumption and gallstones. Other causes include medications (azathioprine, estrogen, thiazides, metronidazole, valproic acid, and tetracycline), trauma, abdominal surgery, abnormalities of the pancreas and intestine, and infections such as mumps. Acute pancreatitis usually begins with pain in the upper abdomen that may last for a few days. The pain may be sudden and intense, or it may begin as a mild pain that is aggravated by eating and slowly grows worse. The abdomen may be very tender. Other symptoms may include nausea, vomiting, and fever. The patient often feels and looks very sick. Chronic pancreatitis usually follows many years of alcohol abuse and may cause pain; malabsorption of food, leading to weight loss; and diabetes, if the insulin-producing cells of the pancreas (islet cells) are damaged.
Potassium: The major positive ion (cation) found inside cells. The chemical notation for potassium is K+. The proper level of potassium is essential for normal cell function. An abnormal increase in potassium (hyperkalemia) or decrease in potassium (hypokalemia) can profoundly affect the nervous system and heart, and when extreme, can be fatal. The normal blood potassium level is 3.5'5.0 milliEquivalents/liter (mEq/L), or 3.5 international units.
Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.
Rash: Breaking out (eruption) of the skin. A rash can be caused by an underlying medical condition, hormonal cycles, allergies, or contact with irritating substances. Treatment depends on the underlying cause of the rash. Medically, a rash is referred to as an exanthem.
Reabsorption: Being absorbed again. For example, the kidney selectively reabsorbs substances it has already secreted into the renal tubules, such as glucose, protein, and sodium. These reabsorbed substances are returned to the blood.
Renal: Having to do with the kidney. For example, renal cancer is cancer of the kidneys.
Renal artery stenosis: Narrowing of the major artery to the kidney that can lead to seriously elevated blood pressure. Common causes of renal artery stenosis include atherosclerosis and thickening of the muscular wall (fibromuscular dysplasia) of the renal artery.
Rhabdomyolysis: A condition in which skeletal muscle is broken down, releasing muscle enzymes and electrolytes from inside the muscle cells. Risks of rhabdomyolysis include muscle breakdown and kidney failure because the cellular component myo-
Rheumatoid arthritis: An autoimmune disease characterized by chronic inflammation of joints. Rheumatoid disease can also involve inflammation of tissues in other areas of the body, such as the lungs, heart, and eyes. Because it can affect multiple organs of the body, rheumatoid arthritis is referred to as a systemic illness. Although rheumatoid arthritis is a chronic illness, patients may experience long periods without symptoms. Also known as rheumatoid disease.
Sodium: The major positive ion (cation) in the fluid surrounding cells in the body. The chemical notation for sodium is Na+. When sodium is combined with chloride, the resulting substance is a crystal called table salt. Excess dietary sodium is largely excreted in the urine, but too much salt in the diet tends to increase the blood pressure. Too much or too little sodium in the blood (called hypernatremia or hyponatremia respectively) can cause cells to malfunction, and extremes can be fatal. Normal blood sodium level is 135'145 milliEquivalents/liter (mEq/L) or 135'145 millimoles/liter (mmol/L) in international units.
Stenosis: A narrowing. For example, aortic stenosis is a narrowing of the aortic valve in the heart.
Stomach: The digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine. When food enters the stomach, muscles in the stomach wall create a rippling motion (peristalsis) that mixes and mashes the food. At the same time, juices made by glands in the lining of the stomach help digest the food. After about 3 hours, the food becomes a liquid and moves into the small intestine, where digestion continues.
Therapy: The treatment of disease. Therapy is synonymous with treatment.
Toxicity: The degree to which a substance (a toxin or poison) can harm humans or animals. Acute toxicity involves harmful effects in an organism through a single or short-term exposure. Subchronic toxicity is the ability of a toxic substance to cause effects for more than one year but less than the lifetime of the exposed organism. Chronic toxicity is the ability of a substance or mixture of substances to cause harmful effects over an extended period, usually upon repeated or continuous exposure, sometimes lasting for the entire life of the exposed organism.
Trimester: In obstetrics, one of the three divisions of three months each during pregnancy, in which different phases of fetal development take place. The first trimester is a time of basic cell differentiation. The second trimester is a period of rapid growth and maturation of body systems. A second-trimester fetus that is born prematurely may be viable, given the best hospital care possible. The third trimester marks the final stage of fetal growth, in which systems are completed, fat accumulates under the soon-to-be-born baby's skin, and the fetus at last moves into position for birth. This trimester ends with birth.
Urine: Liquid waste produced by the kidneys. Urine is a clear, transparent fluid that normally has an amber color. The average amount of urine excreted in 24 hours is between 5 to 8 cups or 40 and 60 ounces. Chemically, urine is mainly a watery solution of salt and substances called urea and uric acid. Normally, it contains about 960 parts water to 40 parts solid matter. Abnormally, it may contain sugar (in diabetes), albumin (a protein, as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.
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