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Blood Clot in the Legs (cont.)

Medications

Warfarin (Coumadin) is by far the most widely used anticoagulant medication.

  • It is taken by mouth and thus does not work as quickly as heparin. It takes about 48 hours to become effective.

  • The dosage of warfarin is important for successful treatment. Low doses may not be effective and high doses can cause bleeding. The dosage is adjusted on a daily basis for the first few days and then on a weekly basis. The dosage is adjusted by blood tests that assess clotting parameters.

  • While taking warfarin, the patient may undergo frequent blood tests to check how long it takes for blood to clot (prothrombin time). The prothrombin time is reported in a standardized form called the international normalized ratio (INR). The healthcare provider will aim to keep the patient's INR within a certain range (usually between 2-2.5) by adjusting the dose of warfarin.


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