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May 24, 2013
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Brain Lesions
(Lesions on the Brain)

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Brain Lesions Facts

  • Brain lesions (lesions on the brain) refers to any type of abnormal tissue in or on brain tissue.

  • Major types of brain lesions are traumatic, infectious, malignant, benign, vascular, genetic, immune, plaques, brain cell death or malfunction, and ionizing radiation. Other chemicals and toxins have been associated with brain lesions as well.

  • Brain lesions have many different causes that are related to the types listed above.

  • Risk factors for the development of brain lesions include any behaviors that increase the chances a person will suffer trauma to their head, exposure to certain infections, smoking and exposure to tobacco smoke, exposure to many types of chemicals and ionizing radiation, a poor diet and alcohol use. Genetic risk factors are unavoidable.

  • Signs and symptoms of most brain lesions are related to the type of lesion. However, some symptoms often found in patients with different types of brain lesions include headaches (recurrent or constant), nausea, vomiting, decreased appetite, changes in mood, changes in personality, behavioral changes, cognitive decline, inability to concentrate, vision problems, hearing and balance problems, muscle stiffness, weakness, numbness or paralysis, change or loss of sense of smell, memory loss, confusion, seizures, and coma.

  • Seek prompt medical care if any of the above symptoms develop.

  • Diagnosis of brain lesions begin with the patient's medical and family history, their signs and symptoms, and the physical exam. Usually several blood tests are ordered and many patients will undergo a CT scan or MRI of the brain. Definitive diagnosis for some brain lesions is based on examination of biopsy tissue taken from the brain lesion.

  • Treatment of brain lesions depends on the brain lesion type, the patient's age, their overall health problems, and the decision to proceed with a treatment plan agreed on by both the patient and their medical treatment team. Depending on the brain lesion type, treatment may include antibiotics, brain surgery, radiation therapy, chemotherapy, or a combination of these treatments. Other lesions have no effective treatment except for the use of medications that may reduce symptoms and impede the progression of the disease.

  • Complications of brain lesions may arise from the disease process itself or from the treatment modalities, and can range from minor complications (nausea and vomiting) to severe (symptoms become worse, seizures, coma, or even death).

  • Prognosis for brain lesions is highly variable depending on the type of lesion, the age and health condition of the patient, and how effective treatments are for the patient. The range of prognosis varies from good to poor, with the prognosis in some lesions declining as the patient's disease progressively worsens over time (usually years).

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Lesion Definition

Lesion: a lesion can be almost any abnormality involving any tissue or organ due to any disease or any injury.

There are, not surprisingly, many types of lesions. There are also a number of different ways of classifying and naming lesions. Lesions can, for instance, be categorized according to whether or not they are caused by cancer. A benign lesion is non-cancerous whereas a malignant lesion is cancerous. For example, a biopsy of a skin lesion may prove it to be benign or malignant, or evolving into a malignant lesion (called a premalignant lesion).

Lesions can be defined according to the patterns they form. For example, a bull's-eye or target lesion is one that looks like the bull's eye on a target. A coin lesion is a round shadow resembling a coin on a chest X-ray. It, too, is usually due to a tumor.

Lesions can also be categorized by their size. A gross lesion is one that can be seen with the naked eye. A microscopic or histologic lesion requires the magnification of a microscope to be seen. The basis of sickle cell disease is a molecular lesion, one that is not even visible with a microscope but is only detectable on the molecular (protein or DNA) level.

Location is another basis for naming lesions. In neurology, a central lesion involves the brain or spinal cord, i.e., the central nervous system. A peripheral lesion involves the nerves away from the spinal cord and does not involve the central nervous system.

There is a virtually endless assortment of lesions in medicine: primary lesions, secondary lesions, impaction lesions, indiscriminate lesions, irritative lesions, etc. Many are named for people including the Armanni-Ebstein lesion, a Bankart lesion, a Blumenthal lesion, and so on.

SOURCE:
MedTerms.com. Lesion.

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