Celiac Sprue (cont.)
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Celiac Disease Symptoms and Signs
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Gastrointestinal symptoms in children
Because celiac disease affects the absorption of nutrients essential for growth, children who are affected may have impaired growth and consequently short stature. Other common signs and symptoms include the following:
The onset of symptoms is usually gradual and coincides with the introduction of cereal into the diet. The symptoms usually diminish in adolescence.
Gastrointestinal symptoms in adults
Celiac disease usually affects adults in the third to fourth decade of life but sometimes later. The signs and symptoms of celiac disease are variable and may include the following:
Malabsorption of ingested fat results in the delivery of excessive dietary fat to the large bowel. The bacteria in the colon feast on the fats and other undigested and unabsorbed nutrients, generating intestinal gas resulting in bloating and flatulence. In addition, other substances are released, causing secretion of fluid into the intestine and hence diarrhea. Fatigue (tiredness) and weakness can result from the loss of electrolytes, such as potassium and magnesium, due to the diarrhea.
Nutrient and vitamin deficiencies
Iron and folic acid are essential for the production of normal red blood cells (erythrocytes). Abnormalities in the absorption of iron or folic acid may result in anemia (low red blood cell count). Vitamin B-12 deficiencies can also contribute to the anemia noticed in affected persons with a mechanism similar to that of iron and folic acid deficiencies.
Vitamin deficiencies may develop when malabsorption is present. Vitamins soluble in fat are commonly malabsorbed. These include vitamins K and D.
Nongastrointestinal (extraintestinal) features
Skin disorders can complicate the course of the celiac disease. These conditions include dermatitis herpetiformis, an itchy skin condition characterized by a rash or blisters involving the extremities, the trunk, the buttocks, the scalp, and the neck.
Medically Reviewed by a Doctor on 5/26/2016
Mohammed Wehbi, MD
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