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February 10, 2012
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Chronic Fatigue Syndrome (cont.)

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Chronic Fatigue Syndrome Treatment

There are many described therapies for chronic fatigue syndrome. Because the cause of chronic fatigue syndrome is unknown, treatment programs are directed at relief of symptoms rather than cure. The goal is to regain some level of preexisting function and well-being. With this in mind, many people with CFS do not quickly return to a satisfactory level of function. People who expect a prompt recovery and do not experience it may have worsening CFS symptoms because they work too hard, become frustrated, and become less responsive to rehabilitation programs.

Always talk to your doctor about any treatment decisions for CFS. You and your doctor together will develop a treatment program individually tailored to your needs. The treatment program should be based on your overall medical condition and current symptoms and should be modified over time as your symptoms change. This requires regular follow-up visits to your doctor to monitor changes in your condition. Currently, most doctors use a combination of the therapies discussed below.

Self-Care at Home

Physical activity performed at a comfortable pace is important for everyone to maintain good health, including people with chronic fatigue syndrome. People with CFS need to learn how much activity is helpful and when to stop, so they do not increase their level of fatigue.

In general, people with CFS should pace themselves carefully and avoid excessive physical or emotional stress. Remember, the goal is to avoid increasing fatigue or pain. Maintain a regular and manageable daily routine to avoid a relapse or increase of symptoms. Exercise should be supervised by a knowledgeable health-care provider or physical therapist.

Total rest should also be avoided as it may make your fatigue worse. You should maintain physical activity at a comfortable pace. If you increase your level of physical activity, do so gradually.

Decreased consumption of alcohol and caffeine at night may help you sleep.

Try to minimize social isolation.

Medical Treatment

Medical therapy is designed to relieve the specific symptoms of chronic fatigue syndrome. People with CFS are often sensitive to many medications, especially those that affect the central nervous system. Usually, your doctor will begin with low doses of medication and gradually increase the dose depending on side effects and your response to the medication. Because drug therapy is directed at symptom relief, medications should only be used in CFS if all other causes of the symptom have been ruled out. Remember that all medications can cause side effects. Talk to your doctor before beginning any new medication and if any side effect develops.

NSAIDs, for pain relief. Some are available without a prescription, including naproxen (Aleve) and ibuprofen (Advil, Bayer Select, Motrin, Nuprin). Prescription drugs include tramadol hydrochloride (Ultram), celecoxib (Celebrex), and other naproxen-containing medications (Anaprox, Naprosyn).

  • Low-dose tricyclic antidepressants: These medications may improve sleep and relieve mild generalized pain. Examples include doxepin (Adapin, Sinequan), amitriptyline (Elavil, Etrafon, Limbitrol, Triavil), desipramine (Norpramin), and nortriptyline (Pamelor).


  • Other antidepressants: Newer antidepressants have been used to treat depression in people with chronic fatigue syndrome. These antidepressants include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), venlafaxine (Effexor), trazodone (Desyrel), and bupropion (Wellbutrin).


  • Anxiolytic agents: These medications are used to treat anxiety in people with CFS. Examples include alprazolam (Xanax) and lorazepam (Ativan).


  • Stimulants: Stimulants may be used to treat lethargy or daytime sleepiness. Studies using modafinil (Provigil) have been completed, but the results have not been published, and currently this drug is only indicated for narcolepsy (brief attacks of deep sleep) and excess daytime sleepiness in patients identified in proper sleep studies.


  • Antimicrobials: A specific infection as a cause for chronic fatigue syndrome has not been identified, and antibiotic, antiviral, and antifungal drugs should not be prescribed for treatment of CFS in general. However, in people with elevated C. pneumoniae levels, particularly increased IgM titers, antibiotic therapy with doxycycline (Doryx, Doxy) may be effective.


  • Anti-allergy therapy: Some people with CFS have allergies that periodically flare up. Nonsedating antihistamines may be helpful and include desloratadine (Clarinex), fexofenadine (Allegra), and cetirizine (Zyrtec). However, allergy therapy does not treat CFS itself.
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