Kidney Disease Glossary of Terms
The following are health and medical definitions of terms that appear in the Kidney Disease article.
Abdomen: The belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs. Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs. Abdominal cavity: The cavity within the abdomen, the space between the abdominal wall and the spine. Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer). Absorption: Uptake. In the biomedical sciences, absorption has diverse specific meanings. Acetaminophen: A pain reliever and fever reducer. Brand name: Tylenol. The exact mechanism of action of acetaminophen is not known. Acetaminophen relieves pain by elevating the pain threshold (that is, by requiring a greater amount of pain to develop before it is felt by a person). Acetaminophen reduces fever through its action on the heat-regulating center (the "thermostat") of the brain. Generic is available. Acid-base balance: Acid-base balance refers to the mechanisms the body uses to keep its fluids close to neutral pH (that is, neither basic nor acidic) so that the body can function normally. Acidosis: Too much acid in the body, a distinctly abnormal condition resulting from the accumulation of acid or from the depletion of alkaline reserves. In acidosis, the pH of the blood is abnormally low. Acidosis is associated with diabetic ketoacidosis, lung disease, and severe kidney disease. The opposite of acidosis is alkalosis in which there is too high a pH due to excess base or insufficient acid in the body. Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care. Acute kidney failure: See: Acute renal failure. Aging: The process of becoming older, a process that is genetically determined and environmentally modulated. Albumin: The main protein in human blood and the key to the regulation of the osmotic pressure of blood. Chemically, albumin is soluble in water, precipitated by acid, and coagulated by heat. Aluminum: A naturally occurring element that makes up about 8% of the surface of the earth and is always found combined with other elements such as oxygen, silicon, and fluorine. Aluminum is is the most common metallic element in the earth's crust but has no clear biologic role. Everyone is exposed to low levels of aluminum from food, air, and water. Exposure to high levels of aluminum may result in respiratory problems (aluminosis). Inhalation of bauxite (aluminum ore) fumes may cause pulmonary fibrosis. Aluminum in the bloodstream may lead to neurological symptoms and may be fatal. Ambulatory: Able to ambulate, to walk about, not bed-ridden or hospitalized. Amyloidosis: A disorder that results from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area, and not be harmful, or in can cause serious changes in virtually any organ of the body. Analgesic: A drug or medicine given to reduce pain without resulting in loss of consciousness. Analgesics are sometimes referred to as painkiller medications. There are many different types of analgesic medications available in both prescription and over-the-counter preparations. Examples of analgesic drugs include aspirin, acetaminophen (Tylenol), ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), the COX-2 inhibitor celecoxib, and narcotic drugs including morphine, oxycodone, and hydrocodone (Vicodin). Analgesics may also be combined with other drugs in some types of medications (for example, analgesics are combined with decongestants and/or antihistamine in many over-the-counter cold remedies). Analysis: A psychology term for processes used to gain understanding of complex emotional or behavioral issues. Anatomy: The study of form. Gross anatomy involves structures that can be seen with the naked eye. It is as opposed to microscopic anatomy (or histology) which involves structures seen under the microscope. Traditionally, both gross and microscopic anatomy have been studied in the first year of medical school in the U.S. The most celebrated textbook of anatomy in the English-speaking world is Gray's Anatomy, still a useful reference book. The word "anatomy" comes from the Greek ana- meaning up or through + tome meaning a cutting. Anatomy was once a "cutting up" because the structure of the body was originally learned through dissecting it, cutting it up. The abbreviation for anatomy is anat. Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased. Anesthesia: Loss of feeling or awareness. A general anesthetic puts the person to sleep. A local anesthetic causes loss of feeling in a part of the body such as a tooth or an area of skin without affecting consciousness. Regional anesthesia numbs a larger part of the body such as a leg or arm, also without affecting consciousness. The term "conduction anesthesia" encompasses both local and regional anesthetic techniques. Many surgical procedures can be done with conduction anesthesia without significant pain. In many situations, such as a C-section, conduction anesthesia is safer and therefore preferable to general anesthesia. However, there are also many types of surgery in which general anesthesia is clearly appropriate. Angiotensin: A family of peptides (smaller than proteins) that act as vasoconstrictors to narrow blood vessels. Angiotensin converting enzyme: Usually abbreviated ACE. Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red. Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid. Atherosclerosis: A process of progressive thickening and hardening of the walls of medium-sized and large arteries as a result of fat deposits on their inner lining. Bicarbonate: In medicine, bicarbonate usually refers to bicarbonate of soda (sodium bicarbonate, baking soda) white powder that is common ingredient in antacids. Also, the bicarbonate level is an indirect measure of the acidity of the blood that is determined when electrolytes are tested. The normal serum range for bicarbonate is 22-30 mmol/L. Biopsy: The removal of a sample of tissue for purposes of diagnosis. (Many definitions of "biopsy" stipulate that the sample of tissue is removed for examination under a microscope. This may or may not be the case. The diagnosis may be achieved by other means such as by analysis of chromosomes or genes.) Bladder: Any pouch or other flexible enclosure that can hold liquids or gases but usually refers to the hollow organ in the lower abdomen that stores urine -- the urinary bladder. The kidneys filter waste from the blood and produce urine, which enters the bladder through two tubes called ureters. Urine leaves the bladder through another tube, the urethra. In women, the urethra is a short tube that opens just in front of the vagina. In men, it is longer, passing through the prostate gland and then the penis. Infection of the bladder is called cystitis. Blood glucose: The main sugar that the body makes from the food in the diet. Glucose is carried through the bloodstream to provide energy to all cells in the body. Cells cannot use glucose without the help of insulin. Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension". 
Blood urea nitrogen: Abbreviated BUN. A measure primarily of the urea level in blood. Urea is cleared by the kidney. Diseases that compromise the function of the kidney frequently lead to an increased BUN. Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells. Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation. Calcitriol: The active form of vitamin D. Calcitriol is formed in the kidneys or made in the laboratory. It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders. Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily. Learn more about calcium with evidence-based information on RxList.Cancer: An abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some cases, to metastasize (spread). CAPD: Central auditory processing disorder. Capillaries: Capillaries are the smallest of blood vessels. They serve to distribute oxygenated blood from arteries to the tissues of the body and to feed deoxygenated blood from the tissues back into the veins. The capillaries are thus a central component in the circulatory system, essentially between the arteries and the veins. When pink areas of skin are compressed, this causes blanching because blood is pressed out of the capillaries. The blood is the fluid in the body that contains, among other elements, the red blood cells (erythrocytes) that carry the oxygen and give the blood its red color. Capillary: One of the tiny blood vessels that connect the arterioles (the smallest divisions of the arteries) and the venules (the smallest divisions of the veins). The capillaries form a fine network in many parts of the body. Capsule: Capsule has many meanings in medicine including the following:
See the entire definition of Capsule Catheter: A thin, flexible tube. For example, a catheter placed in a vein provides a pathway for giving drugs, nutrients, fluids, or blood products. Samples of blood can also be withdrawn through the catheter. CDC: The Centers for Disease Control and Prevention, the US agency charged with tracking and investigating public health trends. The stated mission of the CDC is "To promote health and quality of life by preventing and controlling disease, injury, and disability." The CDC is a part of the U.S. Public Health Services (PHS) under the Department of Health and Human Services (HHS). Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane. Central venous catheter: See: Catheter, central venous. Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum. Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention. Cholesterol: The most common type of steroid in the body, cholesterol has gotten something of a bad name. However, cholesterol is a critically important molecule. Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time. Chronic kidney failure: See: Chronic renal failure. Chronic renal failure: Slow progressive loss of kidney function over the span of years, resulting in permanent kidney failure. Chronic kidney disease is common and may go undiagnosed until the process is far advanced and renal failure is on the horizon. People with permanent kidney failure need dialysis or a transplanted kidney to do the work of their failed kidneys. Circulation: The movement of fluid in a regular or circuitous course. Although the noun "circulation" does not necessarily refer to the circulation of the blood, for all practical purposes today it does. Heart failure is an example of a problem with the circulation. Complication: In medicine, an additional problem that arises following a procedure, treatment or illness and is secondary to it. A complication complicates the situation. Creatinine: A chemical waste molecule that is generated from muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Approximately 2% of the body's creatine is converted to creatinine every day. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out most of the creatinine and dispose of it in the urine. Cure: 1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm. Cysts: Cysts are abnormal, closed sac-like structures within a tissue that contain a liquid, gaseous, or semisolid substance. Cysts can occur anywhere in the body and can vary in size. The outer, or capsular, portion of a cyst is termed the cyst wall. Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria). Diabetes mellitus: Better known just as "diabetes" -- a chronic disease associated with abnormally high levels of the sugar glucose in the blood. Diabetes is due to one of two mechanisms: Diabetic nephropathy: The kidney disease associated with long-standing diabetes. Diabetic nephropathy is also called Kimmelstiel-Wilson disease (or Kimmelstiel-Wilson syndrome) or intercapillary glomerulonephritis. Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV. Dialysis: The process of cleansing the blood by passing it through a special machine. Dialysis is necessary when the kidneys are not able to filter the blood. Dialysis allows patients with kidney failure a chance to live productive lives. There are two types of dialysis: hemodialysis and peritoneal dialysis. Each type of dialysis has advantages and disadvantages. Patients can often choose the type of long term dialysis that best matches their needs.
Dialysis machine: A machine that filters a patient's blood to remove excess water and waste products when the kidneys are damaged, dysfunctional, or missing. Blood is drawn through a specially created vein in the forearm, which is called an arterio-venous (AV) fistula. From the AV fistula, blood is taken to the dialysis machine through plastic tubing. The dialysis machine itself can be thought of as an artificial kidney. Inside, it consists of more plastic tubing that carries the removed blood to the dialyser, a bundle of hollow fibers that forms a semipermeable membrane for filtering out impurities. In the dialyser, blood is diffused with a saline solution called dialysate, and the dialysate is in turn diffused with blood. Once the filtration process is complete, the cleansed blood is returned to the patient. Most patients using dialysis due to kidney impairment or failure use a dialysis machine at a special dialysis clinic. Most sessions take about four hours, and typically patients visit the clinic one to three times per week. Diuretic: Anything that promotes the formation of urine by the kidney. (The word "diuretic" comes from a combination of the Greek "dia-", thoroughly + "ourein", to urinate = to urinate thoroughly). Donor: The giver of a tissue or organ, for example, of blood or a kidney. Dysfunction: Difficult function or abnormal function. Dysplasia: Abnormal in form. From the Greek dys- (bad, disordered, abnormal) and plassein (to form). For example, retinal dysplasia is abnormal formation of the retina during embryonic development. EGFR: Epidermal growth factor receptor. A protein found on the surface of cells to which epidermal growth factor (EGF) binds. When EGF attaches to EGFR, it activates the enzyme tyrosine kinase, triggering reactions that cause the cells to grow and multiply. EGFR is found at abnormally high levels on the surface of many types of cancer cells, which may divide excessively in the presence of EGF. The drug Iressa attaches to EGFR and thereby inhibits the attachment of EGF and stops cell division. The gene for EGFR is on chromosome 7p12.3-p12.1. The EGFR molecule has 3 regions -- one projects outside the cell and contains the site for binding EGF; the second is embedded in the cell membrane; and the third projects into the cytoplasm of the cell's interior. EGFR is a kinase that attaches phosphate groups to tyrosine residues in proteins. EGFR is also known confusingly as ErbB1, ErbB, oncogene ErbB, and HER1. Electrolyte: An electrolyte is a substance that will dissociate into ions in solution and acquire the capacity to conduct electricity. The electrolytes include sodium, potassium, chloride, calcium and phosphate. Informally, called lytes. (The clue to the word electrolyte is in the lyte which comes from the Greek lytos meaning that may be dissolved.) Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests. Encephalopathy: Disease, damage, or malfunction of the brain. In general, encephalopathy is manifested by an altered mental state that is sometimes accompanied by physical changes. Although numerous causes of encephalopathy are known, the majority of cases arise from infection, liver damage, anoxia, or kidney failure. The term encephalopathy is very broad and, in most cases, is preceded by various terms that describe the reason, cause, or special conditions of the patient that leads to brain malfunction. For example, anoxic encephalopathy means brain damage due to lack of oxygen, and hepatic encephalopathy means brain malfunction due to liver disease. Depending upon the cause and severity of the condition, symptoms may range from mild alterations in mental status to severe and potentially fatal manifestations such as dementia, seizures, and coma. End-stage renal disease: ESRD. Chronic irreversible renal failure. Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist. Erectile dysfunction: A common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse or the inability to achieve ejaculation, or both. Impotence can vary. It can involve a total inability to achieve an erection or ejaculation, an inconsistent ability to do so, or a tendency to sustain only very brief erections. Erectile dysfunction is also called impotence, Essential: 1. Something that cannot be done without. Family history: The family structure and relationships within the family, including information about diseases in family members. Fatigue: A condition characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness and tiredness. Fatigue can be acute and come on suddenly or chronic and persist. Fatty acids: Molecules that are long chains of lipid-carboxylic acid found in fats and oils and in cell membranes as a component of phospholipids and glycolipids. (Carboxylic acid is an organic acid containing the functional group -COOH.) Fiber: The parts of plants that cannot be digested, namely complex carbohydrates. Also known as bulk or roughage. Fistula: An abnormal passageway in the body. The fistula may go from the body surface into a blindpouch or into an internal organ or go between two internal organs. Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines. Glomerular: Pertaining to the glomerulus, a tiny structure in the kidney that filters the blood to form urine. Glomeruli: The plural of glomerulus. Glomerulus: 1.In the kidney, a tiny ball-shaped structure composed of capillary blood vessels actively involved in the filtration of the blood to form urine. The glomerulus is one of the key structures that make up the nephron, the functional unit of the kidney. Glucose: The simple sugar (monosaccharide) that serves as the chief source of energy in the body. Glucose is the principal sugar the body makes. The body makes glucose from proteins, fats and, in largest part, carbohydrates. Glucose is carried to each cell through the bloodstream. Cells, however, cannot use glucose without the help of insulin. Glucose is also known as dextrose. Graft: Healthy skin, bone, or other tissue taken from one part of the body to replace diseased or injured tissue removed from another part of the body. Groin: In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh. Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest. Heart disease: Any disorder that affects the heart. Sometimes the term "heart disease" is used narrowly and incorrectly as a synonym for coronary artery disease. Heart disease is synonymous with cardiac disease but not with cardiovascular disease which is any disease of the heart or blood vessels. Among the many types of heart disease, see, for example: Angina; Arrhythmia; Congenital heart disease; Coronary artery disease (CAD); Dilated cardiomyopathy; Heart attack (myocardial infarction); Heart failure; Hypertrophic cardiomyopathy; Mitral regurgitation; Mitral valve prolapse; and Pulmonary stenosis. Hemodialysis: A medical procedure that uses a special machine (a dialysis machine) to filter waste products from the blood and to restore normal constituents to it. This shuffling of multiple substances is accomplished by virtue of the differences in the rates of their diffusion through a semipermeable membrane (a dialysis membrane). Hemoglobin: The oxygen-carrying pigment and predominant protein in the red blood cells. Hemoglobin forms an unstable, reversible bond with oxygen. In its oxygenated state it is called oxyhemoglobin and is bright red. In the reduced state it is called deoxyhemoglobin and is purple-blue. Herbal: 1. An adjective, referring to herbs, as in an herbal tea.
Heroin: Semisynthetic drug derived from morphine. Discovered in 1874, it was introduced commercially in 1898 by the Bayer company in Germany. The name heroin was coined from the German heroisch meaning heroic, strong. Heroin is stronger (more potent) than morphine. High blood pressure: Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism). Hormone: A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Hyperkalemia: Elevated blood potassium. Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever. Common brand names for Ibuprofen include Advil, Motrin, and Nuprin. Immune: Protected against infection. The Latin immunis means free, exempt. Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders. Immunosuppressant: An agent that can suppress or prevent the immune response. Immunosuppressants are used to prevent rejection of a transplanted organ and to treat autoimmune diseases such as psoriasis, rheumatoid arthritis, and Crohn's disease. Some treatments for cancer act as immunosuppressants. Also called an immunodepressant. Implantation: The act of setting in firmly. Incidence: The frequency with which something, such as a disease, appears in a particular population or area. In disease epidemiology, the incidence is the number of newly diagnosed cases during a specific time period. The incidence is distinct from the prevalence which refers to the number of cases alive on a certain date. Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person. Inflammation: A basic way in which the body reacts to infection, irritation or other injury, the key feature being redness, warmth, swelling and pain. Inflammation is now recognized as a type of nonspecific immune response. Injury: Harm or hurt. The term "injury" may be applied in medicine to damage inflicted upon oneself as in a hamstring injury or by an external agent on as in a cold injury. The injury may be accidental or deliberate, as with a needlestick injury. The term "injury" may be synonymous (depending on the context) with a wound or with trauma.
Internal medicine: A medical specialty dedicated to the diagnosis and medical treatment of adults. A physician who specializes in internal medicine is referred to as an internist. A minimum of seven years of medical school and postgraduate training are focused on learning the prevention, diagnosis, and treatment of diseases of adults. Subspecialties of internal medicine include allergy and immunology, cardiology (heart), endocrinology (hormone disorders), hematology (blood disorders), infectious diseases, gastroenterology (diseases of the gut), nephrology (kidney diseases), oncology (cancer), pulmonology (lung disorders), and rheumatology (arthritis and musculoskeletal disorders). Iron: An essential mineral. Iron is necessary for the transport of oxygen (via hemoglobin in red blood cells) and for oxidation by cells (via cytochrome). Deficiency of iron is a common cause of anemia. Food sources of iron include meat, poultry, eggs, vegetables and cereals (especially those fortified with iron). According to the National Academy of Sciences, the Recommended Dietary Allowances of iron are 15 milligrams per day for women and 10 milligrams per day for men. Iron overload can damage the heart, liver, gonads and other organs. Iron overload is a particular risk in people who may have certain genetic conditions (hemochromatosis) sometimes without knowing it and also in people receiving recurrent blood transfusions. Iron supplements meant for adults (such as pregnant women) are a major cause of poisoning in children. Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area. Joint: A joint is the area where two bones are attached for the purpose of motion of body parts. A joint is usually formed of fibrous connective tissue and cartilage. An articulation or an arthrosis is the same as a joint. Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination. See the entire definition of Kidney Kidney transplant: Replacement of a diseased, damaged, or missing kidney with a donor kidney. Also called a renal transplant. Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems." Lightheadedness: A feeling you are "going to faint." Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo. See: Dizziness, Unsteadiness, and Vertigo. Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick. See the entire definition of Liver Liver disease: Liver disease refers to any disorder of the liver. The liver is a large organ in the upper right abdomen that aids in digestion and removes waste products from the blood. Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung. Lupus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues. Magnesia: Named after a town in present day Turkey where an ore containing magnesium carbonate was mined. Milk of Magnesia, the laxative, is magnesium hydroxide. Magnesium: A mineral involved in many processes in the body including nerve signaling, the building of healthy bones, and normal muscle contraction. About 350 enzymes are known to depend on magnesium. Marrow: The bone marrow.
Membrane: A very thin layer of tissue that covers a surface. Metabolic: Relating to metabolism, the whole range of biochemical processes that occur within us (or any living organism). Metabolism consists of anabolism (the buildup of substances) and catabolism (the breakdown of substances). Microscope: An optical instrument that augments the power of the eye to see small objects. The name microscope was coined by Johannes Faber (1574-1629) who in 1628 borrowed from the Greek to combined micro-, small with skopein, to view. Although the first microscopes were simple microscopes, most (if not all) optical microscopes today are compound microscopes. Microscopic: So small it cannot be seen without the aid of microscope. As opposed to macroscopic (large enough to be seen with naked eye). A tiny tumor is microscopic while a big tumor is macroscopic. Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral. Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle." Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted. Neck: The part of the body joining the head to the shoulders. Also, any narrow or constricted part of a bone or organ that joins its parts as, for example, the neck of the femur bone. Nephritis: Inflammation of the kidney. Nephritis can be acute or chronic. Nephrology: The art and science of the care of the kidney. Nephron: A key unit, both anatomically and functionally, of the kidney. Nephropathy: Any kidney disease. For example, there is diabetic nephropathy, gouty nephropathy, HIV-associated nephropathy, ischemic nephropathy, sickle cell nephropathy,and so on. From the Greek "nephros" (kidney) + "pathos" (disease). Neuropathy: Any and all disease or malfunction of the nerves. Nitrogen: Element number 7, a colorless, odorless, tasteless gas that is biologically important. Nitrogen is a constituent of protein and nucleic acids and is present in all living cells. Nitrogen does not support respiration and is fatal if breathed alone, because of the lack of oxygen. Nitrogen is soluble in the blood and body fluids and, when released as bubbles of gas, can have serious or even fatal consequences. Nocturia: Excessive urinating at night. People with nocturia must get up, often two times or more, during the night to urinate. Normally, urine is more concentrated at night and is produced in lower amounts, so that uninterrupted sleep is possible. However, excess urine production at night can occur due to a number of conditions including diabetes, urinary tract infection, bladder infection, kidney failure, prostatic hyperplasia, taking certain medications, or sleep disorders. Treatment of nocturia is dependent upon the underlying cause.
Obesity: The state of being well above one's normal weight. Obstruction: Blockage of a passageway. See, for example: Airway obstruction; Intestinal obstruction. Organ: A relatively independent part of the body that carries out one or more special functions. The organs of the human body include the eye, ear, heart, lungs, and liver. Osteodystrophy: A bone disorder that adversely affects bone growth. See also renal osteodystrophy. Outpatient: A patient who is not an inpatient (not hospitalized) but instead is cared for elsewhere -- as in a doctor's office, clinic, or day surgery center. The term outpatient dates back at least to 1715. Outpatient care today is also called ambulatory care. Ovarian: Of or pertaining to the ovary. Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors. Pericarditis: Inflammation of the lining around the heart (the pericardium) causing chest pain and accumulation of fluid around the heart (pericardial effusion). Peripheral: Situated away from the center, as opposed to centrally located. Peripheral neuropathy: A problem with the functioning of the nerves outside the spinal cord. Symptoms may include numbness, weakness, burning pain (especially at night), and loss of reflexes. Peritoneal: Having to do with the peritoneum. Peritoneal dialysis: Technique that uses the patient's own body tissues inside of the belly (abdominal cavity) to act as a filter. The intestines lie in the abdominal cavity, the space between the abdominal wall and the spine. A plastic tube called a "dialysis catheter" is placed through the abdominal wall into the abdominal cavity. A special fluid is then flushed into the abdominal cavity and washes around the intestines. The intestinal walls act as a filter between this fluid and the blood stream. By using different types of solutions, waste products and excess water can be removed from the body through this process. Peritoneum: The membrane that lines the abdominal cavity and covers most of the abdominal organs. (From the Greek peri- meaning around + tonos meaning a stretching = a stretching around). Phosphorus: An essential element in the diet and a major component of bone. Phosphorus is also found in the blood, muscles, nerves, and teeth. It is a component of adenosine triphosphate (ATP), the primary energy source in the body. Polycystic kidney disease: One of the genetic disorders characterized by the development of innumerable cysts in the kidneys. These cysts are filled with fluid, and replace much of the mass of the kidneys. This reduces kidney function, leading to kidney failure. Potassium: The major positive ion (cation) found inside of cells. The chemical notation for potassium is K+. Pound: A measure of weight equal to 16 ounces or, metrically, 453.6 grams. The word "pound" goes back to the Latin "pondo" which meant a "weight" (but one of only 12 ounces). The abbreviation for pound-just to confuse non-pound people-is lb. which stands for "libra" (Latin for pound). Pregnant: The state of carrying a developing fetus within the body. Prevalence: The proportion of individuals in a population having a disease. Prevalence is a statistical concept referring to the number of cases of a disease that are present in a particular population at a given time. Prognosis: 1. The expected course of a disease. Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse. Prostate: A gland within the male reproductive system that is located just below the bladder. Chestnut shaped, the prostate surrounds the beginning of the urethra, the canal that empties the bladder. Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. Proteins: Large molecules composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein. Quality of life: An important consideration in medical care, quality of life refers to the patient's ability to enjoy normal life activities. Some medical treatments can seriously impair quality of life without providing appreciable benefit, while others greatly enhance quality of life. Receptor: 1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterol metabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions. Recipient: In medicine, a recipient is someone who receives something like a blood transfusion or an organ transplant. The recipient is beholden to the donor. Red blood cell: The blood cell that carries oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cell its red color (and name). Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name). Red cells: Short for red blood cells, the oxygen/carbon dioxide carrying cells in blood. Also known acronymically as RBC's, red corpuscles or erythrocytes (literally, red hollow vessels).
Reflux: The term used when liquid backs up into the esophagus from the stomach. Renal: Having to do with the kidney. From the Latin renes (the kidneys), which gave the French les reins which mean both the kidneys and the lower back. Renal osteodystrophy: A combination of bone disorders usually caused by chronic kidney failure (renal disease). Can also occur because of abnormal kidney functioning at birth (congenital). When the kidneys have failed, death is imminent unless dialysis is given. Therefore, patients with osteodystrophy are usually on dialysis therapy. This bone disease, which is also simply called osteodystrophy, is common in patients on chronic hemodialysis. Residual: Something left behind. With residual disease, the disease has not been eradicated. Restless legs: See: Restless leg syndrome. Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma. Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea. Sickle cell disease: A genetic blood disorder caused by the presence of an abnormal form of hemoglobin. These hemoglobin molecules tend to aggregate after unloading oxygen forming long, rod-like strictures that force the red cells to assume a sickle shape. Unlike normal red cells, which are usually smooth and malleable, the sickle red cells cannot squeeze through small blood vessels. When the sickle cells block small blood vessels, the organs are deprived of blood and oxygen. This leads to periodic episodes of pain and damages the vital organs. Sickle red cells die after only about 10 to 20 days. Instead of the usual 120 days or so. Because they cannot be replaced fast enough, the blood is chronically short of red cells, causing anemia. The gene for sickle cell anemia must be inherited from both parents for the illness to occur in children. A child with only one copy of the gene may have sickle-cell traits but no symptoms of illness. Sleep: The body's rest cycle. Sodium: The major positive ion (cation) in fluid outside of cells. The chemical notation for sodium is Na+. When combined with chloride, the resulting substance is table salt. Spine: 1) The column of bone known as the vertebral column, which surrounds and protects the spinal cord. The spine can be categorized according to level of the body: i.e., cervical spine (neck), thoracic spine (upper and middle back), and lumbar spine (lower back). See also vertebral column. 2) Any short prominence of bone. The spines of the vertebrae protrude at the base of the back of the neck and in the middle of the back. These spines protect the spinal cord from injury from behind. Stage: As regards cancer, the extent of a cancer, especially whether the disease has spread from the original site to other parts of the body. See also: Staging. Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office. Symptomatic: 1 With symptoms, as a symptomatic infection. 2 Characteristic, as behavior symptomatic of Huntington disease. 3 Directed at the symptoms, as symptomatic treatment. Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease. Systemic: Affecting the entire body. A systemic disease such as diabetes can affect the whole body. Systemic chemotherapy employs drugs that travel through the bloodstream and reach and affect cells all over the body. Systemic lupus erythematosus: A chronic inflammatory condition caused by an autoimmune disease. An autoimmune disease occurs when the body's tissues are attacked by its own immune system. Patients with lupus have unusual antibodies in their blood that are targeted against their own body tissues. Therapy: The treatment of disease. Transplant: The grafting of a tissue from one place to another, just as in botany a bud from one plant might be grafted onto the stem of another. The transplanting of tissue can be from one part of the patient to another (autologous transplantation), as in the case of a skin graft using the patient's own skin; or from one patient to another (allogenic transplantation), as in the case of transplanting a donor kidney into a recipient. Tubes: The "tubes" are medically known as the Fallopian tubes. There are two Fallopian tubes, one on each side, which transport the egg from the ovary to the uterus (the womb). The Fallopian tubes have small hair-like projections called cilia on the cells of the lining. Tubule: A small tube. Tylenol: See: Acetaminophen. Type 2 diabetes: See Diabetes, type 2. Ulcer: An area of tissue erosion, for example, of the skin or lining of the gastrointestinal (GI) tract. Due to the erosion, an ulcer is concave. It is always depressed below the level of the surrounding tissue. Ultrasound: High-frequency sound waves. Ultrasound waves can be bounced off of tissues using special devices. The echoes are then converted into a picture called a sonogram. Ultrasound imaging, referred to as ultrasonography, allows physicians and patients to get an inside view of soft tissues and body cavities, without using invasive techniques. Ultrasound is often used to examine a fetus during pregnancy. There is no convincing evidence for any danger from ultrasound during pregnancy. Urea: A nitrogen-containing substance normally cleared from the blood by the kidney into the urine. Diseases that compromise the function of the kidney often lead to increased blood levels of urea, as measured by the blood urea nitrogen (BUN) test. Urethra: The transport tube leading from the bladder to discharge urine outside the body. In males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter than in the male and emerges above the vaginal opening, as indicated here: Urinalysis: A test that determines the content of the urine. Because urine removes toxins and excess liquids from the body, it can contain important clues. Urinalysis can be used to detect some types of disease, particularly in the case of metabolic disorders and kidney disease. It can also be used to uncover evidence of drug abuse. Urinary: Having to do with the kidneys, ureters, and bladder. The urinary system represents the functional and anatomic aspects of the kidneys, ureters, and bladder. Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.
Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system. Vasculitis: Plural: vasculitides. A general term for a group of diseases that feature inflammation of the blood vessels. Each of these diseases is defined by characteristic distributions of blood vessel involvement, patterns of organ involvement, and laboratory test abnormalities. The causes of these vasculitis diseases are usually not known, but immune system abnormality is a common feature. Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart. Vessel: A tube in the body that carries fluids: blood vessels or lymph vessels. Vitamin D: A steroid vitamin which promotes the intestinal absorption and metabolism of calcium and phosphorus. Under normal conditions of sunlight exposure, no dietary supplementation is necessary because sunlight promotes adequate vitamin D synthesis in the skin. Deficiency can lead to bone deformity (rickets) in children and bone weakness (osteomalacia) in adults. Vitamins: The word "vitamin" was coined in 1911 by the Warsaw-born biochemist Casimir Funk (1884-1967). At the Lister Institute in London, Funk isolated a substance that prevented nerve inflammation (neuritis) in chickens raised on a diet deficient in that substance. He named the substance "vitamine" because he believed it was necessary to life and it was a chemical amine. The "e" at the end was later removed when it was recognized that vitamins need not be amines. Water retention: A nonspecific term meaning the accumulation of excess fluids in body tissues, medically known as edema. Edema can result from many different disease processes, including but not limited to diseases of the heart and circulation and kidney disease.
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Encephalopathy Overview
Encephalopathy is a broad term used to describe abnormal brain function or structure. (Encephalo= brain +pathy= disorder). The abnormality may be transient, recurrent, or permanent. The loss of brain function may be reversible, static and stable, or progressive with increasing loss of brain activity.
Normal brain function
Brain cells are linked together with neurons called axons and dendrites covered in myelin sheaths. The electrical impulses work together with chemical receptors to allow brain activity to translate in to thought and action. Different locations in the brain specialize with respect to function, for example, vision function is located in the occipital lobes, speech production in Broca's area in the lower part of the frontal lobe, speech recognition is located in Wernicke's area of the temporal lobe, and the motor strip in the parietal lobes...
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