Chronic Obstructive Pulmonary Disease (COPD) (cont.)
IN THIS ARTICLE
Cigarette Smoking or Exposure to Tobacco Smoke
Cigarette smoking or exposure to tobacco smoke is the primary cause of COPD. While COPD occurs in 15% of cigarette smokers, tobacco use accounts for as much as 90% of the risk for the development of this disease.
People with COPD experience a more rapid decline in what is called forced expiratory volume, or FEV. FEV is the maximum volume of air that can be exhaled within a specified time period, starting from maximal inhalation. A subscript indicates the time period in seconds. For example, FEV1 is the maximum volume of air that can be exhaled within 1 second. A decline in FEV causes a person to become short of breath and to have difficulty breathing.
It is not clear if air pollution causes COPD. However, if it does, the effect is small when compared to cigarette smoking.
The use of solid fuels for cooking and heating may cause high levels of indoor air pollution, which may then lead to the development of COPD, especially in underdeveloped countries where cooking with wood or coal is common.
Some patients who develop COPD have airway hyperresponsiveness, a condition in which their airways overreact to airborne irritants, such as secondhand smoke and air pollution.
The role of airway hyperresponsiveness as a risk factor for COPD in people who smoke is unclear. However, according to one hypothesis, patients who have airway hyperreactivity and who smoke are at an increased risk of COPD and an accelerated rate of decreased lung function.
In patients with chronic asthma, inflammation over time can result in permanent remodeling of the airways and result in fixed airway obstruction. It is in this way that chronic asthma becomes COPD. Generally, patients with asthma have normal lung function when they are not having an attack. It is only after years of inadequate control of airway inflammation that they can develop this fixed airway obstruction.
Alpha1-Antitrypsin (AAT) Deficiency
Alpha1-antitrypsin (AAT) is a protein in the body that is produced by the liver and helps protect the lungs from damage. In AAT deficiency, the liver does not produce enough of this protein.
AAT deficiency is an inherited condition, and it is the only known genetic risk factor for COPD. It accounts for less than 1% of all cases of COPD in the United States. Severe AAT deficiency leads to emphysema at an early age; in nonsmokers, the average age of onset of emphysema is 53 years, and in smokers, it is 40 years.
Medically Reviewed by a Doctor on 6/7/2013
Must Read Articles Related to Chronic Obstructive Pulmonary Disease (COPD)
Patient Comments & Reviews
The eMedicineHealth doctors ask about Chronic Obstructive Pulmonary Disease (COPD):
COPD - Diagnosis
How was your COPD diagnosed?
COPD - Medications
What medications have been effective in treating your COPD?
COPD - Home Remedies
What home remedies have been effective in treating your COPD?
COPD - Causes
What caused your COPD?
COPD - Treatment
What was the treatment for your COPD?
COPD - Prognosis
What is your COPD prognosis?
COPD - Experience
Please describe your experience with COPD.
Chronic Obstructive Pulmonary Disease - Symptoms
The symptoms of chronic obstructive pulmonary disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease?