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May 21, 2013

clomipramine - oral, Anafranil Glossary of Terms

The following are health and medical definitions of terms that appear in the clomipramine - oral, Anafranil article.

Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal pain: Pain in the belly. Abdominal pain can be acute or chronic. It may reflect a major problem with one of the organs in the abdomen, such as appendicitis or a perforated intestine, or it may result from a fairly minor problem, such as excess buildup of intestinal gas.

Allergic reaction: The hypersensitive response of the immune system of an allergic individual to a substance.
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Alprazolam: A benzodiazepine sedative that causes dose-related depression of the central nervous system. Alprazolam is useful in treating anxiety, panic attacks, insomnia, and muscle spasms. The brand name is Xanax. A generic version is available.

Amitriptyline: An antidepressant medication. In some patients with depression, abnormal levels of brain chemicals called neurotransmitters may relate to the depression. Amitriptyline elevates mood by raising the level of neurotransmitters in brain tissue. Amitriptyline is also a sedative that is useful for depressed patients with insomnia, restlessness, and nervousness. It is sometimes used to treat fibromyalgia and symptoms related to chronic pain. Brand names are Elavil and Endep. A generic version is available.

Amphetamine: A drug that has a stimulant effect on the central nervous system that can be both physically and psychologically addictive when overused. Amphetamine has been much abused recreationally. The street term 'speed' refers to stimulant drugs such as amphetamine.

Anti-: Prefix generally meaning "against, opposite or opposing, and contrary." In medicine, anti- often connotes "counteracting or effective against" as in antibacterial, anti-infective, and antiviral. Sometimes medical terms containing anti- take on new meanings as has occurred with antibiotic and antibody. As a prefix, anti- may be shortened to ant- as in antacid. "Anti" is the Greek word for "against."

Antidepressant: Anything, and especially a drug, used to prevent or treat depression.
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Antidepressants: Anything, and especially a drug, used to prevent or treat depression.
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Antihistamines: Drugs that combat the histamine released during an allergic reaction by blocking the action of the histamine on the tissue. Antihistamines do not stop the formation of histamine nor do they stop the conflict between the IgE and antigen. Therefore, antihistamines do not stop the allergic reaction but protect tissues from some of its effects. Antihistamines frequently cause mouth dryness and sleepiness. Newer "non sedating" antihistamines are generally thought to be somewhat less effective. Antihistamine side effects that very occasionally occur include urine retention in males and fast heart rate.

Anxiety: A feeling of apprehension and fear, characterized by physical symptoms such as palpitations, sweating, and feelings of stress.

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
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Aspirin: Once the Bayer trademark for acetylsalicylic acid, now the common name for this anti-inflammatory pain reliever.

Asthma: A common lung disorder in which inflammation causes the bronchi to swell and narrow the airways, creating breathing difficulties that may range from mild to life-threatening. Symptoms include shortness of breath, cough, wheezing, and chest tightness. The diagnosis of asthma is based on evidence of wheezing and is confirmed with breathing tests. Many allergens and irritants can precipitate attacks of asthma. Avoidance of precipitating factors can be helpful. Treatment may include lifestyle changes, activity reduction, allergy shots, and medications to prevent or reverse the bronchospasm.

Atropine: A drug, made from the belladonna plant, that is administered via injection, eye drops, or in oral form to relax muscles by inhibiting nerve responses.

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Belladonna: An herbaceous plant bearing the scientific name Atropa belladonna or Atropa bella-donna, also known as deadly nightshade. The leaves and berries of the plant are highly toxic and can lead to hallucinations and delirium when ingested. Eating just a few berries from the plant can be fatal in children. The belladonna plant has a long history of use by humans for medicines, cosmetics, and poisons. It is native to Europe, Western Asia, and North Africa but has been naturalized in parts of North America.
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Bipolar disorder: A mood disorder sometimes called manic-depressive illness or manic-depression that characteristically involves cycles of depression and elation or mania. Sometimes the mood switches from high to low and back again are dramatic and rapid, but more often they are gradual and slow, and intervals of normal mood may occur between the high (manic) and low (depressive) phases of the condition. The symptoms of both the depressive and manic cycles may be severe and often lead to impaired functioning.
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Blurred vision: Lack of sharpness of vision with, as a result, the inability to see fine detail. Blurred vision can occur when a person who wears corrective lens is without them. Blurred vision can also be an important clue to eye disease.

Brain: The portion of the central nervous system that is located within the skull. It functions as a primary receiver, organizer, and distributor of information for the body. It has a right half and a left half, each of which is called a hemisphere.

Breast milk: Milk from the breast. Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system. Human milk also contains immunologic agents and other compounds that act against viruses, bacteria, and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction and then exhaled due to muscle relaxation.

Bronchitis: Inflammation and swelling of the bronchi. Bronchitis can be acute or chronic.

Bulimia: Also called bulimia nervosa. An eating disorder characterized by episodes of secretive excessive eating (binge-eating) followed by inappropriate methods of weight control, such as self-induced vomiting (purging), abuse of laxatives and diuretics, or excessive exercise. The insatiable appetite of bulimia is often interrupted by periods of anorexia.
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Cardiac: Having to do with the heart.

Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart, and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum. Also known as thorax.

Chest pain: Pain in the chest that can be a result of many things, including angina, heart attack (coronary occlusion), and other important diseases. Chest pain is a warning to seek medical attention, so one should try not to ignore chest pain and 'work through it.'

Chronic: In medicine, lasting a long time. A chronic condition is one that lasts 3 months or more. Chronic diseases are in contrast to those that are acute (abrupt, sharp, and brief) or subacute (within the interval between acute and chronic).

Chronic bronchitis: Inflammation and swelling of the lining of the airways, leading to narrowing and obstruction generally resulting in daily cough. The inflammation stimulates production of mucus, which can cause further blockage of the airways. Obstruction of the airways, especially with mucus, increases the likelihood of bacterial lung infection. Chronic bronchitis is common in persons who have smoked for extended periods.

Constipation: Infrequent and frequently incomplete bowel movements. Constipation is the opposite of diarrhea and is commonly caused by irritable bowel syndrome (IBS), diverticulosis, and medications. Paradoxically, constipation can also be caused by overuse of laxatives. Colon cancer can also narrow the colon and thereby cause constipation. A high-fiber diet can frequently relieve constipation. If the diet is not helpful, medical evaluation is warranted.

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Coronary artery disease: Impedance or blockage of one or more arteries that supply blood to the heart, usually due to atherosclerosis (hardening of the arteries). Abbreviated CAD. A major cause of illness and death, CAD begins when hard cholesterol substances (plaques) are deposited within a coronary artery. The plaques in the coronary arteries can lead to the formation of tiny clots that can obstruct the flow of blood to the heart muscle, producing symptoms and signs of CAD, including chest pain (angina pectoris), heart attack (myocardial infarction), and sudden death. Treatment for CAD includes bypass surgery, balloon angioplasty, and the use of stents.

Delirium: A sudden state of severe confusion and rapid changes in brain function, sometimes associated with hallucinations and hyperactivity, during which the patient is inaccessible to normal contact. Delirium can be due to a number of conditions, including infection, drug toxicity or withdrawal, seizures, brain tumor, poisoning, head injury, and metabolic disturbances.

Depression: An illness that involves the body, mood, and thoughts and that affects the way a person eats, sleeps, feels about himself or herself, and thinks about things. Depression is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with depression cannot merely 'pull themselves together' and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression. The signs and symptoms of depression include loss of interest in activities that were once interesting or enjoyable, including sex; loss of appetite, with weight loss, or overeating, with weight gain; loss of emotional expression (flat affect); a persistently sad, anxious, or empty mood; feelings of hopelessness, pessimism, guilt, worthlessness, or helplessness; social withdrawal; unusual fatigue, low energy level, a feeling of being slowed down; sleep disturbance and insomnia, early-morning awakening or oversleeping; trouble concentrating, remembering, or making decisions; unusual restlessness or irritability; persistent physical problems such as headaches, digestive disorders, or chronic pain that do not respond to treatment, and thoughts of death or suicide or suicide attempts. The principal types of depression are called major depression, dysthymia, and bipolar disease (manic-depressive disease).

Dextromethorphan: An oral cough suppressant available in the US without a prescription but which is sometimes abused as a recreational drug. Dextromethorphan (DXM) is chemically related to codeine and acts on the brain to suppress cough, but it does not have the pain relieving and addictive properties of codeine. DXM is an ingredient in more than 125 nonprescription cough and cold medications, including forms of Robitussin, Coricidin and Vicks.
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Diarrhea: A common condition that involves unusually frequent and liquid bowel movements. The opposite of constipation. There are many infectious and noninfectious causes of diarrhea. Persistent diarrhea is both uncomfortable and dangerous to the health because it can indicate an underlying infection and may mean that the body is not able to absorb some nutrients due to a problem in the bowels. Treatment includes drinking plenty of fluids to prevent dehydration and taking over-the-counter remedies. People with diarrhea that persists for more than a couple days, particularly small children or elderly people, should seek medical attention.

Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Drain: A device for removing fluid from a cavity or wound. A drain is typically a tube or wick. As a verb, to allow fluid to be released from a confined area.

Dry mouth: The condition of not having enough saliva to keep the mouth wet. This is due to inadequate function of the salivary glands. Everyone has dry mouth once in a while when they are nervous, upset or under stress. But if someone has a dry mouth most all of the time, it can be uncomfortable and lead to serious health problems.
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Electroconvulsive therapy: The use of controlled, measured doses of electric shock to induce convulsions. Convulsions so induced can sometimes treat clinical depression that is unresponsive to medication. Abbreviated ECT.

Enzymes: Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

Epinephrine: A substance produced by the medulla (inside) of the adrenal gland. The name epinephrine was coined in 1898 by the American pharmacologist and physiologic chemist (biochemist) John Jacob Abel who isolated it from the adrenal gland which is located above (epi-) the kidney ("nephros" in Greek). (Abel also crystallized insulin). Technically speaking, epinephrine is a sympathomimetic catecholamine. It causes quickening of the heart beat, strengthens the force of the heart's contraction, opens up the airways (bronchioles) in the lungs and has numerous other effects. The secretion of epinephrine by the adrenal is part of the fight-or-flight reaction. Adrenaline is a synonym of epinephrine and is the official name in the British Pharmacopoeia.

Erythromycin: Erythromycin is a common antibiotic for treating bacterial infection. Sold under many brand names, including EES, Erycin and Erythromia.

Esophagus: The tube that connects the pharynx (throat) with the stomach. The esophagus lies between the trachea (windpipe) and the spine. It passes down the neck, pierces the diaphragm just to the left of the midline, and joins the cardiac (upper) end of the stomach. In an adult, the esophagus is about 25 centimeters (10 inches) long. When a person swallows, the muscular walls of the esophagus contract to push food down into the stomach. Glands in the lining of the esophagus produce mucus, which keeps the passageway moist and facilitates swallowing. Also known as the gullet or swallowing tube. From the Greek oisophagos, from oisein meaning to bear or carry + phagein, to eat.

Family history: The family structure and relationships within the family, including information about diseases in family members.
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FDA: Food and Drug Administration.

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Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.).
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Fiber: The parts of fruits and vegetables that cannot be digested. Fiber is of vital importance to digestion; it helps the body move food through the digestive tract, reduces serum cholesterol, and contributes to disease protection. Also known as bulk and roughage.

Flush: (1) A redness of the skin, typically over the cheeks or neck. A flush is usually temporary and brought on by excitement, exercise, fever, or embarrassment. Flushing is an involuntary (uncontrollable) response of the nervous system leading to widening of the capillaries of the involved skin. Also referred to as a blush (or, as a verb, to blush). Flushing may also be caused by medications or other substances that cause widening of the capillaries, such as niacin. (2) Flush also means to wash out a wound or body area.

Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Glaucoma: A common eye condition in which the fluid pressure inside the eyes rises because of slowed fluid drainage from the eye. If untreated, it may damage the optic nerve and other parts of the eye, causing the loss of vision or even blindness.
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Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. The heart is positioned in the chest behind the sternum (breastbone); in front of the trachea, esophagus, and aorta; and above the diaphragm. A normal heart is about the size of a closed fist and weighs about 298 grams or 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest, with the balance in the right side of the chest. The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an anatomically separate left atrium and ventricle. The blood flows from the systemic veins into the right atrium, thence to the right ventricle, from which it is pumped to the lungs and then returned into the left atrium, thence to the left ventricle, from which it is driven into the systemic arteries. The heart is thus functionally composed of two hearts: the right heart and the left heart. The right heart consists of the right atrium, which receives deoxygenated blood from the body, and the right ventricle, which pumps the deoxygenated blood to the lungs under low pressure; and the left heart, which consists of the left atrium, which receives oxygenated blood from the lung, and the left ventricle, which pumps the oxygenated blood out to the body under high pressure.

Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
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Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling (edema), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart.
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Heart rate: The number of heartbeats per unit of time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast (tachycardia) or too slow (bradycardia). The pulse is a bulge of an artery from waves of blood that course through the blood vessels each time the heart beats. The pulse is often taken at the wrist to estimate the heart rate.

Heartburn: An uncomfortable feeling of burning and warmth occurring in waves rising up behind the breastbone (sternum) toward the neck. It is usually due to gastroesophageal reflux disease (GERD), the rise of stomach acid back up into the esophagus. Heartburn has nothing whatsoever to do with the heart. It is a popular nonmedical term. It is medically called pyrosis.

Hernia: A general term referring to a protrusion of a tissue through the wall of the cavity in which it is normally contained. Also known as rupture.

Hiatal: Pertaining to an hiatus, an opening.
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Hiatal hernia: An anatomical abnormality in which part of the stomach protrudes up through the diaphragm into the chest.
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High blood pressure: A repeatedly elevated blood pressure exceeding 140 over 90 mmHg. Chronic high blood pressure can stealthily cause blood vessel changes in the back of the eye (retina), abnormal thickening of the heart muscle, kidney failure, and brain damage. No specific cause for high blood pressure is found in 95 percent of patients. Treatment for high blood pressure involves dietary changes, regular aerobic exercise, and medication. There are many types of medications used to treat high blood pressure including diuretics, beta-blockers, blood vessel dilators, and others. Also known as hypertension.

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HIV: Acronym for the Human Immunodeficiency Virus, the cause of AIDS (acquired immunodeficiency syndrome). HIV has also been called the human lymphotropic virus type III, the lymphadenopathy-associated virus and the lymphadenopathy virus. No matter what name is applied, it is a retrovirus. (A retrovirus has an RNA genome and a reverse transcriptase enzyme. Using the reverse transcriptase, the virus uses its RNA as a template for making complementary DNA which can integrate into the DNA of the host organism).
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Ibuprofen: A nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, swelling, and fever. Common brand names of ibuprofen include Advil, Motrin, and Nuprin.

Ileus: Obstruction of the intestine due to its being paralyzed. The paralysis does not need to be complete to cause ileus, but the intestine must be so inactive that food cannot pass through it, which leads to blockage of the intestine. Ileus commonly follows some types of surgery. It can also result from certain drugs, injuries, and illnesses. Regardless of the cause, ileus causes constipation and bloating. When one listens to the abdomen with a stethoscope, no bowel sounds are heard because the bowel is inactive. Also known as paralytic ileus.

Infant: A young baby, from birth to 12 months of age.

Infection: The invasion and multiplication of microorganisms such as bacteria, viruses, and parasites that are not normally present within the body. An infection may cause no symptoms and be subclinical, or it may cause symptoms and be clinically apparent. An infection may remain localized, or it may spread through the blood or lymphatic vessels to become systemic (bodywide). Microorganisms that live naturally in the body are not considered infections. For example, bacteria that normally live within the mouth and intestine are not infections.

Intraocular: In the eye. For example, intraocular pressure is the pressure within the eye.

Intraocular pressure: The pressure created by the continual renewal of fluids within the eye. The intraocular pressure is increased in glaucoma.
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Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin and makes the person want to scratch the affected area. Itching is medically known as pruritis; something that is itchy is pruritic.

Kidney: One of a pair of organs located in the right and left side of the abdomen. The kidneys remove waste products from the blood and produce urine. As blood flows through the kidneys, the kidneys filter waste products, chemicals, and unneeded water from the blood. Urine collects in the middle of each kidney, in an area called the renal pelvis. It then drains from the kidney through a long tube, the ureter, to the bladder, where it is stored until elimination. The kidneys also make substances that help control blood pressure and regulate the formation of red blood cells.

Laboratory: A place for doing tests and research procedures, and for preparing chemicals and some medications. Also known as lab.

Laxative: Something that promotes emptying of the bowels. Laxatives are used to combat constipation. They are sometimes overused, producing diarrhea. Laxatives include milk of magnesia and many others.

Lightheadedness: A feeling you are "going to faint." Lightheadedness is medically distinct from dizziness, unsteadiness, and vertigo. See: Dizziness, Unsteadiness, and Vertigo.

Lithium: A naturally occurring salt that, in purified form, is used to treat certain psychiatric disorders, especially bipolar disease The therapeutic level of lithium'the amount needed to treat bipolar disorders'is perilously close to the level that can cause toxicity, so monitoring of blood levels is required. Symptoms of lithium toxicity include diarrhea, vomiting, blurred vision, loss of coordination, and loss of motor control. Treatment of lithium toxicity involves immediately reducing or discontinuing lithium use under medical supervision.

Liver: The largest solid organ in the body, situated in the upper part of the abdomen on the right side. The liver has a multitude of important and complex functions, including to manufacture proteins, including albumin (to help maintain the volume of blood) and blood clotting factors; to synthesize, store, and process fats, including fatty acids (used for energy) and cholesterol; to metabolize and store carbohydrates (used as the source for the sugar in blood); to form and secrete bile that contains bile acids to aid in the intestinal absorption of fats and the fat-soluble vitamins A, D, E, and K; to eliminate, by metabolizing or secreting, the potentially harmful biochemical products produced by the body, such as bilirubin, from the breakdown of old red blood cells and ammonia from the breakdown of proteins; and to detoxify, by metabolizing and/or secreting, drugs, alcohol, and environmental toxins.

Macrolide: One in a class of antibiotics that includes Biaxin, Clarithromycin, Ery-Tab, and Erythromycin.
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Magnesium: A mineral involved in many processes in the body including nerve signaling, the building of healthy bones, and normal muscle contraction. About 350 enzymes are known to depend on magnesium.
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Malignant: 1. Tending to be severe and become progressively worse, as in malignant hypertension. 2. In regard to a tumor, having the properties of a malignancy that can invade and destroy nearby tissue and that may spread (metastasize) to other parts of the body.
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Medical history: 1. In clinical medicine, the patient's past and present which may contain relevant information bearing on their health past, present, and future. The medical history, being an account of all medical events and problems a person has experienced is an important tool in the management of the patient.
2. The history of medicine.

MedicAlert: A nonprofit emergency medical information service, known for its MedicAlert jewelry, particularly the bracelet, and its 24-hour emergency response center.
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Memory: 1. The ability to recover information about past events or knowledge. 2. The process of recovering information about past events or knowledge. 3. Cognitive reconstruction. The brain engages in a remarkable reshuffling process in an attempt to extract what is general and what is particular about each passing moment.
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Menstrual: Pertaining to menstruation (the menses), as in last menstrual period, menstrual cramps, menstrual cycle, and premenstrual syndrome. From the Latin menstrualis, from mensis meaning month.

Motion sickness: A disorder of the sense of balance and equilibrium and, hence, the sense of spatial orientation that is caused by repeated motion such as from the swell of the sea, the movement of a car, or the motion of a plane in turbulent air. Motion sickness is due to irritation of a portion of the inner ear called the labyrinth. The symptoms of motion sickness include nausea, vomiting, and vertigo. Other common signs of motion sickness are sweating and a general feeling of discomfort and not feeling well (malaise). Symptoms usually stop when the motion that causes it ceases. However, some people suffer symptoms for even a few days after the trip is over.

Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Narcotic: 1. A drug that causes insensibility or stupor. A narcotic induces narcosis, from the Greek "narke" for "numbness or torpor."
2. A drug such as marijuana which is subject to regulatory restrictions comparable to those for addictive narcotics.

Nasal: Having to do with the nose.

Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.

Neuroblastoma: A childhood form of cancer that arises in the adrenal gland or in tissue in the nervous system that is related to the adrenal gland. Neuroblastoma is the most common solid tumor outside the brain in infants and children. It is often present at birth but may not be detected until later in infancy or childhood. The most common symptoms are the result of pressure by the tumor or bone pain from metastases. Protruding eyes and dark circles around the eyes are common and are caused by cancer that has spread to the area behind the eye. Neuroblastomas may compress the spinal cord, causing paralysis. Up to 70 percent of all children with neuroblastoma have metastases by the time the disease is diagnosed. Treatment may involve surgery, chemotherapy, radiation therapy, and stem cell transplant. It can be cured when diagnosed at an early stage. Screening infants for neuroblastoma is not warranted because it does not decrease the morbidity (illness) or mortality rate.

Neuroleptic: A term that refers to the effects of antipsychotic drugs on a patient, especially on his or her cognition and behavior.
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Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

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OCD: 1. Obsessive-compulsive disorder; 2. Osteochondritis dissecans.

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Panic: A sudden strong feeling of fear that prevents reasonable thought or action. The word comes from the name of the Greek woodland god Pan, who was a frightening figure'part human, part goat'and whose pet caprice was to terrify people who ventured into rural areas.

Pharmacist: A professional who fills prescriptions and, in the case of a compounding pharmacist, makes them. Pharmacists are very familiar with medication ingredients, interactions, and cautions.

Poison: Any substance that can cause severe organ damage or death if ingested, breathed in, or absorbed through the skin. Many substances that normally cause no problems, including water and most vitamins, can be poisonous if taken in excessive quantity. Poison treatment depends on the 'substance.

Poison control center: A special information center set up to inform people about how to respond to potential poisoning. These centers maintain databases of poisons and appropriate emergency treatment. Local poison control centers should be listed with other community-service numbers in the front of the telephone book, and they can also be reached immediately through any telephone operator.

Potassium: The major positive ion (cation) found inside cells. The chemical notation for potassium is K+. The proper level of potassium is essential for normal cell function. An abnormal increase in potassium (hyperkalemia) or decrease in potassium (hypokalemia) can profoundly affect the nervous system and heart, and when extreme, can be fatal. The normal blood potassium level is 3.5'5.0 milliEquivalents/liter (mEq/L), or 3.5 international units.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Prostate: A gland within the male reproductive system that is located just below the bladder. Chestnut shaped, the prostate surrounds the beginning of the urethra, the canal that empties the bladder.
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Protease: An enzyme that can split a protein into the peptides from which it was originally created.

Psychiatric: Pertaining to or within the purview of psychiatry, the medical specialty concerned with the prevention, diagnosis, and treatment of mental illness.
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Purpura: Hemorrhage (bleeding) into the surface of the skin. The area of skin with purpura is greater than 3 millimeters in diameter. The appearance of an individual area of purpura varies with the duration of the lesions. Early purpura is red and becomes darker, then purple, and brown-yellow as it fades.

Rash: Breaking out (eruption) of the skin. A rash can be caused by an underlying medical condition, hormonal cycles, allergies, or contact with irritating substances. Treatment depends on the underlying cause of the rash. Medically, a rash is referred to as an exanthem.

Ringing in the ears: Medically called tinnitus, can be due to many causes including ear infections, fluid in the ears, Meniere syndrome (the combination of tinnitus and deafness), some medications such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), aging, and ear trauma (such as from the noise of planes, firearms, or loud music). In rare situations, tinnitus may also be due to an aneurysm or an acoustic neuroma (a benign tumor on the acoustic nerve). Woodwind players are more likely to experience tinnitus than other orchestral players, probably because they usually sit just in front of the brass. If tinnitus persists or its cause is unknown, a hearing test (audiogram) should be done. Measures can be taken to lessen the intensity of tinnitus or to mask it.

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Saliva: a watery secretion in the mouth produced by the salivary glands that aids in the digestion of food. Saliva also serves to moisten and cleanse the mouth, including the tongue and teeth, and contains substances that can play a role in the prevention of infection. Saliva aids digestion by moistening food and contains enzymes that begin the digestion process. Also known as spit.

Schizophrenia: One of several brain diseases whose symptoms may include loss of personality (flat affect), agitation, catatonia, confusion, psychosis, unusual behavior, and social withdrawal. The illness usually begins in early adulthood. The cause of schizophrenia is not known, but there appear to be both genetic (inherited) and environmental components to the disease. Schizophrenia is not caused by abuse or poor parenting practices. Treatment involves use of neuroleptic medication and supportive interpersonal therapy. The prognosis is fairly good, with two-thirds of those diagnosed recovering significantly.

Scopolamine: A naturally occurring member of a large chemical class of compounds called alkaloids. Scopolamine was first introduced into medical usage in 1902. The name comes from that of the 18th-century Italian naturalist Giovanni Scopoli.
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Seizure: Uncontrolled electrical activity in the brain, which may produce a physical convulsion, minor physical signs, thought disturbances, or a combination of symptoms.
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Serotonin: A neurotransmitter that is involved in the transmission of nerve impulses. Serotonin can trigger the release of substances in the blood vessels of the brain that in turn cause the pain of migraine. Serotonin is also key to mood regulation; pain perception; gastrointestinal function, including perception of hunger and satiety; and other physical functions.

Sore: 1. (adjective) A popular term for painful, such as a sore throat. 2. (noun) A nondescript term for nearly any lesion of the skin or mucous membranes. He has a number of sores in his mouth.

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Sore throat: Pain in the throat. Sore throat may be caused by many different causes, including inflammation of the larynx, pharynx, or tonsils.
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Stomach: The digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine. When food enters the stomach, muscles in the stomach wall create a rippling motion (peristalsis) that mixes and mashes the food. At the same time, juices made by glands in the lining of the stomach help digest the food. After about 3 hours, the food becomes a liquid and moves into the small intestine, where digestion continues.

Stool: The solid matter that is discharged in a bowel movement.

Stroke: The sudden death of brain cells due to lack of oxygen, caused by blockage of blood flow or rupture of an artery to the brain. Sudden loss of speech, weakness, or paralysis of one side of the body can be symptoms. A suspected stroke can be confirmed by scanning the brain with special X-ray tests, such as CAT scans. The death rate and level of disability resulting from strokes can be dramatically reduced by immediate and appropriate medical care. Prevention involves minimizing risk factors, such as controlling high blood pressure and diabetes. Abbreviated CVA. Also known as cerebrovascular accident.

Suicidal: Pertaining to suicide. the taking of ones own life. As in a suicidal gesture, suicidal thought, or suicidal act. An "online lifeline for suicidal undergrads" may help prevent college students from committing suicide.

Sumatriptan: A triptan drug for the treatment of migraine. Marketed under the brand name Imitrex.

Surgery: The branch of medicine that employs operations in the treatment of disease or injury. Surgery can involve cutting, abrading, suturing, or otherwise physically changing body tissues and organs.

Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Syndrome: A combination of symptoms and signs that together represent a disease process.

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Therapy: The treatment of disease. Therapy is synonymous with treatment.

Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth, consisting anatomically of the pharynx and larynx. The throat contains the trachea and a portion of the esophagus.

Thrombocytopenia: : A low platelet count. Platelets are irregular, disc-shaped element in the blood that assists in blood clotting. thrombocytopenia can arise due to decreased production of platelets in the bone marrow or increased breakdown of platelets in the bloodstream, spleen, or liver. Thrombocytopenia is characterized by easy bruising and increased bleeding.

Thyroid: 1. The thyroid gland. Also, pertaining to the thyroid gland. 2. A preparation of the thyroid gland used to treat hypothyroidism. 3. Shaped like a shield. (The thyroid gland was so-named by Thomas Wharton in 1656 because it was shaped like an ancient Greek shield.)
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Tiredness: See: Tired.

Tricyclic antidepressants: One of a class of medications used to treat depression. The tricyclic antidepressants (TCAs) are also used for some forms of anxiety, fibromyalgia, and the control of chronic pain.
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Tryptophan: An amino acid, one of the 20 building blocks of protein. A dietary essential amino acid, tryptophan is necessary for optimal growth of children. Bacteria in the intestine break tryptophan down to compounds that largely are responsible for the unpleasant odor of feces. Symbol: Trp.

Urinary: Having to do with the function or anatomy of the kidneys, ureters, bladder, or urethra. For example, the urinary tract is the collection of organs of the body that produce, store, and discharge urine.

Urine: Liquid waste produced by the kidneys. Urine is a clear, transparent fluid that normally has an amber color. The average amount of urine excreted in 24 hours is between 5 to 8 cups or 40 and 60 ounces. Chemically, urine is mainly a watery solution of salt and substances called urea and uric acid. Normally, it contains about 960 parts water to 40 parts solid matter. Abnormally, it may contain sugar (in diabetes), albumin (a protein, as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components.

Vomit: Matter from the stomach that has come up into and may be ejected beyond the mouth, due to the act of vomiting.
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Warfarin: An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks.
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Withdrawal symptoms: Abnormal physical or psychological features that follow the abrupt discontinuation of a drug that has the capability of producing physical dependence. In example, common opiates withdrawal symptoms include sweating, goosebumps, vomiting, anxiety, insomnia, and muscle pain.

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