Club Drugs Glossary of Terms
The following are health and medical definitions of terms that appear in the Club Drugs article.
Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs. Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer). Acetate: A molecular ion derived from acetic acid. The formula of acetate is CH3COO-. Addiction: A chronic relapsing condition characterized by compulsive drug-seeking and abuse and by long-lasting chemical changes in the brain. Addiction is the same irrespective of whether the drug is alcohol, amphetamines, cocaine, heroin, marijuana, or nicotine. Every addictive substance induces pleasant states or relieves distress. Continued use of the addictive substance induces adaptive changes in the brain that lead to tolerance, physical dependence, uncontrollable craving and, all too often, relapse. Dependence is at such a point that stopping is very difficult and causes severe physical and mental reactions from withdrawal. The risk of addiction is in part inherited. Genetic factors, for example, account for about 40% of the risk of alcoholism. The genetic factors predisposing to addiction are not yet fully understood. ADHD: Attention deficit hyperactivity disorder. Adrenaline: A substance produced by the medulla (inside) of the adrenal gland, adrenaline (the official name in the British Pharmacopoeia) is synonymous with epinephrine. Technically speaking, adrenaline is a sympathomimetic catecholamine. It causes quickening of the heart beat, strengthens the force of the heart's contraction, opens up the bronchioles in the lungs and has numerous other effects. The secretion of adrenaline by the adrenal is part of the "fight-or-flight" reaction that we have in response to being frightened. Amnesia: Lack of memory. Amnesia after trauma can be antegrade or retrograde, depending upon whether the lack of memory relates to events occurring after or before the trauma. Amnesia is as compared to hypermnesia and hypomnesia. From a- + the Greek mneme, memory. Amphetamine: A drug with a stimulant effect on the central nervous system that can be both physically and psychologically addictive when overused. This drug has been much abused recreationally. The street term "speed" refers to stimulant drugs such as amphetamine. Anesthesia: Loss of feeling or awareness. A general anesthetic puts the person to sleep. A local anesthetic causes loss of feeling in a part of the body such as a tooth or an area of skin without affecting consciousness. Regional anesthesia numbs a larger part of the body such as a leg or arm, also without affecting consciousness. The term "conduction anesthesia" encompasses both local and regional anesthetic techniques. Many surgical procedures can be done with conduction anesthesia without significant pain. In many situations, such as a C-section, conduction anesthesia is safer and therefore preferable to general anesthesia. However, there are also many types of surgery in which general anesthesia is clearly appropriate. Anesthetic: A substance that causes lack of feeling or awareness. A local anesthetic causes loss of feeling in a part of the body. A general anesthetic puts the person to sleep. Anxiety: A feeling of apprehension and fear characterized by physical symptoms such as palpitations, sweating, and feelings of stress. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. These disorders fill people's lives with overwhelming anxiety and fear. Unlike the relatively mild, brief anxiety caused by a stressful event such as a business presentation or a first date, anxiety disorders are chronic, relentless, and can grow progressively worse if not treated. Arms: An appendage in anatomy and in clinical trials. See: Arm. Benzodiazepines: A class of drugs that act as tranquilizers and are commonly used in the treatment of anxiety. Benzodiazepines can cause drowsiness. Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension". Brain: That part of the central nervous system that is located within the cranium (skull). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres." Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation. Bruxism: Grinding and gnashing the teeth. Capsule: Capsule has many meanings in medicine including the following:
See the entire definition of Capsule Catecholamine: Pronounced cat·e·chol·amine. An amine derived from the amino acid tyrosine -- examples include epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine -- that act as hormones or neurotransmitters. There are a number of disorders involving catecholamines, including neuroblastoma, pheochromocytoma, chemodectina, the familial paraganglioma syndrome, dopamine-ß-hydroxalase deficiency, and tetrahydrobiopterin deficiency Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum. Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention. Chloral hydrate: A prescription sedative/hypnotic drug developed in the 19th century. The drug acts rapidly and induces sleep within 60 minutes, and is used for the short-term treatment of insomnia. Chloral hydrate can be taken orally in syrup or capsule form and is also available in the form of rectal suppositories. The medical use of chloral hydrate has declined over the years due to the development of the barbiturates and benzodiazepines. Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time. Club drug: A drug such as MDMA (Ecstasy), GHB, Rohypnol, ketamine, methamphetamine, and LSD that is used by young adults at all-night dance parties such as "raves" or "trances," dance clubs, and bars. Cocaine: The most potent stimulant of natural origin, a bitter addictive anesthetic (pain blocker) which is extracted from the leaves of the coca scrub (Erythroxylon coca) indigenous to the Andean highlands of South America. Cognitive: Pertaining to cognition, the process of knowing and, more precisely, the process of being aware, knowing, thinking, learning and judging. The study of cognition touches on the fields of psychology, linguistics, computer science, neuroscience, mathematics, ethology and philosophy. Coma: A state of deep unarousable unconsciousness. Cough: A rapid expulsion of air from the lungs typically in order to clear the lung airways of fluids, mucus, or material. Also called tussis. Cough suppressant: A drug used to control coughing, particularly with a dry, nagging, unproductive cough. Date rape: Rape of a woman by a man with whom she is acquainted. The rapist is usually the woman's "date" (escort). Dehydration: Excessive loss of body water. Diseases of the gastrointestinal tract that cause vomiting or diarrhea may, for example, lead to dehydration. There are a number of other causes of dehydration including heat exposure, prolonged vigorous exercise (e.g., in a marathon), kidney disease, and medications (diuretics). Delirium: A sudden state of severe confusion and rapid changes in brain function, sometimes associated with hallucinations and hyperactivity, in which the patient is inaccessible to normal contact. Symptoms may include inability to concentrate and disorganized thinking evidenced by rambling, irrelevant, or incoherent speech. There may be a reduced level of consciousness, sensory misperceptions and illusions, disturbances of sleep, drowsiness, disorientation to time, place, or person, and problems with memory. Depression: An illness that involves the body, mood, and thoughts, that affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. A depressive disorder is not the same as a passing blue mood. It is not a sign of personal weakness or a condition that can be wished away. People with a depressive disease cannot merely "pull themselves together" and get better. Without treatment, symptoms can last for weeks, months, or years. Appropriate treatment, however, can help most people with depression. Dextromethorphan: An oral cough suppressant available in the US without a prescription but which is sometimes abused as a recreational drug. Dextromethorphan (DXM) is chemically related to codeine and acts on the brain to suppress cough, but it does not have the pain relieving and addictive properties of codeine. DXM is an ingredient in more than 125 nonprescription cough and cold medications, including forms of Robitussin, Coricidin and Vicks. Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV. Dilation: The process of enlargement, stretching, or expansion. The word "dilatation" means the same thing. Both come from the Latin "dilatare" meaning "to enlarge or expand." Dissociation: In psychology and psychiatry, a perceived detachment of the mind from the emotional state or even from the body. Dissociation is characterized by a sense of the world as a dreamlike or unreal place and may be accompanied by poor memory of the specific events, which in severe form is known as dissociative amnesia. Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo. Dopamine: An important neurotransmitter (messenger) in the brain. Dysfunction: Difficult function or abnormal function. Ecstasy: 1. A state of rapture and trancelike elation. Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests. Euphoria: Elevated mood. Euphoria is a desirable and natural occurrence when it results from happy or exciting events. An excessive degree of euphoria that is not linked to events is characteristic of hypomania or mania, abnormal mood states associated with bipolar disorders. Fever: Although a fever technically is any body temperature above the normal of 98.6 degrees F. (37 degrees C.), in practice a person is usually not considered to have a significant fever until the temperature is above 100.4 degrees F (38 degrees C.). Forensic: Dealing with the application of scientific knowledge to legal problems and legal proceedings as, for example, in forensic anthropology, forensic dentistry, forensic experts, forensic medicine (legal medicine), forensic pathology, forensic science, etc. Frontal: In anatomy, pertaining to the forehead. As, for example, the frontal bone, frontal sinus, and frontal nerve. From the Latin "frons" meaning the forehead or brow. Gamma-OH:A European name for gamma hydroxybutyrate (GHB), a colorless and odorless drug used illicitly for "recreational" purposes and for "date rape." GBH is a central nervous system depressant. It tends therefore to increase sociability and function as something of a transient antidepressant. Gastroenteritis: Inflammation of the stomach and the intestines. Can cause nausea and vomiting and/or diarrhea. Gastroenteritis has numerous causes: including infectious organisms (viruses, bacteria, etc.), food poisoning, and stress. Gastrointestinal: Adjective referring collectively to the stomach and small and large intestines. Gastrointestinal tract: The tube that extends from the mouth to the anus in which the movement of muscles and release of hormones and enzymes digest food. The gastrointestinal tract starts with the mouth and proceeds to the esophagus, stomach, duodenum, small intestine, large intestine (colon), rectum and, finally, the anus. Also called the alimentary canal, digestive tract and, perhaps most often in conversation, the GI tract. Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising. Hallucinogenic: 1. As an adjective: Producing hallucinations. From hallucino- + -genic, a word ending meaning producing. 2. As a noun: A drug that induces hallucinations. (This is incorrect usage; the noun is hallucinogen.) Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes. Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest. Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure of the right or left or both ventricles. The signs and symptoms depend upon which side of the heart is failing. They can include shortness of breath (dyspnea), asthma due to the heart (cardiac asthma), pooling of blood (stasis) in the general body (systemic) circulation or in the liver's (portal) circulation, swelling (edema), blueness or duskiness (cyanosis), and enlargement (hypertrophy) of the heart. Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast (tachycardia) or too slow (bradycardia). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate. Herbal: 1. An adjective, referring to herbs, as in an herbal tea. Heroin: Semisynthetic drug derived from morphine. Discovered in 1874, it was introduced commercially in 1898 by the Bayer company in Germany. The name heroin was coined from the German heroisch meaning heroic, strong. Heroin is stronger (more potent) than morphine. High blood pressure: Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. Hydrocarbon: An organic compound composed exclusively of hydrogen and carbon. All hydrocarbons have a carbon backbone with atoms of hydrogen attached to that backbone. Hyperactivity: A higher than normal level of activity. An organ can be described as hyperactive if it is more active than usual. Behavior can also be hyperactive. Impulsivity: Inclined to act on impulse rather than thought. People who are overly impulsive, seem unable to curb their immediate reactions or think before they act. As a result, they may blurt out answers to questions or inappropriate comments, or run into the street without looking. Their impulsivity may make it hard for a child to wait for things they want or to take their turn in games. They may grab a toy from another child or hit when they are upset. Inhalant: 1. Generally, any breathable chemical vapor. JAMA: The Journal of the American Medical Association. JAMA began publication in 1883. It now bills itself as "the world's best-read medical journal". However one defines "best-read", JAMA clearly ranks as one of the two leading general medical journals published in the United States. (The other is the New England Journal of Medicine.) Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination. See the entire definition of Kidney Lancet: A small pointed knife; a surgical instrument with a short, wide, sharp-pointed, two-edged blade; a little knife with a small point. Lancets are used today to prick the skin (a finger, foot, ear lobe, etc.) to obtain a small quantity of capillary blood for testing. Lead poisoning: An environmental hazard capable of causing brain damage. In the US lead poisoning is formally defined as having at least 10 micrograms of lead per deciliter of blood. (The average level of lead, for people ages 1 to 70, is 2.3 micrograms.) Lethargy: 1. Abnormal drowsiness, stupor. 2. A state of indifference. Life support: 1. A therapy or device designed to preserve someone's life when an essential bodily system is not doing so. Life support may, for example, involve enteric feeding (by a tube), total parenteral nutrition, mechanical ventilation, a pacemaker, defibrillator, heart/lung machine, or dialysis. Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick. See the entire definition of Liver Low blood pressure: Any blood pressure that is below the normal expected for an individual in a given environment. Low blood pressure is also referred to as hypotension. Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung. Malnutrition: A term used to refer to any condition in which the body does not receive enough nutrients for proper function. Malnutrition may range from mild to severe and life-threatening. It can be a result of starvation, in which a person has an inadequate intake of calories, or it may be related to a deficiency of one particular nutrient (for example, vitamin C deficiency). Malnutrition can also occur because a person can not properly digest or absorb nutrients from the food they consume, as may occur with certain medical conditions. Malnutrition remains a significant global problem, especially in developing countries. Marijuana: A very common street and recreational drug that comes from the marijuana plant. Marx: See: Marx, Gertie F. MDMA: Abbreviation for 3-4 methylenedioxymethamphetamine. See: Ecstasy. Memory: 1. The ability to recover information about past events or knowledge. 2. The process of recovering information about past events or knowledge. 3. Cognitive reconstruction. The brain engages in a remarkable reshuffling process in an attempt to extract what is general and what is particular about each passing moment. Metabolic: Relating to metabolism, the whole range of biochemical processes that occur within us (or any living organism). Metabolism consists of anabolism (the buildup of substances) and catabolism (the breakdown of substances). Metabolism: The whole range of biochemical processes that occur within an organism. Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The biochemical reactions are known as metabolic pathways and involve enzymes that transform one substance into another substance, either breaking down a substance or building a new chemical substance. The term is commonly used to refer specifically to the breakdown of food and its transformation into energy. Methylenedioxymethamphetamine: 3-4 methylenedioxymethamphetamine (MDMA), best known on the street as "Ecstacy." An illicit drug, considered a recreational or party drug. It acts as both a stimulant and a hallucinogen. Ecstasy achieves its high by preventing the brain from reabsorbing the chemical serotonin, thereby prolonging its effects in the body. Morphine: A powerful narcotic agent with strong analgesic (painkilling) action and other significant effects on the central nervous system. It is dangerously addicting. Morphine is a naturally occurring member of a large chemical class of compounds called alkaloids. Motor: In medicine, having to do with the movement of a part of the body. Something that produces motion or refers to motion. For example, a motor neuron is a nerve cell that conveys an impulse to a muscle causing it to contract. The term "motor" today is also applied to a nerve that signals a gland to secrete. Motor is as opposed to sensory. MRI: Abbreviation and nickname for magnetic resonance imaging. For more information, see: Magnetic Resonance Imaging; Paul C. Lauterbur; Peter Mansfield. Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle." Muscle relaxant: Muscle relaxant is a term usually used to refer to skeletal muscle relaxants (drugs), which act on the central nervous system (CNS) to relax muscles. These drugs are often prescribed to reduce pain and soreness associated with sprains, strains, or other types of muscle injury. Some examples of commonly prescribed skeletal muscle relaxant medications include carisoprodol (Soma), cyclobenzaprine (Flexeril), and metaxalone (Skelaxin), which are taken in tablet form. Muscle relaxant drugs are only available by prescription in the U.S. Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted. Neocortex: The newer portion of the cerebral cortex that serves as the center of higher mental functions for humans. The neocortex contains some 100 billion cells, each with 1,000 to 10,000 synapses (connections), and has roughly 100 million meters of wiring, all packed into a structure the size and thickness of a formal dinner napkin. The cells in the neocortex are arranged in six layers, within which different regions permit vision, hearing, touch, the sense of balance, movement, emotional responses and every other feat of cognition. Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system. Neuron: A nerve cell that sends and receives electrical signals over long distances within the body. A neuron may send electrical output signals to muscle neurons (called motor neurons or motoneurons) and to other neurons. A neuron may receive electrical input signals from sensory cells (called sensory neurons) and from other neurons. A neuron that simply signals another neuron is called an interneuron. Neurotransmitter: A chemical that is released from a nerve cell which thereby transmits an impulse from a nerve cell to another nerve, muscle, organ, or other tissue. A neurotransmitter is a messenger of neurologic information from one cell to another. NIDA: Stands for the National Institute on Drug Abuse, one of the National Institutes of Health in the U.S., whose mission is to "lead the nation in bringing the power of science to bear on drug abuse and addiction through support and conduct of research across a broad range of disciplines and rapid and effective dissemination of results of that research to improve drug abuse and addiction prevention, treatment, and policy." Nose: The external midline projection from the face. Onset: In medicine, the first appearance of the signs or symptoms of an illness as, for example, the onset of rheumatoid arthritis. There is always an onset to a disease but never to the return to good health. The default setting is good health. Organic: 1. A chemical compound that contains carbon. Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life. Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors. Palpitations: Unpleasant sensations of irregular and/or forceful beating of the heart. In some patients with palpitations, no heart disease or abnormal heart rhythms can be found. In others, palpitations result from abnormal heart rhythms (arrhythmias). Arrhythmias refer to heartbeats that are too slow, too rapid, irregular, or too early. PCP: Pneumocystis carinii pneumonia. A parasitic infection of the lungs that is particularly common and life-threatening in immunosuppressed persons. Prophylaxis is available to prevent PCP. Pediatric: Pertaining to children. Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist. Poisoning: Taking a substance that is injurious to health or can cause death. Poisoning is still a major hazard to children, despite child-resistant (and sometimes adult-resistant) packaging and dose-limits per container. Potassium: The major positive ion (cation) found inside of cells. The chemical notation for potassium is K+. Preoperative: Before surgery. As opposed to postoperative, after surgery. Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container. Prevalence: The proportion of individuals in a population having a disease. Prevalence is a statistical concept referring to the number of cases of a disease that are present in a particular population at a given time. Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse. Psychedelic: 1. Hallucinogenic, distorting perception and awareness. Psychiatric: Pertaining to or within the purview of psychiatry, the medical specialty concerned with the prevention, diagnosis, and treatment of mental illness. Psychosis: In the general sense, a mental illness that markedly interferes with a person's capacity to meet life's everyday demands. In a specific sense, it refers to a thought disorder in which reality testing is grossly impaired. Pupil: The opening of the iris. The pupil may appear to open (dilate) and close (constrict) but it is really the iris that is the prime mover; the pupil is merely the absence of iris. The pupil determines how much light is let into the eye. Both pupils are usually of equal size. If they are not, that is termed anisocoria (from "a-", not + "iso", equal + "kore", pupil = not equal pupils). Rape: Forced sexual intercourse; sexual assault; sexual intercourse between an adult and a minor. Rape may be heterosexual (involving members of opposite sexes) or homosexual (involving members of the same sex). Rape involves insertion of an erect penis or an inanimate object into the female vagina or the male anus. Legal definitions of rape may also include forced oral sex and other sexual acts. Receptor: 1. In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are many receptors. There is a receptor for (insulin; there is a receptor for low-density lipoproteins (LDL); etc. To take an example, the receptor for substance P, a molecule that acts as a messenger for the sensation of pain, is a unique harbor on the cell surface where substance P docks. Without this receptor, substance P cannot dock and cannot deliver its message of pain. Variant forms of nuclear hormone receptors mediate processes such as cholesterol metabolism and fatty acid production. Some hormone receptors are implicated in diseases such as diabetes and certain types of cancer. A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions. Rectum: The last 6 to 8 inches of the large intestine. The rectum stores solid waste until it leaves the body through the anus. The word rectum comes from the Latin rectus meaning straight (which the human rectum is not). Recur: To occur again. To return. Any symptom (such as fatigue), any sign (such as a heart murmur), or any disease can recur. Relaxant: Something that relaxes, relieves, reduces tension. For example, a muscle relaxant is often administered during abdominal surgery to relax the diaphragm and keep it from moving during the surgery. Respiratory: Having to do with respiration, the exchange of oxygen and carbon dioxide. From the Latin re- (again) + spirare (to breathe) = to breathe again. Robo: Street name for the cough syrup Robitussin which contains dextromethorphan (DXM). Rohypnol: The trade name for flunitrazepam, which has been abused as a "date rape" drug. Rohypnol produces sedative-hypnotic effects including muscle relaxation and amnesia. It can produces physical and psychological dependence and can be lethal when mixed with alcohol and/or other depressants. It is not approved for use in the US and its importation is banned. Also known by a large number of street names including the forget me pill, the lunch money drug, Mexican valium, pingus, R-2, Reynolds, rib, roach, roach-2, roaches, roapies, robutal, roofies, rope, rope marijuana, rophies, rophy, ropies, roples, row-shay, ruffies, ruffles, and wolfies. Roofies: Street term for Rohypnol. Runny nose: Rhinorrhea is the medical term for this common problem. From the Greek words "rhinos" meaning "of the nose" and "rhoia" meaning "a flowing." Rupture: A break or tear in any organ (such as the spleen) or soft tissue (such as the achilles tendon). Rupture of the appendix is more likely among uninsured and minority children when they develop appendicitis. Saline: Relating to salt. As an adjective, "saline" means "salty, containing salt." As a noun "saline" is a salt solution, often adjusted to the normal salinity of the human body. Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device. Schizophrenia: One of several brain diseases whose symptoms that may include loss of personality (flat affect), agitation, catatonia, confusion, psychosis, unusual behavior, and withdrawal. The illness usually begins in early adulthood. Sedative: A drug that calms a patient down, easing agitation and permitting sleep. Sedatives generally work by modulating signals within the central nervous system. These sedatives can dangerously depress important signals needed to maintain heart and lung function if they are misused or accidentally combined, as in the case of combining prescription sedatives with alcohol. Most sedatives also have addictive potential. For these reasons, sedatives should be used under supervision, and only as needed. Sensation: In medicine and physiology, sensation refers to the registration of an incoming (afferent) nerve impulse in that part of the brain called the sensorium, which is capable of such perception. Therefore, the awareness of a stimulus as a result of its perception by sensory receptors. (Sensory is here synonymous with sensation.) Sensitivity: 1. In psychology, the quality of being sensitive. As, for example, sensitivity training, training in small groups to develop a sensitive awareness and understanding of oneself and of ones relationships with others. 2. In disease epidemiology, the ability of a system to detect epidemics and other changes in disease occurrence. 3. In screening for a disease, the proportion of persons with the disease who are correctly identified by a screening test. 4. In the definition of a disease, the proportion of persons with the disease who are correctly identified by defined criteria. Serotonin: A hormone, also called 5-hydroxytryptamine, in the pineal gland, blood platelets, the digestive tract, and the brain. Serotonin acts both as a chemical messenger that transmits nerve signals between nerve cells and that causes blood vessels to narrow. Sleep: The body's rest cycle. Snort: Take in a drug by inhalation. For example, snorting cocaine is inhaling cocaine powder through the nose where it is absorbed through the nasal tissues into the bloodstream. Sodium: The major positive ion (cation) in fluid outside of cells. The chemical notation for sodium is Na+. When combined with chloride, the resulting substance is table salt. Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office. Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin. Synapse: The point of connection usually between two nerve cells. Specifically, a synapse is a specialized junction at which a nerve cell (a neuron) communicates with a target cell. The neuron releases a chemical transmitter (a neurotransmitter) that diffuses across a small gap and activates specific specialized sites called receptors situated on the target cell. The target cell may be another neuron, or a specialized region of a muscle cell or a secretory cell (a cell than can make and secrete a substance). Neurons can also communicate through direct electrical connections (electrical synapses). Synthesis: Putting together different entities to make a whole which is new and different. In biochemistry, synthesis refers specifically to the process of building compounds from more elementary substances by means of one or more chemical reactions. Tension: 1) The pressure within a vessel, such as blood pressure: the pressure within the blood vessels. For example, elevated blood pressure is referred to as hypertension. 2) Stress, especially stress that is translated into clenched scalp muscles and bottled-up emotions or anxiety. This is the type of tension blamed for tension headaches. Tiredness: See: Tired. Tobacco: A South American herb, formally known as Nicotiana tabacum, whose leaves contain 2-8% nicotine and serve as the source of smoking and smokeless tobacco. Toxicity: The degree to which a substance can harm humans or animals. Toxicology: The study of the nature, effects and detection of poisons and the treatment of poisoning. Tranquilizer: In pharmacology, a drug that calms and relieves anxiety. The first tranquilizer, chlordiazepoxide hydrochloride (brand name: Librium) received FDA approval in 1960. Unsteadiness: Loss of one's equilibrium in regard to the environment, often with a feeling of almost falling, or the result of bumping into things. Urine: Liquid waste. The urine is a clear, transparent fluid. It normally has an amber color. The average amount of urine excreted in 24 hours is from 40 to 60 ounces (about 1,200 cubic centimeters). Chemically, the urine is mainly an aqueous (watery) solution of salt (sodium chloride) and substances called urea and uric acid. Normally, it contains about 960 parts of water to 40 parts of solid matter. Abnormally, it may contain sugar (in diabetes), albumen (a protein) (as in some forms of kidney disease), bile pigments (as in jaundice), or abnormal quantities of one or another of its normal components. Ventilator: A ventilator is a machine which mechanically assists patients in the exchange of oxygen and carbon dioxide (sometimes referred to as artificial respiration). Vessel: A tube in the body that carries fluids: blood vessels or lymph vessels. Vitamin K: One of two naturally occurring fat-soluble vitamins (vitamin K1 and vitamin K2) needed for the clotting of blood because of an essential role in the production of prothrombin (a clotting factor). The term vitamin A may also refer to a synthetic compound that is closely related chemically to the natural vitamins K1 and K2 and has similar biological activity. Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis). Withdrawal symptoms: Abnormal physical or psychological features that follow the abrupt discontinuation of a drug that has the capability of producing physical dependence. Common withdrawal symptoms include sweating, tremor, vomiting, anxiety, insomnia, and muscle pain.
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Substance Abuse Overview
People abuse substances such as drugs, alcohol, and tobacco for varied and complicated reasons, but it is clear that our society pays a significant cost. The toll for this abuse can be seen in our hospitals and emergency departments through direct damage to health by substance abuse and its link to physical trauma. Jails and prisons tally daily the strong connection between crime and drug dependence and abuse. Although use of some drugs such as cocaine has declined, use of other drugs such as heroin and "club drugs" has increased.
- Finding effective treatment for and prevention of substance abuse has been difficult. Through research, we now have a better understanding of the behavior. Studies have made it clear that drug education and prevention aimed at children and adolescents offers the best chance to curb abuse nationally.
- The 1996 National Household Survey on Drug Abuse estimated the number of u...
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