Cluster Headache Glossary of Medical Terms

Abortive: The word "abortive" has a number of meanings including prematurely born; fruitless or unsuccessful; imperfectly formed or developed; tending to cut short.
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Acupuncture: The practice of inserting needles into the body to reduce pain or induce anesthesia . More broadly, acupuncture is a family of procedures involving the stimulation of anatomical locations on or in the skin by a variety of techniques. There are a number of different approaches to diagnosis and treatment in American acupuncture that incorporate medical traditions from China, Japan, Korea, and other countries. The most thoroughly studied mechanism of stimulation of acupuncture points employs penetration of the skin by thin, solid, metallic needles, which are manipulated manually or by electrical stimulation.
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Amitriptyline: An antidepressant medication. In some patients with depression , abnormal levels of brain chemicals called neurotransmitters may relate to the depression. Amitriptyline elevates mood by raising the level of neurotransmitters in brain tissue. Amitriptyline is also a sedative that is useful for depressed patients with insomnia, restlessness, and nervousness. It is sometimes used to treat fibromyalgia and symptoms related to chronic pain . Brand names are Elavil and Endep. A generic version is available.
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Antidepressant: Anything, and especially a drug, used to prevent or treat depression.
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Antidepressants : Anything, and especially a drug, used to prevent or treat depression .
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Atenolol : A medication that blocks the action of a portion of the involuntary nervous system that stimulates the pace of the heartbeat. By blocking the action of these nerves, atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. Atenolol also reduces the force of heart muscle contraction, lowers blood pressure, and is helpful in treating angina . It is also used for the prevention of migraine headaches and the treatment of certain types of tremors. The brand name is Tenormin. Generic is available.
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Atypical: Not typical, not usual, not normal, abnormal. Atypical is often used to refer to the appearance of precancerous or cancerous cells.
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Aura: A premonition. There is often an aura before a migraine or a grand mal seizure. The aura, a symptom of brain malfunction, may consist of flashing lights, a gleam of light, blurred vision, an odor, the feeling of a breeze, numbness, weakness, or difficulty speaking.
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Brain: That part of the central nervous system that is located within the cranium ( skull ). The brain functions as the primary receiver, organizer and distributor of information for the body. It has two (right and left) halves called "hemispheres."
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Brain tumor : A benign or malignant growth in the brain. Primary brain tumors arise in brain tissue. Secondary brain tumors are cancers that have spread to the brain tissue (metastasized) from elsewhere in the body. Brain tumors can and do occur at any age.
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Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily. Learn more about Calcium with evidence-based information on RxList.

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Cavernous sinus: A large channel of venous blood creating a "sinus" cavity bordered by the sphenoid bone and the temporal bone of the skull. The cavernous sinus is an important structure because of its location and its contents which include the third cranial (oculomotor) nerve, the fourth cranial (trochlear) nerve, parts 1 (the ophthalmic nerve) and 2 (the maxillary nerve) of the fifth cranial (trigeminal) nerve, and the sixth cranial (abducens) nerve.
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Cluster: In epidemiology, an aggregation of cases of a disease or another health-related condition, such as a cancer or birth defect, closely grouped in time and place. The number of cases in the cluster may or may not exceed the expected number. This is determined by cluster analysis, a set of statistical methods used to analyze clusters.
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Cluster headache : A distinctive syndrome of headaches, also known as migrainous neuralgia. There are two main clinical patterns of cluster headache -- the episodic and the chronic:

• Episodic: This is the most common pattern of cluster headache. It is characterized by 1-3 short attacks of pain around the eyes per day, with these attacks clustered over a stretch of 1-2 months followed by a pain-free remission, a breathing spell. The average length of remission is a year.
• Chronic: Characterized by the absence of sustained periods of remission, chronic cluster headache may start with no past history of cluster headaches, or it may emerge several years after the patient has experienced an episodic pattern of cluster headaches.
• Pictures of Headache & Migraine Triggers - Slideshow

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Consultant: An individual to whom one refers for expert advice or services. The use of consultants is common in medicine.
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Contrast: Short for "contrast media." Contrast media are X-ray dyes used to provide contrast, for example, between blood vessels and other tissue.
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CT scan: Computerized tomography scan. Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them into pictures on a screen. CT stands for computerized tomography.
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Dehydration : Excessive loss of body water. Diseases of the gastrointestinal tract that cause vomiting or diarrhea may, for example, lead to dehydration. There are a number of other causes of dehydration including heat exposure, prolonged vigorous exercise (e.g., in a marathon), kidney disease, and medications (diuretics).
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Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests.
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Eyelid: The lid or cover of the eye, a movable fold of skin and muscle that can be closed over the eyeball or opened at will. Each eye has an upper and a lower lid. An eyelid is also called a palpebra.
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Headache : A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Hemorrhage: Bleeding or the abnormal flow of blood.
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Histamine: Substance that plays a major role in many allergic reactions. Histamine dilates blood vessels and makes the vessel walls abnormally permeable.
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Histamine cephalalgia: A distinctive syndrome of headaches, also known as cluster headache or migrainous neuralgia. The common pattern of cluster headache is termed "episodic" and is characterized by 1-3 short attacks of pain each day around the eyes, clustered over a stretch of 1-2 months, followed by a pain- free breathing period (average: a year). The other main pattern of cluster headache is termed "chronic" (and is also known as chronic migrainous neuralgia). It may come out of the blue or emerge several years after an episodic pattern. It is characterized by the absence of sustained periods of remission. The episodic and acute forms of cluster headache may transform into the other, so it is clear that they are merely different-appearing patterns of one and the same disease. On the other hand, cluster headache looks different and distinct from migraine-for example, propranolol is effective for migraine but not cluster headache while lithium benefits cluster headache syndrome but not migraine-although the mechanisms underlying cluster headache and migraine may have a degree of commonality.
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Hypothalamus: The area of the brain that controls body temperature, hunger, and thirst.
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Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
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JAMA: The Journal of the American Medical Association. JAMA began publication in 1883. It now bills itself as "the world's best-read medical journal". However one defines "best-read", JAMA clearly ranks as one of the two leading general medical journals published in the United States. (The other is the New England Journal of Medicine.)
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Jaw: The bones below the mouth (the mandible) and the bone above the mouth just above the mouth (the maxilla). The word jaw comes from the Anglo-Saxon ceowan meaning to chew.
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Joint: A joint is the area where two bones are attached for the purpose of motion of body parts. A joint is usually formed of fibrous connective tissue and cartilage. An articulation or an arthrosis is the same as a joint.
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Lumbar: Referring to the 5 lumbar vertebrae which are situated below the thoracic vertebrae and above the sacral vertebrae in the spinal column. The 5 lumbar vertebrae are represented by the symbols L1 through L5. There are correspondingly 5 lumbar nerves.
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Lumbar puncture: A lumbar puncture or "LP" is a procedure whereby spinal fluid is removed from the spinal canal for the purpose of diagnostic testing. It is particularly helpful in the diagnosis of inflammatory diseases of the central nervous system, especially infections, such as meningitis. It can also provide clues to the diagnosis of stroke , spinal cord tumor and cancer in the central nervous system.
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Malnutrition: A term used to refer to any condition in which the body does not receive enough nutrients for proper function. Malnutrition may range from mild to severe and life-threatening. It can be a result of starvation, in which a person has an inadequate intake of calories, or it may be related to a deficiency of one particular nutrient (for example, vitamin C deficiency). Malnutrition can also occur because a person can not properly digest or absorb nutrients from the food they consume, as may occur with certain medical conditions. Malnutrition remains a significant global problem, especially in developing countries.
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Migraine: Usually, periodic attacks of headaches on one or both sides of the head. These may be accompanied by nausea, vomiting, increased sensitivity of the eyes to light (photophobia), increased sensitivity to sound (phonophobia), dizziness , blurred vision, cognitive disturbances, and other symptoms. Some migraines do not include headache, and migraines may or may not be preceded by an aura.
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Migraine headache: The most common type of vascular headache involving abnormal sensitivity of arteries in the brain to various triggers resulting in rapid changes in the artery size due to spasm (constriction). Other arteries in the brain and scalp then open (dilate), and throbbing pain is perceived in the head. The tendency to migraine is inherited and appears to involve serotonin, a chemical in the brain involved in the transmission of nerve impulses that trigger the release of substances in the blood vessels that in turn cause the pain of the migraine. These nerve impulses cause the flashing lights and other sensory phenomena known as an aura that may accompany a migraine . Not all severe headaches are migraines and not all migraines are severe.
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MRI: Abbreviation and nickname for magnetic resonance imaging . For more information, see: Magnetic Resonance Imaging ; Paul C. Lauterbur ; Peter Mansfield .
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Nasal: Having to do with the nose. Nasal drops are intended for the nose, not (for example) the eyes. The word "nasal" came from the Latin "nasus" meaning the nose or snout.
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Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza , medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain , jaundice , fever, or bleeding, a physician should be consulted.
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Nerve: A bundle of fibers that uses chemical and electrical signals to transmit sensory and motor information from one body part to another. See: Nervous system .
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Neuralgia: Pain along the course of a nerve.
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Neurological: Having to do with the nerves or the nervous system.
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Neurologist: A doctor who specializes in the diagnosis and treatment of disorders of the nervous system.
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Neurology: The medical specialty concerned with the diagnosis and treatment of disorders of the nervous system -- the brain, the spinal cord, and the nerves.
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Neuromuscular: Pertaining to both nerves and muscles, as in neuromuscular blockade by an anesthetic agent, the neuromuscular junction (the meeting place of a nerve and a muscle fiber), and neuromuscular transmission (the transfer of "information" from the nerve to the muscle).

Nose: The external midline projection from the face.
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Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Pain management : The process of providing medical care that alleviates or reduces pain. Pain management is an extremely important part of health care, as patients forced to remain in severe pain often become agitated and/or depressed and have poorer treatment outcomes. Mild to moderate pain can usually be treated with analgesic medications, such as aspirin or ibuprofen . For chronic or severe pain, opiates and other narcotics are often used, sometimes in concert with analgesics; with steroids or non-steroidal anti-inflammatory drugs when the pain is related to inflammation; or with anti-depressants, which can potentiate some pain medications without raising the actual dose of the drug, and which affect the brain's perception of pain. Narcotics carry with them a potential for side effects and addiction, so patients and caregivers must weigh the level of pain against these dangers in the pain management process. The risk of addiction is not normally a concern in the care of terminal patients.
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Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.
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Pupil: The opening of the iris. The pupil may appear to open (dilate) and close (constrict) but it is really the iris that is the prime mover; the pupil is merely the absence of iris. The pupil determines how much light is let into the eye. Both pupils are usually of equal size. If they are not, that is termed anisocoria (from "a-", not + "iso", equal + "kore", pupil = not equal pupils).
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Reuptake: The reabsorption of a secreted substance by the cell that originally produced and secreted it. The process of reuptake, for example, affects serotonin.
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Rule out: A term much used in medicine, meaning to eliminate or exclude something from consideration. The ACB (albumin cobalt binding) test helps rule out a heart attack in the differential diagnosis of severe chest pain.
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Runny nose: Rhinorrhea is the medical term for this common problem. From the Greek words "rhinos" meaning "of the nose" and "rhoia" meaning "a flowing."
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Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Selective serotonin reuptake inhibitor: A selective serotonin reuptake inhibitor (SSRI) is one of the commonly prescribed drugs for treating depression .
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Sensation: In medicine and physiology , sensation refers to the registration of an incoming ( afferent ) nerve impulse in that part of the brain called the sensorium , which is capable of such perception. Therefore, the awareness of a stimulus as a result of its perception by sensory receptors. (Sensory is here synonymous with sensation.)
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Serotonin: A hormone , also called 5-hydroxytryptamine , in the pineal gland , blood platelets, the digestive tract, and the brain. Serotonin acts both as a chemical messenger that transmits nerve signals between nerve cells and that causes blood vessels to narrow.
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Sinus: 1. An air-filled cavity in a dense portion of a skull bone. The sinuses decrease the weight of the skull. The sinuses are formed in four right-left pairs. The frontal sinuses are positioned behind the forehead, while the maxillary sinuses are behind the cheeks. The sphenoid and ethmoid sinuses are deeper in the skull behind the eyes and maxillary sinuses. The sinuses are lined by mucous-secreting cells. Air enters the sinuses through small opening in bone called ostia. If an ostium is blocked, air cannot pass into the sinus and likewise mucous cannot drain out. See also: Sinusitis .
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Skull: The skull is a collection of bones which encase the brain and give form to the head and face. The bones of the skull include the following: the frontal, parietal, occipital, temporal, sphenoid, ethmoid, zygomatic, maxilla, nasal, vomer, palatine, inferior concha, and mandible.
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Sleep : The body's rest cycle.
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Sphenopalatine neuralgia: A distinctive syndrome of headaches, better known today as cluster headache. There are two main clinical patterns of cluster headache -- the episodic and the chronic:

• Episodic: This is the most common pattern of cluster headache. It is characterized by 1-3 short attacks of pain around the eyes per day, with these attacks clustered over a stretch of 1-2 months followed by a pain-free remission, a breathing spell. The average length of remission is a year.
• Chronic: Characterized by the absence of sustained periods of remission, chronic cluster headache may start with no past history of cluster headaches, or it may emerge several years after the patient has experienced an episodic pattern of cluster headaches.

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Spinal tap: Also known as a lumbar puncture or "LP", a spinal tap is a procedure whereby spinal fluid is removed from the spinal canal for the purpose of diagnostic testing. It is particularly helpful in the diagnosis of inflammatory diseases of the central nervous system, especially infections, such as meningitis. It can also provide clues to the diagnosis of stroke , spinal cord tumor and cancer in the central nervous system.
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SSRI: Abbreviation for selective serotonin reuptake inhibitors, commonly prescribed drugs for treating depression . SSRIs affect the chemicals that nerves in the brain use to send messages to one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are not taken up by other nerves are taken up by the same nerves that released them. This process is termed "reuptake." SSRIs work by inhibiting the reuptake of serotonin, an action which allows more serotonin to be available to be taken up by other nerves.
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Stroke: The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
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Subarachnoid: Literally, beneath the arachnoid, the middle of three membranes that cover the central nervous system. In practice, subarachnoid usually refers to the space between the arachnoid and the pia mater, the innermost membrane surrounding the central nervous system.
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Subarachnoid hemorrhage: Bleeding within the head into the space between two membranes that surround the brain. The bleeding is beneath the arachnoid membrane and just above the pia mater. (The arachnoid is the middle of three membranes around the brain while the pia mater is the innermost one.)
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Sumatriptan: A triptan drug for the treatment of migraine . Marketed under the brand name Imitrex .
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Syndrome: A set of signs and symptoms that tend to occur together and which reflect the presence of a particular disease or an increased chance of developing a particular disease.
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Tear: A drop of the salty secretion of the lacrimal glands which serves to moisten the conjunctiva and cornea .
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Tension: 1) The pressure within a vessel , such as blood pressure : the pressure within the blood vessels. For example, elevated blood pressure is referred to as hypertension . 2) Stress, especially stress that is translated into clenched scalp muscles and bottled-up emotions or anxiety. This is the type of tension blamed for tension headaches.
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Throat: The throat is the anterior (front) portion of the neck beginning at the back of the mouth , consisting anatomically of the pharynx and larynx . The throat contains the trachea and a portion of the esophagus .
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Tricyclic antidepressants (TCAs): One of a class of medications used to treat depression . The tricyclic antidepressants (TCAs) are also used for some forms of anxiety, fibromyalgia , and the control of chronic pain.
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Trigeminal nerve: The trigeminal nerve functions both as the chief nerve of sensation for the face and the motor nerve controlling the muscles of mastication (chewing).
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Trigeminal neuralgia: Also called tic douloureux. Inflammation of the trigeminal nerve (the fifth cranial nerve) that most commonly causes paroxysms of very intense lightning pain in the areas of the face the nerve supplies -- the lips, eye, nose, scalp, forehead, gums, cheek, and chin -- on the involved side of the face. A less common "atypical" form of the disease causes a more constant, dull, burning, or aching pain.
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Triptan: A class of drugs introduced in the 1990s for the treatment of migraine that act as agonists for 5-hydroxytryptamine ( 5-HT ) receptors. The triptans are often very effective in relieving migraine but do not prevent future attacks or lessen their frequency.
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Tumor: An abnormal mass of tissue. Tumors are a classic sign of inflammation, and can be benign or malignant (cancerous). There are dozens of different types of tumors. Their names usually reflect the kind of tissue they arise in, and may also tell you something about their shape or how they grow. For example, a medulloblastoma is a tumor that arises from embryonic cells (a blastoma) in the inner part of the brain (the medulla). Diagnosis depends on the type and location of the tumor. Tumor marker tests and imaging may be used; some tumors can be seen (for example, tumors on the exterior of the skin) or felt (palpated with the hands).
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Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
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Zolmitriptan: A triptan drug for the treatment of migraine . Marketed under the brand name Zomig .
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