Heart Disease Glossary of Terms

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A1C: A test that measures how much glucose has been sticking during the past 3-4 months to hemoglobin, the substance in the red blood cells that carries oxygen to the cells of the body. The A1C test is important in diabetes as a long-term measure of control over blood glucose. Even outside of diabetes, an elevated A1C level may be a cardiovascular risk factor.
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Abdomen: The belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal: Relating to the abdomen, the belly, that part of the body that contains all of the structures between the chest and the pelvis. The abdomen is separated anatomically from the chest by the diaphragm, the powerful muscle spanning the body cavity below the lungs.
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Abdominal pain: Pain in the belly (the abdomen). Abdominal pain can come from conditions affecting a variety of organs. The abdomen is an anatomical area that is bounded by the lower margin of the ribs above, the pelvic bone (pubic ramus) below, and the flanks on each side. Although abdominal pain can arise from the tissues of the abdominal wall that surround the abdominal cavity (the skin and abdominal wall muscles), the term abdominal pain generally is used to describe pain originating from organs within the abdominal cavity (from beneath the skin and muscles). These organs include the stomach, small intestine, colon, liver, gallbladder, and pancreas.
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Abnormal: Not normal. Deviating from the usual structure, position, condition, or behavior. In referring to a growth, abnormal may mean that it is cancerous or premalignant (likely to become cancer).

ACE inhibitors: A drug that inhibits ACE (angiotensin converting enzyme) which is important to the formation of angiotensin II. Angiotensin II causes arteries in the body to constrict and thereby raises the blood pressure. ACE inhibitors lower the blood pressure by inhibiting the formation of angiotensin II. This relaxes the arteries. Relaxing the arteries not only lowers blood pressure, but also improves the pumping efficiency of a failing heart and improves cardiac output in patients with heart failure. ACE inhibitors are therefore used for blood pressure control and congestive heart failure.
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Acid reflux: A common condition and an abnormal one in which acid in the stomach rises up into the esophagus. This occurs because the valve separating the contents of the stomach from the esophagus does not function properly. See also: GERD.

Acute: Of abrupt onset, in reference to a disease. Acute often also connotes an illness that is of short duration, rapidly progressive, and in need of urgent care.
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Acute myocardial infarction: A heart attack.
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Adenosine: A nucleoside containing adenine as its base. Adenosine acts to dilate the coronary arteries and is employed in the adenosine thallium scan of the heart.

Alcohol abuse: Use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice. For some individuals-children or pregnant women, for example-almost any amount of alcohol use may be legally considered "alcohol abuse," depending on local laws. Heavy alcohol abuse can cause physical damage and death.

Analysis: A psychology term for processes used to gain understanding of complex emotional or behavioral issues.

Angina: Chest pain due to an inadequate supply of oxygen to the heart muscle. The chest pain of angina is typically severe and crushing. There is a feeling just behind the breastbone (the sternum) of pressure and suffocation.
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Angina pectoris: Chest pain that is typically severe and crushing with a feeling just behind the breastbone (the sternum) of pressure and suffocation, due to an inadequate supply of oxygen to the heart muscle. The term "angina pectoris" comes from the Latin "angere" meaning "to choke or throttle" + "pectus" meaning "chest". Angina pectoris was first described by the English physician William Heberden (1710-1801) and may be referred to simply as angina.

Angiogram: An x-ray of blood vessels which can be seen because the patient receives an injection of dye to outline the vessels on the x-ray.

Angiography: A procedure performed to view blood vessels after injecting them with a radioopaque dye that outlines them on x-ray. This technique can be usefully used to look at arteries in many areas of the body, including the brain, neck (carotids), heart, aorta, chest, pulmonary circuit, kidneys, gastrointestinal tract, and limbs.

Angioplasty: Procedure with a balloon-tipped catheter to enlarge a narrowing in a coronary artery. Also called Percutaneous Transluminal Coronary Angioplasty (PTCA).

Anterior: The front, as opposed to the posterior. The anterior surface of the heart is toward the breast bone (the sternum).
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Anxiety: A feeling of apprehension and fear characterized by physical symptoms such as palpitations, sweating, and feelings of stress. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. These disorders fill people's lives with overwhelming anxiety and fear. Unlike the relatively mild, brief anxiety caused by a stressful event such as a business presentation or a first date, anxiety disorders are chronic, relentless, and can grow progressively worse if not treated.
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Aortic: Pertaining to the aorta, the largest artery in the body.
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Aortic dissection: A progressive tear in the aorta. The inner lining (intima) of the aorta tears and blood surges through the tear, creating a new false channel and separating (dissecting) the middle layer (media) from the outer layer of the aorta.
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Arms: An appendage in anatomy and in clinical trials. See: Arm.

Artery: A vessel that carries blood high in oxygen content away from the heart to the farthest reaches of the body. Since blood in arteries is usually full of oxygen, the hemoglobin in the red blood cells is oxygenated. The resultant form of hemoglobin (oxyhemoglobin) is what makes arterial blood look bright red.
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Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid.
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Atherectomy: A procedure for opening up an artery by removing the plaque (atheroma) produced by the build-up of cholesterol and other fatty substances in the inner lining of the artery from atherosclerosis ("hardening of the arteries"). Atherectomy is done most often in major arteries -- such as the coronary arteries within the heart muscle and the carotid and vertebral arteries leading up to the head and brain -- that have experienced the occlusive effects of atherosclerosis.
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Atherosclerosis: A process of progressive thickening and hardening of the walls of medium-sized and large arteries as a result of fat deposits on their inner lining.
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Atorvastatin: A medication that lowers the level of cholesterol in the blood. Atorvastatin is a statin drug. All statins prevent the production of cholesterol in the liver by blocking the enzyme that makes cholesterol, HMGCoA reductase. They lower total blood cholesterol as well as low-density lipoprotein (LDL) cholesterol levels. Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. Unlike the other statins, atorvastatin can also reduce the concentration of triglycerides in the blood. (High blood concentrations of triglycerides have been associated with coronary artery disease.) The brand name of atorvastin is Lipitor.

Atrium: One of the two smaller chambers of the heart. Each atrium consists of an open space with recessed walls. The plural of atrium is atria.
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Back pain: Pain felt in the low or upper back. There are many causes of back pain.
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Blood clots: Blood that has been converted from a liquid to a solid state. Also called a thrombus.
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Blood sugar: Blood glucose. See also: High blood sugar; Low blood sugar.

Brachial artery: The artery that runs from the shoulder down to the elbow.

Brachytherapy: Radiation treatment given by placing radioactive material directly in or near the target, which is often a tumor.
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Breathing: The process of respiration, during which air is inhaled into the lungs through the mouth or nose due to muscle contraction, and then exhaled due to muscle relaxation.

Bypass: An operation in which a surgeon creates a new tubular pathway for the movement of fluids and/or other substances in the body.

CABG: Coronary artery bypass graft; and Coronary artery bypass grafting.

Calcium: A mineral found mainly in the hard part of bones, where it is stored. Calcium is added to bones by cells called osteoblasts and is removed from bones by cells called osteoclasts. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting. Food sources of calcium include dairy foods, some leafy green vegetables such as broccoli and collards, canned salmon, clams, oysters, calcium-fortified foods, and tofu. According to the National Academy of Sciences, adequate intake of calcium is 1,200 milligrams a day (four glasses of milk) for men and women 51 and older, 1,000 milligrams a day for adults 19 through 50, and 1,300 milligrams a day for children 9 through 18. The upper limit for calcium intake is 2.5 grams daily.

Calorie: A unit of food energy. In nutrition terms, the word calorie is used instead of the more precise scientific term kilocalorie which represents the amount of energy required to raise the temperature of a liter of water one degree centigrade at sea level. The common usage of the word calorie of food energy is understood to refer to a kilocalorie and actually represents, therefore, 1000 true calories of energy. A calorie is also known as cal, gram calorie, or small calorie.

Cardiac: Having to do with the heart.

Cardiologist: A doctor who specializes in treating heart disorders.

Cardiovascular: The circulatory system comprising the heart and blood vessels which carries nutrients and oxygen to the tissues of the body and removes carbon dioxide and other wastes from them.
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Catheter: A thin, flexible tube. For example, a catheter placed in a vein provides a pathway for giving drugs, nutrients, fluids, or blood products. Samples of blood can also be withdrawn through the catheter.
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Chest: The area of the body located between the neck and the abdomen. The chest contains the lungs, the heart and part of the aorta. The walls of the chest are supported by the dorsal vertebrae, the ribs, and the sternum.
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Chest pain: There are many causes of chest pain. One is angina which results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion) and other important diseases such as, for example, dissection of the aorta and a pulmonary embolism. Do not try to ignore chest pain and "work (or play) though it." Chest pain is a warning to seek medical attention.

Chest X-ray: Commonly used to detect abnormalities in the lungs, but can also detect abnormalities in the heart, aorta, and the bones of the thoracic area. Metallic objects, such as jewelry are removed from the chest and neck areas for a chest x-ray to avoid interference with x-ray penetration and improve accuracy of the interpretation.

Chewing tobacco: Tobacco that is chewed, not smoked. A form of smokeless tobacco.
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Cholesterol: The most common type of steroid in the body, cholesterol has gotten something of a bad name. However, cholesterol is a critically important molecule.
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Chronic: This important term in medicine comes from the Greek chronos, time and means lasting a long time.
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Circumflex: Curved like a bow. In anatomy, circumflex describes a structure that bends around like a bow. For example, the circumflex branch of the left coronary artery.
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Clinical trial: See: Clinical trials. See also: Inconclusive clinical trial; Negative clinical trial; Non-inferior clinical trial; Positive clinical trial.

Clinical trials: Trials to evaluate the effectiveness and safety of medications or medical devices by monitoring their effects on large groups of people.
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Computed tomography: An x-ray procedure that uses the help of a computer to produce a detailed picture of a cross section of the body. Also called a CT scan or CAT scan.

Congestion: An abnormal or excessive accumulation of a body fluid. The term is used broadly in medicine. Examples include nasal congestion (excess mucus and secretions in the air passages of the nose) seen with a common cold and congestion of blood in the lower extremities seen with some types of heart failure.

Contraction: The tightening and shortening of a muscle.

Coronary angiography: The most accurate method (the "gold standard") for evaluating and defining coronary artery disease (CAD). Coronary angiography is used to identify the exact location and severity of CAD.
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Coronary arteries: The vessels that supply the heart muscle with blood rich in oxygen. They are called the coronary arteries because they encircle the heart in the manner of a crown. The word "coronary" comes from the Latin "corona" and Greek "koron" meaning crown. Like other arteries, the coronaries may be subject to arteriosclerosis (hardening of the arteries). There are a number of coronary arteries. Those most often bypassed today include the right coronary artery, the posterior descending coronary artery, the left main coronary artery, the left anterior descending coronary artery and the left circumflex coronary artery. Plaques obstructing the coronary arteries may also be treated by balloon angioplasty, stents, and other techniques.

Coronary artery disease: A major cause of illness and death, coronary artery disease (CAD) begins when hard cholesterol substances (plaques) are deposited within a coronary artery.
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Coronary bypass: A bypass of a plaque within a coronary artery using part of a vein as a graft. See: Coronary artery bypass graft.

CT scan: Computerized tomography scan. Pictures of structures within the body created by a computer that takes the data from multiple X-ray images and turns them into pictures on a screen. CT stands for computerized tomography.
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Cure: 1. To heal, to make well, to restore to good health. Cures are easy to claim and, all too often, difficult to confirm.
2. A time without recurrence of a disease so that the risk of recurrence is small, as in the 5-year cure rate for malignant melanoma.
3. Particularly in the past, a course of treatment. For example, take a cure at a spa.
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Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Diagnosis: 1 The nature of a disease; the identification of an illness. 2 A conclusion or decision reached by diagnosis. The diagnosis is rabies. 3 The identification of any problem. The diagnosis was a plugged IV.
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Dilate: To stretch or enlarge. It comes from the Latin verb "dilatare" meaning "to enlarge or expand."

Dilating: The widening and opening of the cervix caused by uterine contractions.

Dissection: The process of cutting apart or separating tissue as, for example, in the study of anatomy or in the course of a surgical procedure.

Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Dysfunction: Difficult function or abnormal function.
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ECG: Abbreviation for electrocardiogram or EKG. The K is from "kardio" (in German).

Echocardiography: Echocardiography is a diagnostic test which uses ultrasound waves to make images of the heart chambers, valves and surrounding structures. It can measure cardiac output and is a sensitive test for inflammation around the heart (pericarditis). It can also be used to detect abnormal anatomy or infections of the heart valves.

Electrocardiogram: A recording of the electrical activity of the heart. An electrocardiogram is a simple, non-invasive procedure. Electrodes are placed on the skin of the chest and connected in a specific order to a machine that, when turned on, measures electrical activity all overaround the heart. Output is usually in the form of a long scroll of paper displaying a printed graph of activity. Newer models output the data directly to a computer and screen, although a print-out may still be made.
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Emergency department: The department of a hospital responsible for the provision of medical and surgical care to patients arriving at the hospital in need of immediate care. Emergency department personnel may also respond to certain situations within the hospital such cardiac arrests.
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Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions, converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist.
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Enzymes: Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.
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Erectile dysfunction: A common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse or the inability to achieve ejaculation, or both. Impotence can vary. It can involve a total inability to achieve an erection or ejaculation, an inconsistent ability to do so, or a tendency to sustain only very brief erections. Erectile dysfunction is also called impotence,
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Essential: 1. Something that cannot be done without.
2. Required in the diet, because the body cannot make it. As in an essential amino acid or an essential fatty acid.
3. Idiopathic. As in essential hypertension. "Essential" is a hallowed term meaning "We don't know the cause."

Excimer laser: A laser that emits very concentrated light in the ultraviolet (UV) region of the spectrum.
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Family history: The family structure and relationships within the family, including information about diseases in family members.
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Fasting: going without food or drink. Patients may be advised to fast for a certain period of time prior to surgery, medical procedures, or certain blood tests.

Fats: Plural of the word "fat". See the definition of fat.

Fatty acids: Molecules that are long chains of lipid-carboxylic acid found in fats and oils and in cell membranes as a component of phospholipids and glycolipids. (Carboxylic acid is an organic acid containing the functional group -COOH.)
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Femoral: Having to do with the femur or, less often, the thigh. As in the femoral head (the head of the femur), the femoral artery, and femoral vein.

Garlic: A perennial herb of the lily family cultivated for its pungent, edible bulbs. Garlic has been used with the intention of lowering blood pressure and cholesterol.
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Groin: In anatomy, the area where the upper thigh meets the trunk. More precisely, the fold or depression marking the juncture of the lower abdomen and the inner part of the thigh.
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HDL: High density lipoprotein.
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HDL cholesterol: Lipoproteins, which are combinations of lipids (fats) and proteins, are the form in which lipids are transported in the blood. The high-density lipoproteins transport cholesterol from the tissues of the body to the liver so it can be gotten rid of (in the bile). HDL cholesterol is therefore considered the "good" cholesterol. The higher the HDL cholesterol level, the lower the risk of coronary artery disease.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
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Heart disease: Any disorder that affects the heart. Sometimes the term "heart disease" is used narrowly and incorrectly as a synonym for coronary artery disease. Heart disease is synonymous with cardiac disease but not with cardiovascular disease which is any disease of the heart or blood vessels. Among the many types of heart disease, see, for example: Angina; Arrhythmia; Congenital heart disease; Coronary artery disease (CAD); Dilated cardiomyopathy; Heart attack (myocardial infarction); Heart failure; Hypertrophic cardiomyopathy; Mitral regurgitation; Mitral valve prolapse; and Pulmonary stenosis.

Heart muscle: A type of muscle with unique features only found in the heart. The heart muscle, or cardiac muscle, is medically called the myocardium ("myo-" being the prefix denoting muscle).

Heart rate: The number of heart beats per unit time, usually per minute. The heart rate is based on the number of contractions of the ventricles (the lower chambers of the heart). The heart rate may be too fast (tachycardia) or too slow (bradycardia). The pulse is bulge of an artery from the wave of blood coursing through the blood vessel as a result of the heart beat. The pulse is often taken at the wrist to estimate the heart rate.

Heart rhythm disorders: Abnormal rhythm of the heartbeat due to irregularities in transmission of the electrical signals that normally control heart rate and rhythm. Also known as arrhythmias. With an arrhythmia, the heartbeats may be irregular or too slow (bradycardia), too rapid (tachycardia), or occur too early. When a single heartbeat occurs earlier than normal, it is called a premature contraction. An abnormal heart rhythm can be due to electrical disturbances in the upper chambers of the heart (atria), the atrioventricular (AV) node, or the lower chambers of the heart (ventricles). Examples of atrial arrhythmias include atrial fibrillation, atrial flutter, and paroxysmal atrial tachycardia. Ventricular arrhythmias include ventricular tachycardia and ventricular fibrillation.

Heartburn: An uncomfortable feeling of burning and warmth occurring in waves rising up behind the breastbone (sternum) toward the neck. It is usually due to gastroesophageal reflux disease (GERD), the rise of stomach acid back up into the esophagus. Heartburn has nothing whatsoever to do with the heart. It is a popular nonmedical term. It is medically called pyrosis.

Heredity: Genetic transmission from parent to child.

High blood pressure: Also known as hypertension, high blood pressure is, by definition, a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Hormone: A chemical substance produced in the body that controls and regulates the activity of certain cells or organs.
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Hypercholesterolemia: High blood cholesterol. This can be sporadic (occurring with no family history) or familial. Hypercholesterolemia is one form of hyperlipidemia.
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Hypertension: High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90.
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Incision: A cut. When making an incision, a surgeon is making a cut.

Infarction: The formation of an infarct, an area of tissue death due to a local lack of oxygen.
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Internal medicine: A medical specialty dedicated to the diagnosis and medical treatment of adults. A physician who specializes in internal medicine is referred to as an internist. A minimum of seven years of medical school and postgraduate training are focused on learning the prevention, diagnosis, and treatment of diseases of adults. Subspecialties of internal medicine include allergy and immunology, cardiology (heart), endocrinology (hormone disorders), hematology (blood disorders), infectious diseases, gastroenterology (diseases of the gut), nephrology (kidney diseases), oncology (cancer), pulmonology (lung disorders), and rheumatology (arthritis and musculoskeletal disorders).

Iodine: An essential element in the diet used by the thyroid gland to make thyroid hormones.
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Ischemia: Inadequate blood supply (circulation) to a local area due to blockage of the blood vessels to the area.

Jaw: The bones below the mouth (the mandible) and the bone above the mouth just above the mouth (the maxilla). The word jaw comes from the Anglo-Saxon ceowan meaning to chew.

Kidney: One of a pair of organs located in the right and left side of the abdomen which clear "poisons" from the blood, regulate acid concentration and maintain water balance in the body by excreting urine. The kidneys are part of the urinary tract. The urine then passes through connecting tubes called "ureters" into the bladder. The bladder stores the urine until it is released during urination.

Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."

Laser: A powerful beam of light that can produce intense heat when focused at close range. Lasers are used in medicine in microsurgery, cauterization, for diagnostic purposes, etc. For example, lasers are employed in microsurgery to cut tissue and remove tissue.
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Lateral: 1. In anatomy, the side of the body or a body part that is farther from the middle or center of the body. Typically, lateral refers to the outer side of the body part, but it is also used to refer to the side of a body part. For example, when referring to the knee, lateral refers to the side of the knee farthest from the opposite knee. The opposite of lateral is medial.
2. In radiology, slang for a lateral X-ray.
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LDL cholesterol: Lipoproteins which are combinations of lipids (fats) and proteins are the form in which lipids are transported in the blood. The low-density lipoproteins transport cholesterol from the liver to the tissues of the body. LDL cholesterol is therefore considered the "bad" cholesterol.

Left atrium: The upper right chamber of the heart. The left atrium receives oxygenated blood from the lungs and pumps it down into the left ventricle which delivers it to the body.

Left ventricle: The left lower chamber of the heart that receives blood from the left atrium and pumps it out under high pressure through the aorta to the body.

Leg: In popular usage, the leg extends from the top of the thigh down to the foot. However, in medical terminology, the leg refers to the portion of the lower extremity from the knee to the ankle.
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Lipid: Another word for "fat." (Please see the various meanings of Fat.) A lipid is more formally defined as a substance such as a fat, oil or wax that dissolves in alcohol but not in water. Lipids contain carbon, hydrogen and oxygen but have far less oxygen proportionally than carbohydrates.
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Lipid profile: Pattern of lipids in the blood. (A lipid profile usually includes the total cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, and the calculated low density lipoprotein (LDL) cholesterol.

Lipids: Another word for "fats." (Please see the various meanings of Fat.) Lipids can be more formally defined as substances such as a fat, oil or wax that dissolves in alcohol but not in water. Lipids contain carbon, hydrogen and oxygen but have far less oxygen proportionally than carbohydrates.
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Lipitor: See: Atorvastatin.

Lipoprotein: A complex of lipid and protein, the way lipids travel in the blood.
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Lipoproteins: Complexes of lipid and protein, the way lipids travel in the blood.
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Liver: An organ in the upper abdomen that aids in digestion and removes waste products and worn-out cells from the blood. The liver is the largest solid organ in the body. The liver weighs about three and a half pounds (1.6 kilograms). It measures about 8 inches (20 cm) horizontally (across) and 6.5 inches (17 cm) vertically (down) and is 4.5 inches (12 cm) thick.

Low blood pressure: Any blood pressure that is below the normal expected for an individual in a given environment. Low blood pressure is also referred to as hypotension.
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Lungs: The lungs are a pair of breathing organs located with the chest which remove carbon dioxide from and bring oxygen to the blood. There is a right and left lung.

Menopause: The time in a woman's life when menstrual periods permanently stop; it is also called the "change of life." Menopause is the opposite of the menarche.
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Mitral valve: A valve in the heart situated between the left atrium and the left ventricle that permits blood to flow from the left atrium into the left ventricle but not in the reverse direction.
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Mitral valve prolapse: Drooping down or abnormal bulging of the mitral valve's cusps backward into the atrium during the contraction of the heart. Mitral valve prolapse is often an asymptomatic condition but it may be marked by mitral regurgitation with symptoms (as chest pain, fatigue, dizziness, dyspnea, or palpitations) with a tendency in some cases to endocarditis or ventricular tachycardia.
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MPH: Master of Public Health (a master's degree in this field of medicine).

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Myocardial infarction: A heart attack. Abbreviated MI.
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Myocardium: The heart muscle.

National Cholesterol Education Program: NCEP. A program designed to reduce illness and death from coronary heart disease (CHD) in the US by reducing the percentage of Americans with high blood cholesterol. Through educational efforts directed at health professionals and the public, the NCEP aims to raise awareness and understanding about high blood cholesterol as a risk factor for CHD and the benefits of lowering cholesterol levels as a means of preventing CHD. NCEP was begun by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) in November 1985.

Nausea: Nausea, is the urge to vomit. It can be brought by many causes including, systemic illnesses, such as influenza, medications, pain, and inner ear disease. When nausea and/or vomiting are persistent, or when they are accompanied by other severe symptoms such as abdominal pain, jaundice, fever, or bleeding, a physician should be consulted.

NCEP: The National Cholesterol Education Program. See: National Cholesterol Education Program

NHLBI: Stands for the National Heart, Lung, and Blood Institute, one of the National Institutes of Health in the U.S. The NHLBI's mission is to "provide leadership for a national research program in diseases of the heart, blood vessels, lungs, and blood and in transfusion medicine through support of innovative basic, clinical, and population-based and health education research."

Obesity: The state of being well above one's normal weight.
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Obstruction: Blockage of a passageway. See, for example: Airway obstruction; Intestinal obstruction.

Off-pump: Not on the pump, usually meaning not on the heart-lung machine. See also: Off-pump surgery.

Omega-3 fatty acids: A class of fatty acids found in fish oils, especially from salmon and other cold-water fish, that acts to lower the levels of cholesterol and LDL (low-density lipoproteins) in the blood. (LDL cholesterol is the "bad" cholesterol.)
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Open heart surgery: Surgery in which the chest is opened and surgery is performed on the heart. The term "open" refers to the chest, not to the heart itself. The heart may or may not be opened depending on the particular type of surgery.

Operation: Although there are many meanings to the word "operation", in medicine it refers to a surgical procedure.
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Outpatient: A patient who is not an inpatient (not hospitalized) but instead is cared for elsewhere -- as in a doctor's office, clinic, or day surgery center. The term outpatient dates back at least to 1715. Outpatient care today is also called ambulatory care.

Overweight: The term "overweight" is used in two different ways. In one sense it is a way of saying imprecisely that someone is heavy. The other sense of "overweight" is more precise and designates a state between normal weight and obesity.
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Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Oxygenation: The addition of oxygen to any system, including the human body. Oxygenation may also refer to the process of treating a patient with oxygen, or of combining a medication or other substance with oxygen.
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Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia. Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
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Palpitations: Unpleasant sensations of irregular and/or forceful beating of the heart. In some patients with palpitations, no heart disease or abnormal heart rhythms can be found. In others, palpitations result from abnormal heart rhythms (arrhythmias). Arrhythmias refer to heartbeats that are too slow, too rapid, irregular, or too early.

Passive smoking: The inhaling of environmental tobacco smoke (ETS) by someone who is not smoking. See: ETS.

Percutaneous: Through the skin, as in a percutaneous biopsy.

Pharmacy: A location where prescription drugs are sold. A pharmacy is, by law, constantly supervised by a licensed pharmacist.

Plaque: 1. An semi-hardened accumulation of substances from fluids that bathe an area. Examples include dental plaque and cholesterol plaque.
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Polygenic: Pertaining to two or more genes. As opposed to monogenic.
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Primary care: The "medical home" for a patient, ideally providing continuity and integration of health care. All family physicians and most pediatricians and internists are in primary care. The aims of primary care are to provide the patient with a broad spectrum of care, both preventive and curative, over a period of time and to coordinate all of the care the patient receives.

Primary care provider: In insurance parlance, a physician chosen by or assigned to a patient, who both provides primary care and acts as a gatekeeper to control access to other medical services.

Progressive: Increasing in scope or severity. Advancing. Going forward. In medicine, a disease that is progressive is going from bad to worse.

PTCA: Percutaneous transluminal coronary angioplasty. A procedure with a balloon-tipped catheter to enlarge a narrowing in a coronary artery. Often just called angioplasty.

Radial: A word with diverse meanings in medicine and the biomedical sciences:

1. Pertaining to the radius, the smaller bone in the forearm. The radial artery is so named because of its proximity to the radius.
2. Pertaining to the radius of a circle.
3. Spreading from a central point. A radial keratotomy is an eye operation in which incisions are made in the cornea that resemble the spokes in a wheel.

Radiation: 1. Rays of energy. Gamma rays and X-rays are two of the types of energy waves often used in medicine. 2. The use of energy waves to diagnose or treat disease. See also: Irradiation.

Radioactive: Emitting energy waves due to decaying atomic nuclei. Radioactive substances are used in medicine as tracers for diagnosis, and in treatment to kill cancerous cells.

Radioactive tracer: A radioactive molecule that can be sent through the body's circulatory or urinary system, with its progress followed by a radiation-sensitive machine.

Radionuclide: An unstable form of a chemical element that radioactively decays, resulting in the emission of nuclear radiation. Also called a radioisotope.

Reflux: The term used when liquid backs up into the esophagus from the stomach.

Restenosis: Renarrowing, as in restenosis of a coronary artery after angioplasty. From the Greek "stenos" meaning narrow.

Right atrium: The right upper chamber of the heart. The right atrium receives deoxygenated blood from the body through the vena cava and pumps it into the right ventricle which then sends it to the lungs to be oxygenated.

Right ventricle: The lower right chamber of the heart that receives deoxygenated blood from the right atrium and pumps it under low pressure into the lungs via the pulmonary artery.
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Risk factor: Something that increases a person's chances of developing a disease.

Rule out: A term much used in medicine, meaning to eliminate or exclude something from consideration. The ACB (albumin cobalt binding) test helps rule out a heart attack in the differential diagnosis of severe chest pain.

Saphenous vein: The saphenous veins -- there are two, the great and the small saphenous veins - serve as the principal veins running superficially (near the surface) up the leg.
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Saturated fat: A fat that is solid at room temperature and comes chiefly from animal food products. Some examples are butter, lard, meat fat, solid shortening, palm oil, and coconut oil. These fats tend to raise the level of cholesterol in the blood.

Scaffold: 1. In genetics, the chromosome structure consisting entirely of nonhistone proteins remaining after all the DNA and histone proteins have been removed from a chromosome.
2. In genomic mapping, a series of contigs that are in the right order but not necessarily connected in one continuous stretch of sequence.

Scan: As a noun, the data or image obtained from the examination of organs or regions of the body by gathering information with a sensing device.
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Sensation: In medicine and physiology, sensation refers to the registration of an incoming (afferent) nerve impulse in that part of the brain called the sensorium, which is capable of such perception. Therefore, the awareness of a stimulus as a result of its perception by sensory receptors. (Sensory is here synonymous with sensation.)
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Serum: The clear liquid that can be separated from clotted blood. Serum differs from plasma, the liquid portion of normal unclotted blood containing the red and white cells and platelets. It is the clot that makes the difference between serum and plasma.
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Shortness of breath: Difficulty in breathing. Medically referred to as dyspnea. Shortness of breath can be caused by respiratory (breathing passages and lungs) or circulatory (heart and blood vessels) conditions. See also dyspnea.

Shoulder: A structure made up of two main bones: the scapula (shoulder blade) and the humerus (the long bone of the upper arm). The end of the scapula, called the glenoid, is a socket into which the head of the humerus fits, forming a flexible ball-and-socket joint. The scapula is an unusually shaped bone. It extends up and around the shoulder joint at the rear to create a roof called the acromion and around the shoulder joint at the front to constitute the coracoid process. The shoulder joint is cushioned by cartilage that covers the face of the glenoid socket and the head of the humerus. The joint is stabilized by a ring of fibrous cartilage around the glenoid socket that is called the labrum. Ligaments connect the bones of the shoulder and tendons join these bones to surrounding muscles. The biceps tendon attaches the biceps muscle to the shoulder and helps stabilize the joint. Four short muscles that originate on the scapula pass around the shoulder where their tendons fuse together to form the rotator cuff.

Sore: 1. (adjective) A popular term for painful. I have sore fingers from typing dictionary terms. She has a sore throat. 2. (noun) A nondescript term for nearly any lesion of the skin or mucous membranes. He has a number of sores in his mouth.

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SPECT: An acronym that stands for Single Photon Emission Computed Tomography, a nuclear medicine procedure in which a gamma camera rotates around the patient and takes pictures from many angles, which a computer then uses to form a tomographic (cross-sectional) image.
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Statins: A class of drugs that lower cholesterol.
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Stenosis: A narrowing, as in:

• aortic stenosis (narrowing of the aortic valve of the heart),
• pulmonary stenosis (narrowing of the pulmonary valve of the heart),
• pyloric stenosis (narrowing of the outlet of the stomach), and
• spinal stenosis (narrowing of the vertebral canal).

Stent: A tube designed to be inserted into a vessel or passageway to keep it open.
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Strain: 1. An injury to a tendon or muscle resulting from overuse or trauma. 2. A hereditary tendency that originated from a common ancestor. 3. To exert maximum effort. 4. To filter.

Stress: Forces from the outside world impinging on the individual. Stress is a normal part of life that can help us learn and grow. Conversely, stress can cause us significant problems.
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Stress echocardiography: A supplement to the routine exercise cardiac stress test. During stress echocardiography, the sound waves of ultrasound are used to produce images of the heart at rest and at the peak of exercise.
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Stroke: The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
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Substance: 1. Material with particular features, as a pressor substance.
2. The material that makes up an organ or structure. Also known in medicine as the substantia.
3. A psychoactive drug as, for example, in substance abuse.

Sudden cardiac arrest: A medical emergency with absent or inadequate contraction of the left ventricle of the heart that immediately causes bodywide circulatory failure. The signs and symptoms include loss of consciousness; rapid shallow breathing progressing to apnea (absence of breathing); profoundly low blood pressure (hypotension) with no pulses that can be felt over major arteries; and no heart sounds.
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Surgeon: A physician who treats disease, injury, or deformity by operative or manual methods. A medical doctor specialized in the removal of organs, masses and tumors and in doing other procedures using a knife (scalpel). The definition of a "surgeon" has begun to blur in recent years as surgeons have begun to minimize the cutting, employ new technologies that are "minimally invasive," use scopes, etc.
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Surgery: The word "surgery" has multiple meanings. It is the branch of medicine concerned with diseases and conditions which require or are amenable to operative procedures. Surgery is the work done by a surgeon. By analogy, the work of an editor wielding his pen as a scalpel is s form of surgery. A surgery in England (and some other countries) is a physician's or dentist's office.
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Sweating: The act of secreting fluid from the skin by the sweat (sudoriferous) glands. These are small tubular glands situated within and under the skin (in the subcutaneous tissue). They discharge by tiny openings in the surface of the skin.
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Symptom: Any subjective evidence of disease. Anxiety, lower back pain, and fatigue are all symptoms. They are sensations only the patient can perceive. In contrast, a sign is objective evidence of disease. A bloody nose is a sign. It is evident to the patient, doctor, nurse and other observers.

Thallium: A metallic element having the symbol Tl and the atomic number 81 and an atomic weight of about 204.
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Therapeutic: Relating to therapeutics, that part of medicine concerned specifically with the treatment of disease. The therapeutic dose of a drug is the amount needed to treat a disease.
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Therapy: The treatment of disease.
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TMR: Stands for transmyocardial laser revascularization, a procedure by which a physician uses a laser to make holes in the heart to relieve the pain of severe angina.
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Tobacco: A South American herb, formally known as Nicotiana tabacum, whose leaves contain 2-8% nicotine and serve as the source of smoking and smokeless tobacco.
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Tomography: The process for generating a tomogram, a two-dimensional image of a slice or section through a three-dimensional object. Tomography achieves this remarkable result by simply moving an x-ray source in one direction as the x-ray film is moved in the opposite direction during the exposure to sharpen structures in the focal plane, while structures in other planes appear blurred. The tomogram is the picture; the tomograph is the apparatus; and tomography is the process.
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Tongue: The tongue is a strong muscle anchored to the floor of the mouth. It is covered by the lingual membrane which has special areas to detect tastes.
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Transmyocardial laser revascularization: A procedure by which a physician uses a laser to make holes in the heart to relieve the pain of severe angina.
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Treadmill: A machine with a moving strip on which one walks without moving forward. A treadmill was originally a wide wheel turned by the weight of people climbing on steps around its edge, used in the past to provide power for machines or as a punishment in prisons.
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Triglycerides: The major form of fat stored by the body. A triglyceride consists of three molecules of fatty acid combined with a molecule of the alcohol glycerol. Triglycerides serve as the backbone of many types of lipids (fats). Triglycerides come from the food we eat as well as from being produced by the body.
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Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
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Ventricle: A chamber of an organ. For example, the four connected cavities (hollow spaces) in the central portion of the brain and the lower two chambers of the heart are called ventricles.

Ventricular: Pertaining to the ventricles, the lower chambers of the heart, as in ventricular fibrillation and ventricular septal defect.

Vessel: A tube in the body that carries fluids: blood vessels or lymph vessels.

Vitamins: The word "vitamin" was coined in 1911 by the Warsaw-born biochemist Casimir Funk (1884-1967). At the Lister Institute in London, Funk isolated a substance that prevented nerve inflammation (neuritis) in chickens raised on a diet deficient in that substance. He named the substance "vitamine" because he believed it was necessary to life and it was a chemical amine. The "e" at the end was later removed when it was recognized that vitamins need not be amines.
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Weight loss: Weight loss is a decrease in body weight resulting from either voluntary (diet, exercise) or involuntary (illness) circumstances. Most instances of weight loss arise due to the loss of body fat, but in cases of extreme or severe weight loss, protein and other substances in the body can also be depleted. Examples of involuntary weight loss include the weight loss associated with cancer, malabsorption (such as from chronic diarrheal illnesses ), and chronic inflammation (such as with rheumatoid arthritis).

X-ray: 1. High-energy radiation with waves shorter than those of visible light. X-rays possess the properties of penetrating most substances (to varying extents), of acting on a photographic film or plate (permitting radiography), and of causing a fluorescent screen to give off light (permitting fluoroscopy). In low doses X-rays are used for making images that help to diagnose disease, and in high doses to treat cancer. Formerly called a Roentgen ray. 2. An image obtained by means of X-rays.

Yogurt: A common dish made of milk curdled and fermented with a culture of Lactobacillus (the milk bacillus). The word was acquired in the 1620s from Turkey. It can be spelled myriad ways including yogurt, yoghurt, yaghourt, yooghurt, yughard, and yaourt. The most popular spellings in the Anglo-Saxon world are yogurt and yoghurt while in France one eats yaourt.