Cranberry

Are there any interactions with medications?

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Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. Cranberry might increase how long warfarin (Coumadin) is in the body, and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

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Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Cranberry might decrease how quickly the liver breaks down some medications. Taking cranberry along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking cranberry, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.

Dosing considerations for Cranberry.

The following doses have been studied in scientific research:

BY MOUTH:

• For preventing urinary tract infections (UTIs): Cranberry juice 1-10 oz per day has been used. However, the ideal dose has not yet been determined.
• For preventing UTIs in children: 15ml/kg daily as 30% cranberry concentrate has been used.
• For use as a urinary deodorizer for incontinent patients: 3-6 oz per day of cranberry juice.
• For type 2 diabetes: Six capsules (equivalent to 240 mL cranberry juice cocktail) daily for 12 weeks. Encapsulated formulations are often taken in doses of 300-400 mg twice daily.

Approximately 1500 grams of fresh fruit produces 1 liter of juice. Cranberry juice cocktail is approximately 26% to 33% pure cranberry juice, sweetened with fructose or artificial sweetener.