Current and Future Medications for Hepatitis C (cont.)
What is the dosage for DAAs?
- 800 mg is taken three times a day, and simeprevir 150 mg is taken
once daily with food, combined with ribavirin.
- Technivie is given with ribavirin for 12
weeks for genotype 4 chronic hepatitis C virus (HCV) infection without
- Each tablet contains 12.5 mg ombitasvir, 75 mg paritaprevir and 50 mg
- Two tablets are taken every morning, with ribavirin dosed by weight:
1000 mg per day for patients weighing less than 75 kg, and 1200 mg per day for
those 75 kg and over; this is divided into a twice-daily dose with food.
Viekira Pak (ombitasvir/paritaprevir/ritonavir and dasabuvir)
- Viekira is used for genotype 1a or 1b chronic hepatitis C, including people
with or without cirrhosis and no liver failure symptoms.
- Viekira Pak is
ombitasvir 12.5 mg, paritaprevir 75mg, ritonavir 50 mg in each tablet, packaged
with dasabuvir 250mg tablets.
- It is dosed as two ombitasvir, paritaprevir,
ritonavir tablets once daily (in the morning) and one dasabuvir tablet twice
daily (morning and evening), along with a meal.
- It is given with or without
ribavirin (dosed as above).
- Genotype 1a is most resistant to treatment, so
Viekira is given with ribavirin for 12 weeks if there is no cirrhosis, or 24
weeks if there is cirrhosis.
- Genotype 1b is usually treated with Viekira alone
for 12 weeks if no cirrhosis; with cirrhosis (or in some cases of prior
treatment) it must be given with ribavirin for 12 weeks.
- Viekira may also be
liver transplant recipients.
Zepatier (grazoprevir and elbasvir)
- Zepatier is elbasvir 50 mg and grazoprevir 100 mg in one tablet, and it is
given for chronic hepatitis C genotype 1 or 4 with or without cirrhosis, and
with or without certain resistance mutations.
- While Zepatier can be given to
patients who have never been treated, it offers a special treatment option to
patients who have failed treatment with PegIFN/RBV, as well as protease
- One tablet taken orally once daily with or without food, and may be
given with or without RBV as above, depending on the individual patient.
- Patients who have been treated before or have certain resistance mutations
("NS5A") are dosed differently and for longer than other patients.
- Genotypes 1a
with NS5A mutations and genotype 4 that has failed PegIFN/RBV are treated with
Zepatier and RBV for 16 weeks.
- All others are treated for 12 weeks, with
addition of RBV in those with genotype 1 who have failed PegIFN/RBV and protease
- Sovaldi is used to treat chronic hepatitis C genotype 1 or 4
with PegIFN/RBV, or genotype 2 or 3 with RBV alone.
- One 400mg tablet is taken
once orally with or without food.
- All genotypes except for three are treated for 12 weeks;
genotype 3 is treated for 24 weeks.
- Advantages of Sovaldi includes the option
to treat genotype 1 patients who are not candidates for using interferons; these
patients may take Sovaldi alone for 24 weeks.
- Sovaldi can also be given with RBV
for up to 48 weeks to patients awaiting a liver transplant, as an attempt to
prevent HCV infection of the new liver.
Harvoni (sofosbuvir and ledipasvir)
- Harvoni is a nucleotide analog inhibitor
combination of ledipasvir 90 mg/sofosbuvir 400 mg in one tablet.
- It is taken
orally once daily with or without food.
- Harvoni is used to treat chronic
hepatitis C genotypes 1, 4, 5 or 6.
- All genotypes may be treated with Harvoni
alone regardless of prior treatment and with or without cirrhosis. With the
addition of RBV, however, Harvoni extends the option of treatment to patients
with genotype 1 who have cirrhosis and liver failure (decompensated cirrhosis).
- All treatment durations are 12 weeks with the exception of genotype 1 with
- Daklinza is an NS5A inhibitor used to treat genotype 3 chronic
hepatitis C. It is given combined with Sovaldi (sofosbuvir).
- Either 30mg or 60mg
tablets are given orally once a day with sofosbuvir for 12 weeks for patients
without cirrhosis, with the exact dose depending on drug interactions with other
medications the patient may be taking.
- There is no specific duration offered for
patients with cirrhosis, but there is no specification against using this drug
in people with even severely impaired
Medically Reviewed by a Doctor on 4/21/2016
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