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Current and Future Medications for Hepatitis C (cont.)

With which drugs do DAAs interact with?

  • Many drugs are metabolized (eliminated) from the body by enzymes in the liver. DAA are metabolized by one of the more important of these enzymes in the liver (CYP3A). As a result, drugs that enhance or reduce the activity of this liver enzyme will affect blood levels.
  • Some drugs increase the activity of CYP3A and result in reduced levels of DAA and thereby reduce their effectiveness, for example, corticosteroids (for example, prednisone).
  • Other drugs decrease the activity of CYP3A and result in elevated levels of the and possibly can lead to toxicity, for example, some of the anti-fungal drugs (for example, itraconozole [Sporanox]). 
  • Some HIV medications may need to be changed while taking some of the hepatitis C DAA.
  • The list of drugs that interact with DAA is large and includes many commonly-used drugs. It is important to review all of the drugs that patients are taking to identify drugs that interact with these drugs before treatment is begun.
Medically Reviewed by a Doctor on 4/21/2016
Pharmacy Author:

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Patient Comments & Reviews

The eMedicineHealth doctors ask about Hepatitis C Medications:

Hepatitis C Medications - Experience

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Hepatitis C - Direct-Acting Agents

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Hepatitis C - Interferons

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Hepatitis C - Ribavirin

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