Current and Future Medications for Hepatitis C (cont.)
With which drugs do DAAs interact with?
- Many drugs are metabolized (eliminated) from the body by enzymes in the
liver. DAA are metabolized by one of the more important of these enzymes in the
liver (CYP3A). As a result, drugs that enhance or reduce the activity of this
liver enzyme will affect blood levels.
- Some drugs increase the activity of CYP3A
and result in reduced levels of DAA and thereby reduce their effectiveness, for
example, corticosteroids (for example,
- Other drugs decrease the activity of CYP3A and result in
elevated levels of the and possibly can lead to toxicity, for example, some of
the anti-fungal drugs (for example, itraconozole [Sporanox]).
medications may need to be changed while taking some of the hepatitis C DAA.
list of drugs that interact with DAA is large and includes many commonly-used
drugs. It is important to review all of the drugs that patients are taking to
identify drugs that interact with these drugs before treatment is begun.
Medically Reviewed by a Doctor on 4/21/2016
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