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Current and Future Medications for Hepatitis C (cont.)

Investigational drugs

Various pharmaceutical companies are conducting clinical research determine efficacy and safety use of their novel compound sin treating hepatitis C in the near future per FDA approval:

  • BI 201335 and BI 207127 (Boehringer Ingelheim Pharmaceuticals) are being developed for the treatment of chronic HCV infection. BI 201335 and BI 207127 work by preventing the virus from replicating.
  • Thymosin alpha-1 (Zadaxin, by SciClone) is a protein that enhances the body's immune system to counteract viruses. Research is being done to determine the efficacy and safety of thymosin alpha-1 in combination with peg-interferon alfa- 2a and ribavirin for the therapy of chronic hepatitis C nonresponsive to the combination of IFN and ribavirin
  • ISIS 14803 (Isis Pharmaceuticals and Elan) is a nucleoside analog that disrupts the production of viral proteins during viral cell division, thereby decreasing the ability of HCV to multiplyABT450/r and ABT 267 (Abbott Pharmaceuticals) are being studied in combination with peginterferon alpha-2a and ribavirin in patients with HCV who did not respond to treatment in a previous study of standard combination therapy
  • Other interferons are being investigated, including recombinant interferon beta-1a (Serono Lab), omega interferon (BioMedicines), and VX-497 (Vertex Pharmaceuticals).
Medical and Pharmacy Editor:

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