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May 21, 2013
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Cushing Syndrome (cont.)

Medical Author:
George P Chrousos, MD, FAAP, MACP, MACE
Coauthor:
Shehnaz Shaikh, MD
Medical Editor:
Arthur B Chausmer, MD, PhD, FACP, FACE, FACN, CNS
Medical Editor:
Mary L Windle, PharmD
Medical Editor:
George T Griffing, MD

Cushing's Syndrome Causes

  • Exogenous administration of corticosteroids
  • Endogenous (produced by the body) corticosteroid overproduction
    • Adrenal gland tumors: Overproduction of corticosteroid may be due to an adrenal tumor, which could be cancerous or noncancerous.
    • ACTH-producing pituitary tumors: Pituitary tumors produce excess ACTH, which acts on the adrenal gland to produce excess corticosteroid.
    • Some lung tumors or other tumors outside the pituitary gland may produce ACTH, which in turn stimulate the adrenal glands to produce excess corticosteroid.

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Cushing Syndrome »

Cushing syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous glucocorticoids.

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