What is Cushing's syndrome?
Cushing's syndrome is a rare hormonal problem. It happens when there is too much of the hormone cortisol in your body.
Normally, cortisol levels increase through a chain reaction of hormones:
But if your body makes too much cortisol—or if you take certain medicines that act like cortisol—you may start to have symptoms. Cushing's syndrome may cause weight gain, skin changes, and fatigue. It can lead to serious problems, such as diabetes, high blood pressure, depression, and osteoporosis. If not treated, it can also cause death.
Another name for Cushing's syndrome is hypercortisolism.
What causes Cushing's syndrome?
Cushing's syndrome may be caused by:
What are the symptoms?
Weight gain—especially around the waist—is the most common symptom.
Cortisol affects almost all body systems, so it can cause many other symptoms. These other symptoms often appear slowly over time and may include:
Sometimes alcoholism, depression, panic attacks, obesity, or other problems can cause symptoms like these. Some treatments for HIV can also cause similar symptoms. This is called pseudo-Cushing's syndrome. In these cases, symptoms tend to stop as soon as the problems are treated.
How is Cushing's syndrome diagnosed?
Your doctor will use your medical history, a physical exam, and lab tests to see if you have Cushing's syndrome. During the physical exam, he or she will look for signs of the problem. The medical history includes questions about your symptoms, what medicines you take, and—if you are a woman—whether your periods are regular.
If your doctor thinks you may have Cushing's syndrome, you will have lab tests to check your cortisol levels. These tests can measure cortisol in your blood, urine, or saliva. More tests may be needed to find the cause of high cortisol levels.
How is it treated?
Cushing's syndrome can often be cured. But it can lead to serious health problems, including death. So it's important to start treatment right away.
If steroid medicine is causing Cushing's syndrome, your doctor will help you lower your dose or gradually stop taking it. It may take a while for the symptoms to go away.
It's very dangerous to stop taking steroid medicine on your own. Your doctor will help you change your medicine or lower your dose slowly.
If a tumor is causing Cushing's syndrome, you will need surgery to remove it. If surgery doesn't work, radiation or medicines may be used.
When you have Cushing's syndrome, it's very important to control your weight and keep your bones and muscles strong. This will help prevent diabetes, bone loss, and high blood pressure. Eating healthy foods and staying active can help you do this.
It's also important to have regular checkups to look for other problems such as diabetes, high blood pressure, and osteoporosis.
Frequently Asked Questions
eMedicineHealth Medical Reference from Healthwise
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