Font Size
A
A
A

Dementia Medication Overview (cont.)

N-methyl-D-aspartate Blockers

Drugs within the class known as N-methyl-D-aspartate (NMDA) blockers include memantine (Namenda), which has been approved by the FDA for the treatment of moderate-to-severe Alzheimer disease. After NMDA blockers are started, a notable improvement in basic activities of daily living (for example, eating, grooming, dressing) is noted. This drug can be used in combination with existing AChE inhibitors. Although observed effects will be modest, these improvements significantly aid caregivers, such as nursing home personnel or family members, in their interactions with these patients.

  • How NMDA blockers work: NMDA blockers guard against overexcitement of NMDA receptors by the brain chemical glutamate. Overexcitement of NMDA receptors by abnormally high brain levels of glutamate is thought to be responsible for decreased nerve cell function and, eventually, nerve cell death. NMDA blockers may also be helpful in other neurodegenerative conditions, such as Huntington disease, AIDS-related dementia, and vascular dementia.
  • Who should not use these medications: People with allergy to NMDA blockers should not take them.
  • Use: Tablets may be swallowed with or without food.
  • Drug or food interactions: Drugs that alter urine acidity, like sodium bicarbonate or acetazolamide (Diamox), may cause memantine to accumulate in the body.
  • Side effects: Common adverse effects include dizziness, headache, and constipation.
Medically Reviewed by a Doctor on 7/23/2014
Medical Author:
Coauthor:
Medical Editor:
Medical Editor:
Medical Editor:

Must Read Articles Related to Dementia Medication Overview

Alzheimer's Disease in Individuals With Down Syndrome
Alzheimer's Disease in Down Syndrome Alzheimer's disease (AD) is the most common form of dementia (see Dementia Overview for more information). The disease is progressive, and the brain degenerates...learn more >>




Read What Your Physician is Reading on Medscape

Dementia: Overview of Pharmacotherapy »

Perhaps the most important challenge in treating dementia is identifying cases (albeit uncommon) of reversible dementia such as chronic drug intoxication, vitamin deficiencies (B-12 and folate), subdural hematoma(s), major depression (causing forgetfulness), normal pressure hydrocephalus (NPH), and hypothyroidism.

Read More on Medscape Reference »


Medical Dictionary