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Medications and Drugs

Brand Names: MigraTen, Prodrin

Generic Name: acetaminophen, caffeine, and isometheptene (Pronunciation: a SEET a MIN o fen, KAF een, EYE soe meth EP teen)

What is acetaminophen, caffeine, and isometheptene (MigraTen, Prodrin)?

Acetaminophen is a pain reliever and a fever reducer.

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction).

Isometheptene also causes narrowing of blood vessels.

The combination of acetaminophen, caffeine, and isometheptene is used to treat migraine headaches or severe tension headaches.

Acetaminophen, caffeine, and isometheptene may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen, caffeine, and isometheptene (MigraTen, Prodrin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • low fever with nausea, stomach pain, and loss of appetite;
  • dark urine, clay-colored stools; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen, caffeine, and isometheptene (MigraTen, Prodrin)?

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Do not use acetaminophen, caffeine, and isometheptene if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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