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2. Headache and Migraine Triggers Slideshow Pictures
3. Take the Migraines Quiz

What should I discuss with my healthcare provider before taking acetaminophen, caffeine, and isometheptene (MigraTen, Prodrin)?

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Do not use acetaminophen, caffeine, and isometheptene if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

You should not take this medication if you are allergic to acetaminophen (Tylenol), caffeine, or isometheptene, or if you have:

• glaucoma;
• severe kidney disease;
• severe liver disease (especially cirrhosis);
• severe or uncontrolled high blood pressure; or
• heart disease.

To make sure you can safely take acetaminophen, caffeine, and isometheptene, tell your doctor if you have any of these other conditions:

• kidney or liver disease;
• a history of alcoholism;
• high blood pressure;
• blood circulation problems; or
• if you have recently had a heart attack.

FDA pregnancy category C. It is not known whether acetaminophen, caffeine, and isometheptene will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

This medication can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take acetaminophen, caffeine, and isometheptene (MigraTen, Prodrin)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

To treat migraine headache pain:

• Take the first dose of this medication as soon as you notice headache symptoms, or after an attack has already begun.
• If your headache does not completely go away, take 1 tablet or capsule every hour until you feel relief.
• Do not take more than a total of 5 tablets or capsules in any 12-hour period to treat a migraine.
• If you still have migraine symptoms after taking a total of 5 tablets or capsules, call your doctor.

Store at room temperature away from moisture and heat.

To treat tension headache pain:

• Take the first dose of this medication as soon as you notice tension headache symptoms.
• If your headache does not completely go away, take 1 tablet or capsule every 4 hours until you feel relief.
• Do not take more than a total of 8 tablets or capsules in any 24-hour period to treat a tension headache.
• If you still have tension headache pain after taking a total of 8 tablets or capsules, call your doctor.

Acetaminophen may cause false urine glucose test results. Talk to your doctor if you have diabetes and you notice changes in glucose test results while taking acetaminophen, caffeine, and isometheptene.

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