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Medications and Drugs

Brand Names: KneeRelief

Generic Name: acetaminophen, caffeine, and magnesium salicylate (Pronunciation: ah seet oh MIN oh fen, KAF een, mag NEEZ ee um sa LIS il ate)

What is acetaminophen, caffeine, and magnesium salicylate (KneeRelief)?

Acetaminophen is a pain reliever and a fever reducer.

Caffeine is used in this product to increase the pain relieving effects of acetaminophen.

Magnesium salicylate is used to reduce pain, inflammation, and fever.

The combination of acetaminophen, caffeine, and magnesium salicylate is used to treat pain and swelling from conditions such as muscle aches, arthritis, and joint soreness.

Acetaminophen, caffeine, and magnesium salicylate may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen, caffeine, and magnesium salicylate (KneeRelief)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking this medicine and call your doctor at once if you have a serious side effect such as:

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • easy bruising or bleeding;
  • agitation, confusion, or hallucinations; or
  • seizure (convulsions).

Less serious side effects may include:

  • mild nausea, vomiting, indigestion, or upset stomach;
  • ringing in your ears; or
  • trouble sleeping (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen, caffeine, and magnesium salicylate (KneeRelief)?

Magnesium salicylate should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other pain, cold, allergy, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Stop taking this medication and call your doctor if you have a fever lasting longer than 3 days, or pain lasting longer than 10 days.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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