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What happens if I miss a dose (KneeRelief)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (KneeRelief)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms also may include ringing in your ears, headache, confusion, agitation, restless feeling, insomnia, hallucinations, low fever, loss of appetite, seizures, or coma.

What should I avoid while taking acetaminophen, caffeine, and magnesium salicylate (KneeRelief)?

Do not drink alcohol while you are taking acetaminophen, caffeine, and magnesium salicylate. Alcohol can increase your risk of liver damage or stomach bleeding while you are taking this medication.

Do not use any other pain or fever medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP"), caffeine, and magnesium salicylate are contained in many combination medicines. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains acetaminophen, APAP, caffeine, or magnesium salicylate.

Avoid taking other over-the-counter or prescription medications that contain aspirin, salicylates, or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

What other drugs will affect acetaminophen, caffeine, and magnesium salicylate (KneeRelief)?

Before using this medication, tell your doctor if you are using any of the following drugs:

• a blood thinner such as warfarin (Coumadin), heparin, enoxaparin (Lovenox), dalteparin (Fragmin), or tinzaparin (Innohep);
• choline and magnesium salicylate (Trilisate, Tricosal), or salsalate (Disalcid);
• salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others; or
• medication used to prevent blood clots, such as alteplase (Activase), dipyridamole (Persantine), ticlopidine (Ticlid), and urokinase (Abbokinase).

This list is not complete and there may be other drugs that can interact with acetaminophen, caffeine, and magnesium salicylate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen, caffeine, and magnesium salicylate.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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