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Medications and Drugs

Brand Names: Alka-Seltzer Plus Night Time Cold Liquigel, All-Nite Multi-Symptom Cold/Flu Relief, Nyquil Cold Medicine, NyQuil D, Nyquil Liquicap, Robitussin Night Cold

Generic Name: acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine (Pronunciation: a SEET a MIN o fen, DEX troe meth OR fan, dox IL a meen, SOO doe e FED rin)

What is acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine (Alka-Seltzer Plus Night Time Cold Liquigel, All-Nite Multi-Symptom Cold/Flu Relief, Nyquil Cold Medicine, NyQuil D, Nyquil Liquicap, Robitussin Night Cold)?

Acetaminophen is a pain reliever and fever reducer.

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as sneezing, runny nose, and watery eyes.

Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine is used to treat runny or stuffy nose, sinus congestion, cough, and pain or fever caused by the common cold, allergies, or the flu.

Dextromethorphan will not treat a cough that is caused by smoking.

Acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • confusion, hallucinations, unusual thoughts or behavior;
  • slow, shallow breathing;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild nausea, upset stomach, constipation;
  • warmth, tingling, or redness under your skin;
  • problems with memory or concentration, sleep problems (insomnia);
  • blurred vision, dry mouth, ringing in your ears; or
  • mild skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen, dextromethorphan, doxylamine, and pseudoephedrine?

Do not take a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

Do not take more of this medication than is recommended. An overdose of acetaminophen can cause damage to your liver.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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