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Medications and Drugs

Brand Names: Midol PMS Maximum Strength, Pamprin Multi-Symptom, Premesyn PMS

Generic Name: acetaminophen, pamabrom, and pyrilamine (Pronunciation: ah SEET a MIN o fen, PAM a brom, pir IL a meen)

What is acetaminophen, pamabrom, and pyrilamine (Midol PMS Maximum Strength, Pamprin Multi-Symptom, Premesyn PMS)?

Acetaminophen is a pain reliever and fever reducer.

Pamabrom is a diuretic (water pill).

Pyrilamine is an antihistamine that reduces the effects of the natural chemical histamine in the body.

The combination of acetaminophen, pamabrom, and pyrilamine is used to treat the symptoms of premenstrual syndrome (PMS), such as tension, bloating, water weight gain, headache, back pain, cramps, and irritability.

Acetaminophen, pamabrom, and pyrilamine may also be used for purposes not listed in this medication guide.

What are the possible side effects of acetaminophen, pamabrom, and pyrilamine (Midol PMS Maximum Strength, Pamprin Multi-Symptom, Premesyn PMS)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • chest pain, rapid pulse;
  • fast, slow, or uneven heart rate;
  • confusion, hallucinations, severe nervousness;
  • tremor, seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all; or
  • nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes).

Less serious side effects may include:

  • dizziness, drowsiness;
  • mild headache;
  • dry mouth, nose, or throat;
  • constipation, upset stomach;
  • blurred vision;
  • feeling nervous; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about acetaminophen, pamabrom, and pyrilamine (Midol PMS Maximum Strength, Pamprin Multi-Symptom, Premesyn PMS)?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day.

You should not use this medicine if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, heart disease, or a thyroid disorder.

Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of pyrilamine.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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