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Medications and Drugs

Brand Names: Limbitrol, Limbitrol DS

Generic Name: amitriptyline and chlordiazepoxide (Pronunciation: a mi TRIP ti leen and klor dye az e POX ide)

What is amitriptyline and chlordiazepoxide (Limbitrol, Limbitrol DS)?

Amitriptyline is a tricyclic (try-SYE-klik) antidepressants. Amitriptyline affects chemicals in the brain that may become unbalanced.

Chlordiazepoxide is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxide affects chemicals in the brain that may become unbalanced and cause anxiety.

The combination of amitriptyline and chlordiazepoxide is used to treat depression and anxiety.

Amitriptyline and chlordiazepoxide may also be used for purposes not listed in this medication guide.

Amitriptyline-Chlordiazepoxide 25 mg-10 mg-MYL

round, white, imprinted with 277, MYLAN

Chlordiazepoxide-Amitriptyline 5-12.5 mg-MYL

round, green, imprinted with MYLAN, 211

What are the possible side effects of amitriptyline and chlordiazepoxide (Limbitrol, Limbitrol DS)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • confusion, hallucinations, unusual thoughts or behavior;
  • feeling light-headed, fainting;
  • seizure (convulsions);
  • weak or shallow breathing;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
  • sudden numbness or weakness (especially on one side of the body), headache, confusion, problems with vision, speech, or balance.

Less serious side effects may include:

  • dry mouth, stuffy nose, blurred vision;
  • dizziness, drowsiness;
  • feeling restless or tired;
  • constipation, bloating, loss of appetite;
  • strange dreams or nightmares; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amitriptyline and chlordiazepoxide (Limbitrol, Limbitrol DS)?

You should not use this medication if you have recently had a heart attack, or if you are allergic to amitriptyline (Elavil), chlordiazepoxide (Librium), or to Valium, Xanax, or any other benzodiazepine.

Do not use this medication if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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