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amitriptyline and chlordiazepoxide (cont.)

What should I discuss with my healthcare provider before taking amitriptyline and chlordiazepoxide (Limbitrol, Limbitrol DS)?

You should not use this medication if you have recently had a heart attack, or if you are allergic to amitriptyline (Elavil), chlordiazepoxide (Librium), or to any benzodiazepine such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Do not use this medication if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days.

To make sure you can safely take amitriptyline and chlordiazepoxide, tell your doctor if you have any of these other conditions:

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

This medication can harm an unborn baby or cause birth defects. Do not use amitriptyline and chlordiazepoxide if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking amitriptyline and chlordiazepoxide.

The sedative effects of this medication may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking amitriptyline and chlordiazepoxide.

How should I take amitriptyline and chlordiazepoxide (Limbitrol, Limbitrol DS)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

If you need surgery, tell the surgeon ahead of time that you are using amitriptyline and chlordiazepoxide. You may need to stop using the medicine for a short time.

If you use this medication long-term, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Do not stop using amitriptyline and chlordiazepoxide suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using the medicine.

Amitriptyline and chlordiazepoxide may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Benzodiazepines are drugs of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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