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Medications and Drugs

Brand Names: Twynsta

Generic Name: amlodipine and telmisartan (Pronunciation: am LOE de peen and TEL me SAR tan)

What is amlodipine and telmisartan (Twynsta)?

Amlodipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.

Telmisartan is in a group of drugs called angiotensin II receptor antagonists. Telmisartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of amlodipine and telmisartan is used to treat high blood pressure (hypertension). It is sometimes used together with other blood pressure medications.

Amlodipine and telmisartan may also be used for purposes not listed in this medication guide.

What are the possible side effects of amlodipine and telmisartan (Twynsta)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, amlodipine and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.

Call your doctor at once if you have any other serious side effects, such as:

  • feeling like you might pass out;
  • swelling, rapid weight gain, feeling short of breath;
  • slow heart rate, weak pulse, muscle weakness, tingly feeling;
  • fast or pounding heartbeats;
  • urinating less than usual or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amlodipine and telmisartan (Twynsta)?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use potassium supplements or salt substitutes while you are taking amlodipine and telmisartan, unless your doctor has told you to.

Call your doctor at once if you have swelling in your hands or feet, rapid weight gain, feeling short of breath, fast or pounding heartbeats, urinating less than usual or not at all, jaundice (yellowing of the skin or eyes), slow heart rate, weak pulse, muscle weakness, tingly feeling, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling, or if you feel like you might pass out.

In rare cases, amlodipine and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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