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Medications and Drugs

Brand Names: AmBisome

Generic Name: amphotericin B liposomal (Pronunciation: AM foe TER i sin B LYE poe SOE mal)

What is amphotericin B liposomal (AmBisome)?

Amphotericin B liposomal is an antifungal antibiotic that fights infections caused by fungus.

Amphotericin B liposomal is used to treat serious, life-threatening fungal infections including leishmaniasis, and a certain form of meningitis in people infected with HIV (human immunodeficiency virus). Amphotericin B liposomal is not for treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina.

Amphotericin B liposomal may also be used for purposes not listed in this medication guide.

What are the possible side effects of amphotericin B liposomal (AmBisome)?

Some people receiving a amphotericin B liposomal injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, hot or cold, or if you have a fast heartbeat, chest tightness, or trouble breathing.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain, pounding heartbeats or fluttering in your chest;
  • feeling light-headed or short of breath;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, limp feeling);
  • loss of appetite, vomiting, urinating less than usual or not at all;
  • swelling, rapid weight gain;
  • pale skin, weakness, rapid heart rate, trouble concentrating; or
  • muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine).

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about amphotericin B liposomal (AmBisome)?

To make sure you can safely receive amphotericin B liposomal, tell your doctor if you have kidney or liver disease, or if you are allergic to amphotericin B (Abelcet, AmBisome, Amphotec, or Fungizone).

Amphotericin B liposomal may need to be given for up to several weeks or months, depending on the infection being treated.

Some people receiving a amphotericin B liposomal injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, hot or cold, or if you have a fast heartbeat, chest tightness, or trouble breathing.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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