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What should I discuss with my healthcare provider before receiving anti-thymocyte globulin (rabbit) (Thymoglobulin)?

You should not use this medication if you are allergic to rabbit proteins, or if you have ever had an allergic reaction to anti-thymocyte globulin.

To make sure you can safely take anti-thymocyte globulin, tell your doctor if you have any of these other conditions:

• an active or chronic infection; or
• a serious infection called sepsis.

FDA pregnancy category C. It is not known whether anti-thymocyte globulin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether anti-thymocyte globulin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using anti-thymocyte globulin.

Using anti-thymocyte globulin may increase your risk of developing certain types of cancer, such as lymphoma (cancer of the lymph nodes). Talk with your doctor about your specific risk.

How is anti-thymocyte globulin (rabbit) given (Thymoglobulin)?

Anti-thymocyte globulin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Anti-thymocyte globulin must be given slowly, and the IV infusion can take 4 to 6 hours to complete.

You may be given other medications to help prevent serious side effects or allergic reaction.

Anti-thymocyte globulin can lower blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

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