artemether and lumefantrine (cont.)
What happens if I miss a dose (Coartem)?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Coartem)?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an artemether and lumefantrine overdose are not known.
What should I avoid while taking artemether and lumefantrine (Coartem)?
Do not take halofantrine (Halfan) while you are taking artemether and lumefantrine or just after you stop taking it. Serious, life-threatening side effects on your heart can occur if you take these medications within 30 days of each other.
Avoid taking other anti-malaria medications while you are taking artemether and lumefantrine, unless your doctor has told you to.
Grapefruit and grapefruit juice may interact with artemether and lumefantrine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
What other drugs will affect artemether and lumefantrine (Coartem)?
Many drugs can interact with artemether and lumefantrine. Below is just a partial list. Tell your doctor if you are using:
- ketoconazole (Nizoral);
- cold or allergy medicines;
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
- an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), or desipramine (Norpramin);
- a heart rhythm medication such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), flecainide (Tambocor), procainamide (Procan, Pronestyl), propafenone (Rythmol), or quinidine (Quinaglute, Quinidex, Quin-Release);
- HIV or AIDS medicine such as delavirdine (Rescriptor) or ritonavir (Norvir);
- medicine to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran);
- medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
- migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or
- narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose).
This list is not complete and there may be other drugs that can interact with artemether and lumefantrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about artemether and lumefantrine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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