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Medications and Drugs

Brand Names: Synalgos-DC

Generic Name: aspirin, caffeine, and dihydrocodeine (Pronunciation: AS pir in, KAF een, and dye HYE dro KOE deen)

What is aspirin, caffeine, and dihydrocodeine (Synalgos-DC)?

Aspirin is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Dihydrocodeine is related to codeine. It is an opioid pain medication. An opioid is sometimes called a narcotic.

The combination of aspirin, caffeine, and dihydrocodeine is used to treat moderate to severe pain.

Aspirin, caffeine, and dihydrocodeine may also be used for purposes not listed in this medication guide.

What are the possible side effects of aspirin, caffeine, and dihydrocodeine (Synalgos-DC)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • shallow breathing, slow heart rate;
  • fast or pounding heart rate, muscle twitching;
  • confusion, unusual thoughts or behavior;
  • black, bloody, or tarry stools; or
  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • feeling dizzy, drowsy, shaky, anxious, or agitated;
  • nausea, vomiting, constipation;
  • itching or mild rash;
  • sleep problems (insomnia); or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about aspirin, caffeine, and dihydrocodeine (Synalgos-DC)?

You should not use this medication if you are allergic to aspirin, caffeine, or dihydrocodeine.

This medication should not be given to a child younger than 12 years old. Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Stop using this medication and call your doctor at once if you have any symptoms of bleeding in your stomach or intestines. Symptoms include black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.

Dihydrocodeine may be habit-forming and should be used only by the person this medicine was prescribed for. Keep the medication in a secure place where others cannot get to it.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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