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What should I discuss with my health care provider before receiving atropine and pralidoxime (DuoDote)?

If possible, before you receive atropine and pralidoxime, tell your doctor if you have:

• an allergy to any medication;
• heart disease, coronary artery disease;
• high blood pressure;
• kidney disease;
• asthma, COPD (chronic obstructive pulmonary disorder), bronchitis, emphysema, or other breathing problem;
• a heart rhythm disorder;
• narrow-angle glaucoma;
• an enlarged prostate or urination problems; or
• if you have recently had a heart attack.

FDA pregnancy category C. It is not known whether atropine and pralidoxime will harm an unborn baby. Tell your doctor if you are pregnant.

Atropine and pralidoxime can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation, it may not be possible before you are treated with atropine and pralidoxime to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is atropine and pralidoxime given (DuoDote)?

Atropine and pralidoxime is injected into a muscle in your upper thigh. A healthcare provider will give you this injection.

Atropine and pralidoxime is usually given as soon as possible after the onset of poisoning symptoms. If you still have symptoms after 10 to 15 minutes, you will receive 2 more injections.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving this medication.

After treatment with atropine and pralidoxime, you may be watched for up to 72 hours to make sure the medicine has been effective and you no longer have any effects of the poison.

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