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What happens if I miss a dose (DuoDote)?

Since atropine and pralidoxime is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.

What happens if I overdose (DuoDote)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Overdose may occur if you receive atropine and pralidoxime but you have not actually been exposed to the specific poisons this medication is designed to treat. Symptoms may include vision problems, feeling unsteady, loss of balance or coordination, trouble concentrating, fast heart rate, confusion, hallucinations (seeing or hearing things), decreased sweating, hot and dry skin, fainting, weak or shallow breathing, or breathing that stops.

What should I avoid after receiving atropine and pralidoxime (DuoDote)?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Atropine can decrease sweating and you may be more prone to heat stroke for a short time after receiving this medication.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect atropine and pralidoxime (DuoDote)?

If possible, before you receive this medication, tell your doctor about all other medicines you use, especially:

• aminophylline (Phyllocontin, Truphylline);
• morphine (Avinza, Kadian, MS Contin, Oramorph);
• reserpine;
• theophylline (Elixophyllin, Theo-24, Uniphyl);
• a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
• a tranquilizer such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine).

This list is not complete and other drugs may interact with atropine and pralidoxime. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about atropine and pralidoxime.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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