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What should I discuss with my health care provider before using belladonna and opium rectal (B & O Supprettes 15-A, B & O Supprettes 16-A)?

Do not use belladonna and opium if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) within the past 14 days.

Do not use belladonna and opium if you are also using linezolid (Zyvox), pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.

You should not use this medication if you are allergic to belladonna or opium, or if you have:

• glaucoma;
• urination problems or an enlarged prostate;
• severe liver or kidney disease;
• a blockage in your stomach or intestines;
• a history of head injury or brain tumor;
• epilepsy or other seizure disorder;
• diarrhea caused by infection;
• severe bleeding;
• a muscle disorder such as myasthenia gravis;
• asthma or severe breathing disorder;
• if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications; or
• if you are bed-ridden or otherwise debilitated.

To make sure you can safely use belladonna and opium, tell your doctor if you have any of these other conditions:

• liver or kidney disease;
• heart disease, high or low blood pressure;
• a stomach or intestinal disorder;
• chronic obstructive pulmonary disease (COPD) or other breathing problems;
• depression or mental illness;
• curvature of the spine;
• gallbladder disease;
• Addison's disease or other adrenal gland disorders;
• underactive thyroid;
• drug or alcohol addiction; or
• an allergy to atropine or any narcotic pain medicine such as hydrocodone (Lortab, Vicodin), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and others.

FDA pregnancy category C. It is not known whether belladonna and opium will harm an unborn baby. Opium may cause addiction or withdrawal symptoms in a newborn if the mother uses the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether belladonna and opium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Opium may be habit-forming and should be used only by the person it was prescribed for. Never share this medication with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

How should I use belladonna and opium rectal (B & O Supprettes 15-A, B & O Supprettes 16-A)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not take a belladonna and opium rectal suppository by mouth. It is for use only in your rectum.

Wash your hands before and after inserting the rectal suppository.

Try to empty your bowel and bladder just before using the belladonna and opium suppository.

Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

Lie on your back with your knees up toward your chest. Gently insert the suppository into your rectum about 1 inch.

For best results, stay lying down after inserting the suppository and hold it in your rectum for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom for at least an hour after using the suppository.

Drink plenty of water to prevent constipation while using belladonna and opium.

Belladonna and opium rectal is most often used 1 or 2 times per day. Do not use the suppositories more than 4 times per day. Follow your doctor's instructions. Call your doctor if your symptoms do not improve, or if they get worse while using this medication.

Do not stop using the medication suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using belladonna and opium rectal.

Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze the suppositories. Ask your pharmacist how to properly dispose of any unused suppositories that are no longer needed.

Keep track of the amount of medicine used from each new supply of this medication. Opium is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

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