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What should I discuss with my healthcare provider before receiving bortezomib (Velcade)?

You should not use this medication if you are allergic to bortezomib, mannitol, or boron.

To make sure you can safely receive bortezomib, tell your doctor if you have any of these other conditions:

• diabetes;
• liver disease;
• kidney disease, or if you are on dialysis;
• a bleeding or blood clotting disorder;
• a low level of platelets or white or red blood cells;
• heart disease, congestive heart failure;
• herpes or a history of shingles;
• high or low blood pressure; or
• nerve problems such as numbness, burning, pain, or tingly feeling.

FDA pregnancy category D. Do not use bortezomib if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether bortezomib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using bortezomib.

How is bortezomib given (Velcade)?

Bortezomib is injected into a vein through an IV.

You will receive this injection in a clinic or hospital setting. A doctor, nurse, or other healthcare provider will give you this injection.

Bortezomib is usually injected 2 times a week for 2 weeks, followed by 10 days without an injection. Bortezomib may also be given once a week for 4 weeks followed by 13 days without an injection. Follow your doctor's instructions about your individual dosing schedule.

Bortezomib can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

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